Chris B. Schaffer

Department of Biomedical Engineering, Cornell University

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2014

Other Publications

Article	Year
All-optical histology using ultrashort laser pulses. Neuron\| PubMed ID: 12848930	2003
Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLoS biology\| PubMed ID: 16379497	2006
Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nature methods\| PubMed ID: 16432519	2006
Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor. Mechanics & chemistry of biosystems : MCB\| PubMed ID: 16708469	2005
Spectroscopic analysis of the oxygenation state of hemoglobin using coherent anti-Stokes Raman scattering. Journal of biomedical optics\| PubMed ID: 17092146	2006
Penetrating arterioles are a bottleneck in the perfusion of neocortex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17190804	2007
Large two-photon absorptivity of hemoglobin in the infrared range of 780-880 nm. The Journal of chemical physics\| PubMed ID: 17228976	2007
Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection-enhanced neural drug delivery. Biomedical microdevices\| PubMed ID: 19353271	2009
Photonic band-gap fiber gas cell fabricated using femtosecond micromachining. Optics express\| PubMed ID: 19546979	2007
Deep tissue multiphoton microscopy using longer wavelength excitation. Optics express\| PubMed ID: 19654740	2009
Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20709864	2010
Limitations of collateral flow after occlusion of a single cortical penetrating arteriole. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20842163	2010
Optical tools to produce and study small strokes in animal models. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 21097239	2010
In vivo imaging of myelin in the vertebrate central nervous system using third harmonic generation microscopy. Biophysical journal\| PubMed ID: 21354410	2011
Optically quantified cerebral blood flow. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21364601	2011
Sub-surface, micrometer-scale incisions produced in rodent cortex using tightly-focused femtosecond laser pulses. Lasers in surgery and medicine\| PubMed ID: 21674543	2011
Occlusion of cortical ascending venules causes blood flow decreases, reversals in flow direction, and vessel dilation in upstream capillaries. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21712834	2011
Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage. Circulation\| PubMed ID: 21911784	2011
Preictal and ictal neurovascular and metabolic coupling surrounding a seizure focus. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21917812	2011
Real-time imaging of perivascular transport of nanoparticles during convection-enhanced delivery in the rat cortex. Annals of biomedical engineering\| PubMed ID: 22009318	2012
Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration. PloS one\| PubMed ID: 22028924	2011
Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration. Science translational medicine\| PubMed ID: 22158860	2011
Estimating brain microvascular blood flows from partial two-photon microscopy data by computation with a circuit model. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 22254278	2011
Notch4 normalization reduces blood vessel size in arteriovenous malformations. Science translational medicine\| PubMed ID: 22261032	2012
Chronic in vivo imaging in the mouse spinal cord using an implanted chamber. Nature methods\| PubMed ID: 22266542	2012
In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile blood flow in cortical blood vessels in mice. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22268102	2012
Cyclic strain anisotropy regulates valvular interstitial cell phenotype and tissue remodeling in three-dimensional culture. Acta biomaterialia\| PubMed ID: 22281945	2012
Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 22293983	2012
Line-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animals. PloS one\| PubMed ID: 22761686	2012
Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PloS one\| PubMed ID: 23408937	2013
Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies. The Lancet. Neurology\| PubMed ID: 23518332	2013
Big effects from tiny vessels: imaging the impact of microvascular clots and hemorrhages on the brain. Stroke; a journal of cerebral circulation\| PubMed ID: 23709743	2013
Stimulus-evoked calcium transients in somatosensory cortex are temporarily inhibited by a nearby microhemorrhage. PloS one\| PubMed ID: 23724147	2013
Optoporation and genetic manipulation of cells using femtosecond laser pulses. Biophysical journal\| PubMed ID: 23972838	2013
The challenge of connecting the dots in the B.R.a.I.N. Neuron\| PubMed ID: 24139032	2013
Optically induced occlusion of single blood vessels in rodent neocortex. Cold Spring Harbor protocols\| PubMed ID: 24298038	2013
In vivo three-photon microscopy of subcortical structures within an intact mouse brain. Nature photonics\| PubMed ID: 24353743	2013
TRAIL-coated leukocytes that kill cancer cells in the circulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24395803	2014
Growth and hemodynamics after early embryonic aortic arch occlusion. Biomechanics and modeling in mechanobiology\| PubMed ID: 25416845	2014