Alexander J. Szalai

Department of Medicine, University of Alabama at Birmingham

Affiliated withUniversity of Alabama at Birmingham

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2014

Other Publications

Article	Year
The antimicrobial activity of C-reactive protein. Microbes and infection / Institut Pasteur\| PubMed ID: 11880053	2002
Experimental allergic encephalomyelitis is inhibited in transgenic mice expressing human C-reactive protein. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12023381	2002
Varied biologic functions of C-reactive protein: lessons learned from transgenic mice. Immunologic research\| PubMed ID: 12403365	2002
Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae. Infection and immunity\| PubMed ID: 12496151	2003
The biological functions of C-reactive protein. Vascular pharmacology\| PubMed ID: 12616974	2002
Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene. Arthritis and rheumatism\| PubMed ID: 12794828	2003
Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeutics. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12847219	2003
Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice. Circulation\| PubMed ID: 12874178	2003
Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface. Infection and immunity\| PubMed ID: 14688088	2004
C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation\| PubMed ID: 14744975	2004
Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro. Blood\| PubMed ID: 14976045	2004
Fc receptors and the common gamma-chain in experimental autoimmune encephalomyelitis. Journal of neuroscience research\| PubMed ID: 14991835	2004
Murine complement C4 is not required for experimental autoimmune encephalomyelitis. Glia\| PubMed ID: 15390104	2005
Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15514207	2005
C-reactive protein (CRP) and autoimmune disease: facts and conjectures. Clinical & developmental immunology\| PubMed ID: 15559367	2004
The virulence function of Streptococcus pneumoniae surface protein A involves inhibition of complement activation and impairment of complement receptor-mediated protection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15585877	2004
Estrogen treatment abrogates neointima formation in human C-reactive protein transgenic mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16051879	2005
C3a expressed in the central nervous system protects against LPS-induced shock. Neuroscience letters\| PubMed ID: 16085360	2005
Complement as a biomarker in multiple sclerosis. Journal of neuropathology and experimental neurology\| PubMed ID: 16106223	2005
Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis. Experimental eye research\| PubMed ID: 16143328	2006
Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis. European journal of immunology\| PubMed ID: 16278814	2005
Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated. Molecular immunology\| PubMed ID: 16310250	2006
Complement and demyelinating disease: no MAC needed? Brain research reviews\| PubMed ID: 16443278	2006
Experimental autoimmune uveitis in the C57BL/6 mouse. Experimental eye research\| PubMed ID: 16524572	2006
Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nature medicine\| PubMed ID: 16582918	2006
Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease. Molecular immunology\| PubMed ID: 17353050	2007
C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk. Journal of the American College of Cardiology\| PubMed ID: 17868801	2007
PspA and PspC minimize immune adherence and transfer of pneumococci from erythrocytes to macrophages through their effects on complement activation. Infection and immunity\| PubMed ID: 17923519	2007
Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent. The American journal of pathology\| PubMed ID: 18063701	2008
Neointimal formation is reduced after arterial injury in human crp transgenic mice. Atherosclerosis\| PubMed ID: 18358478	2008
Impaired endothelial function in C-reactive protein overexpressing mice. Atherosclerosis\| PubMed ID: 18433756	2008
Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18606652	2008
Antibody to the type 3 capsule facilitates immune adherence of pneumococci to erythrocytes and augments their transfer to macrophages. Infection and immunity\| PubMed ID: 19001076	2009
The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk. Current atherosclerosis reports\| PubMed ID: 19228486	2009
C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease. Hypertension\| PubMed ID: 20157054	2010
C-reactive protein-mediated vascular injury requires complement. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20339115	2010
Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence. Infection and immunity\| PubMed ID: 20439480	2010
Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is FcγRIIB Dependent. Autoimmune diseases\| PubMed ID: 21151582	2011
C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 21383672	2011
Collagen-induced arthritis is exacerbated in C-reactive protein-deficient mice. Arthritis and rheumatism\| PubMed ID: 21567377	2011
An about-face for C-reactive protein? Clinical chemistry\| PubMed ID: 21821724	2011
Biomarkers of inflammation and hemostasis associated with left ventricular mass: The Multiethnic Study of Atherosclerosis (MESA). International journal of molecular epidemiology and genetics\| PubMed ID: 22200000	2011
Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement. Journal of the American Society of Nephrology : JASN\| PubMed ID: 22518005	2012
Associations of C-Reactive Protein to Indices of Vascular Health and the Influence of Serum 25(OH)D Status in Healthy Adults. Journal of nutrition and metabolism\| PubMed ID: 23029606	2012
Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface phosphocholine. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23105137	2012
C-reactive protein exacerbates renal ischemia-reperfusion injury. American journal of physiology. Renal physiology\| PubMed ID: 23535585	2013
A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans. Molecular therapy. Nucleic acids\| PubMed ID: 23629027	2012
Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils. Arthritis and rheumatism\| PubMed ID: 23918739	2013
C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration. Clinical science (London, England : 1979)\| PubMed ID: 24206243	2014
Inhibiting C-reactive protein for the treatment of cardiovascular disease: promising evidence from rodent models. Mediators of inflammation\| PubMed ID: 24803739	2014
Associations between Abnormal Rod-Mediated Dark Adaptation and Health and Functioning in Older Adults with Normal Macular Health. Investigative ophthalmology & visual science\| PubMed ID: 24854857	2014
Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24876352	2014