Harris D Bernstein

Genetics and Biochemistry Branch of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health

Affiliated withNational Institutes of Health

Research Area

Immunology and Infection

Biography

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2013

Other Publications

Article	Year
Protein targeting: getting into the groove. Current biology : CB\| PubMed ID: 9778518	1998
Membrane protein biogenesis: the exception explains the rules. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9843931	1998
The structure of multiple polypeptide domains determines the signal recognition particle targeting requirement of Escherichia coli inner membrane proteins. Journal of bacteriology\| PubMed ID: 10419954	1999
The biogenesis and assembly of bacterial membrane proteins. Current opinion in microbiology\| PubMed ID: 10744997	2000
Physiological basis for conservation of the signal recognition particle targeting pathway in Escherichia coli. Journal of bacteriology\| PubMed ID: 11244056	2001
The targeting pathway of Escherichia coli presecretory and integral membrane proteins is specified by the hydrophobicity of the targeting signal. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11248102	2001
Evidence for a novel GTPase priming step in the SRP protein targeting pathway. The EMBO journal\| PubMed ID: 11726508	2001
Trigger factor retards protein export in Escherichia coli. The Journal of biological chemistry\| PubMed ID: 12205085	2002
DnaK promotes the selective export of outer membrane protein precursors in SecA-deficient Escherichia coli. The Journal of biological chemistry\| PubMed ID: 12403776	2002
Signal recognition particle (SRP)-mediated targeting and Sec-dependent translocation of an extracellular Escherichia coli protein. The Journal of biological chemistry\| PubMed ID: 12466262	2003
Basic amino acids in a distinct subset of signal peptides promote interaction with the signal recognition particle. The Journal of biological chemistry\| PubMed ID: 12949068	2003
Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain. Nucleic acids research\| PubMed ID: 15383645	2004
An unusual signal peptide facilitates late steps in the biogenesis of a bacterial autotransporter. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15615856	2005
Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter. Molecular microbiology\| PubMed ID: 16262782	2005
An unusual signal peptide extension inhibits the binding of bacterial presecretory proteins to the signal recognition particle, trigger factor, and the SecYEG complex. The Journal of biological chemistry\| PubMed ID: 16455668	2006
Translation arrest requires two-way communication between a nascent polypeptide and the ribosome. Molecular cell\| PubMed ID: 16762832	2006
The surprising complexity of signal sequences. Trends in biochemical sciences\| PubMed ID: 16919958	2006
Characterization of a novel two-partner secretion system in Escherichia coli O157:H7. Journal of bacteriology\| PubMed ID: 17322314	2007
Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism. The EMBO journal\| PubMed ID: 17347646	2007
Protein secretion in gram-negative bacteria via the autotransporter pathway. Annual review of microbiology\| PubMed ID: 17506669	2007
Are bacterial 'autotransporters' really transporters? Trends in microbiology\| PubMed ID: 17935998	2007
Autotransporter structure reveals intra-barrel cleavage followed by conformational changes. Nature structural & molecular biology\| PubMed ID: 17994105	2007
Incorporation of a polypeptide segment into the beta-domain pore during the assembly of a bacterial autotransporter. Molecular microbiology\| PubMed ID: 18047580	2008
Identification of a post-targeting step required for efficient cotranslational translocation of proteins across the Escherichia coli inner membrane. The Journal of biological chemistry\| PubMed ID: 19211555	2009
The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel. Molecular cell\| PubMed ID: 19394297	2009
Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19850876	2009
Sequential translocation of an Escherchia coli two-partner secretion pathway exoprotein across the inner and outer membranes. Molecular microbiology\| PubMed ID: 19968793	2010
Molecular basis for the structural stability of an enclosed β-barrel loop. Journal of molecular biology\| PubMed ID: 20655928	2010
The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding. Molecular microbiology\| PubMed ID: 20804452	2010
Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20876094	2010
The double life of a bacterial lipoprotein. Molecular microbiology\| PubMed ID: 21338414	2011
The translational regulatory function of SecM requires the precise timing of membrane targeting. Molecular microbiology\| PubMed ID: 21635582	2011
Residues in a conserved α-helical segment are required for cleavage but not secretion of an Escherichia coli serine protease autotransporter passenger domain. Journal of bacteriology\| PubMed ID: 21642456	2011
Sequential and spatially restricted interactions of assembly factors with an autotransporter beta domain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21646511	2011
Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporter. Journal of molecular biology\| PubMed ID: 22094314	2012
Cell biology: All clear for ribosome landing. Nature\| PubMed ID: 23235870	2012
Mechanistic link between β barrel assembly and the initiation of autotransporter secretion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23431155	2013
Mutations in the Escherichia coli ribosomal protein L22 selectively suppress the expression of a secreted bacterial virulence factor. Journal of bacteriology\| PubMed ID: 23625843	2013
Charge-dependent secretion of an intrinsically disordered protein via the autotransporter pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24145447	2013
Stepwise folding of an autotransporter passenger domain is not essential for its secretion. The Journal of biological chemistry\| PubMed ID: 24165126	2013
Reconstitution of bacterial autotransporter assembly using purified components. eLife\| PubMed ID: 25182416	2014
Of linkers and autochaperones: an unambiguous nomenclature to identify common and uncommon themes for autotransporter secretion. Molecular microbiology\| PubMed ID: 25345653	2015
Analysis of the outer membrane proteome and secretome of Bacteroides fragilis reveals a multiplicity of secretion mechanisms. PloS one\| PubMed ID: 25658944	2015
Looks can be deceiving: recent insights into the mechanism of protein secretion by the autotransporter pathway. Molecular microbiology\| PubMed ID: 25881492	2015
An In Vitro Assay for Outer Membrane Protein Assembly by the BAM Complex. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26427687	2015
Type V Secretion: the Autotransporter and Two-Partner Secretion Pathways. EcoSal Plus\| PubMed ID: 26443787	2010
Surface-Exposed Lipoproteins: An Emerging Secretion Phenomenon in Gram-Negative Bacteria. Trends in microbiology\| PubMed ID: 26711681	2016
Enterohemorrhagic reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 26855967	2016
Genomic Diversity of Enterotoxigenic Strains of Bacteroides fragilis. PloS one\| PubMed ID: 27348220	2016
Selective pressure for rapid membrane integration constrains the sequence of bacterial outer membrane proteins. Molecular microbiology\| PubMed ID: 28941249	2017
Folding of a bacterial integral outer membrane protein is initiated in the periplasm. Nature communications\| PubMed ID: 29101319	2017
The Bam complex catalyzes efficient insertion of bacterial outer membrane proteins into membrane vesicles of variable lipid composition. The Journal of biological chemistry\| PubMed ID: 29311257	2018
Identification of a novel post-insertion step in the assembly of a bacterial outer membrane protein. Molecular microbiology\| PubMed ID: 30107065	2018