Charles F. Mactutus

Laboratory Program in Behavioral, University of South Carolina

Affiliated withUniversity of South Carolina

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 6	Year
Publication title	2016
Publication title	2018
Publication title	2021
Publication title	2020
Publication title	2020

Other Publications

Article	Year
Cell culture models of oxidative stress and injury in the central nervous system. Current neurovascular research\| PubMed ID: 16181101	2005
Long-term retention of spatial navigation by preweanling rats. Developmental psychobiology\| PubMed ID: 11835152	2002
Enduring effects of prenatal cocaine exposure on attention and reaction to errors. Behavioral neuroscience\| PubMed ID: 12148929	2002
Proximal versus distal cue utilization in spatial navigation: the role of visual acuity? Neurobiology of learning and memory\| PubMed ID: 12431421	2002
Proximal versus distal cue utilization in preweanling spatial localization: the influence of cue number and location. Physiology & behavior\| PubMed ID: 12834786	2003
Temporal relationships between HIV-1 Tat-induced neuronal degeneration, OX-42 immunoreactivity, reactive astrocytosis, and protein oxidation in the rat striatum. Brain research\| PubMed ID: 14499939	2003
Impaired sustained attention and altered reactivity to errors in an animal model of prenatal cocaine exposure. Brain research. Developmental brain research\| PubMed ID: 14741754	2003
Prenatal cocaine exposure does not alter working memory in adult rats. Neurotoxicology and teratology\| PubMed ID: 15019965	2004
Enduring effects of prenatal cocaine exposure on selective attention and reactivity to errors: evidence from an animal model. Behavioral neuroscience\| PubMed ID: 15113253	2004
Sex differences and repeated intravenous nicotine: behavioral sensitization and dopamine receptors. Pharmacology, biochemistry, and behavior\| PubMed ID: 15251267	2004
Prenatal intravenous cocaine and the heart rate-orienting response: a dose-response study. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 15380828	2004
Cocaine-induced inhibition of process outgrowth in locus coeruleus neurons: role of gestational exposure period and offspring sex. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 15380829	2004
Gonadal steroids differentially modulate neurotoxicity of HIV and cocaine: testosterone and ICI 182,780 sensitive mechanism. BMC neuroscience\| PubMed ID: 15943860	2005
Acute and repeated intravenous cocaine-induced locomotor activity is altered as a function of sex and gonadectomy. Pharmacology, biochemistry, and behavior\| PubMed ID: 16139878	2005
Home cage observations following acute and repeated IV cocaine in intact and gonadectomized rats. Neurotoxicology and teratology\| PubMed ID: 16214304	2005
HIV-1 Tat neurotoxicity in primary cultures of rat midbrain fetal neurons: changes in dopamine transporter binding and immunoreactivity. Neuroscience letters\| PubMed ID: 16356633	2006
Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: the role of oxidative stress and D1 dopamine receptor. Neurotoxicology\| PubMed ID: 16386305	2006
Neonatal hippocampal Tat injections: developmental effects on prepulse inhibition (PPI) of the auditory startle response. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 16530999	2006
Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats. BMC neuroscience\| PubMed ID: 16620392	2006
Neonatal intrahippocampal glycoprotein 120 injection: the role of dopaminergic alterations in prepulse inhibition in adult rats. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16785316	2006
Intrahippocampal injections of Tat: effects on prepulse inhibition of the auditory startle response in adult male rats. Pharmacology, biochemistry, and behavior\| PubMed ID: 16790267	2006
Dopaminergic marker proteins in the substantia nigra of human immunodeficiency virus type 1-infected brains. Journal of neurovirology\| PubMed ID: 16798675	2006
Microanatomy in 21 day rat brains exposed prenatally to cocaine. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 16814973	2006
Neonatal intrahippocampal gp120 injection: an examination early in development. Neurotoxicology\| PubMed ID: 16973215	2007
Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling. Neuroscience\| PubMed ID: 17084983	2007
Sex differences in nicotine levels following repeated intravenous injection in rats are attenuated by gonadectomy. Pharmacology, biochemistry, and behavior\| PubMed ID: 17270256	2007
Automation of the novel object recognition task for use in adolescent rats. Journal of neuroscience methods\| PubMed ID: 17719091	2007
Neurotoxicity of HIV-1 Tat protein: involvement of D1 dopamine receptor. Neurotoxicology\| PubMed ID: 17764744	2007
Differential long-term neurotoxicity of HIV-1 proteins in the rat hippocampal formation: a design-based stereological study. Hippocampus\| PubMed ID: 17924522	2008
Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 17933484	2007
Effects of chronic adult dietary restriction on spatial learning in the aged F344 x BN hybrid F1 rat. Physiology & behavior\| PubMed ID: 18035382	2008
Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: current status of dopamine system vulnerability in NeuroAIDS. Neuroscience and biobehavioral reviews\| PubMed ID: 18430470	2008
Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons. Neurotoxicology\| PubMed ID: 18606182	2008
Neonatal intrahippocampal injection of the HIV-1 proteins gp120 and Tat: differential effects on behavior and the relationship to stereological hippocampal measures. Brain research\| PubMed ID: 18674522	2008
Neuronal survival and resistance to HIV-1 Tat toxicity in the primary culture of rat fetal neurons. Experimental neurology\| PubMed ID: 19013459	2009
In vivo microdialysis in awake, freely moving rats demonstrates HIV-1 Tat-induced alterations in dopamine transmission. Synapse (New York, N.Y.)\| PubMed ID: 19086089	2009
The ART of HIV therapies: dopaminergic deficits and future treatments for HIV pediatric encephalopathy. Expert review of anti-infective therapy\| PubMed ID: 19254168	2009
HIV-1 Tat protein-induced rapid and reversible decrease in [3H]dopamine uptake: dissociation of [3H]dopamine uptake and [3H]2beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (WIN 35,428) bin... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 19325033	2009
The human immunodeficiency virus-1-associated protein, Tat1-86, impairs dopamine transporters and interacts with cocaine to reduce nerve terminal function: a no-net-flux microdialysis study. Neuroscience\| PubMed ID: 19344635	2009
Dose-dependent long-term effects of Tat in the rat hippocampal formation: a design-based stereological study. Hippocampus\| PubMed ID: 19489004	2010
Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures. Experimental neurology\| PubMed ID: 19615365	2009
Evidence for developmental dopaminergic alterations in the human immunodeficiency virus-1 transgenic rat. Journal of neurovirology\| PubMed ID: 20337512	2010
ER-β mediates 17β-estradiol attenuation of HIV-1 Tat-induced apoptotic signaling. Synapse (New York, N.Y.)\| PubMed ID: 20340172	2010
Hyperdopaminergic tone in HIV-1 protein treated rats and cocaine sensitization. Journal of neurochemistry\| PubMed ID: 20796175	2010
Prenatal IV nicotine exposure produces a sex difference in sensorimotor gating of the auditory startle reflex in adult rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 21145386	2011
Effect of environmental enrichment on methylphenidate-induced locomotion and dopamine transporter dynamics. Behavioural brain research\| PubMed ID: 21219939	2011
Recombinant human immunodeficiency virus-1 transactivator of transcription1-86 allosterically modulates dopamine transporter activity. Synapse (New York, N.Y.)\| PubMed ID: 21538554	2011
Endogenous amyloidogenesis in long-term rat hippocampal cell cultures. BMC neuroscience\| PubMed ID: 21569253	2011
Prenatal IV Cocaine: Alterations in Auditory Information Processing. Frontiers in psychiatry\| PubMed ID: 21747770	2011
Prenatal cocaine exposure alters progenitor cell markers in the subventricular zone of the adult rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 22119286	2012
Adolescent HIV-1 transgenic rats: evidence for dopaminergic alterations in behavior and neurochemistry revealed by methamphetamine challenge. Current HIV research\| PubMed ID: 22591365	2012
Soy isoflavones genistein and daidzein exert anti-apoptotic actions via a selective ER-mediated mechanism in neurons following HIV-1 Tat(1-86) exposure. PloS one\| PubMed ID: 22629415	2012
Environmental enrichment alters nicotine-mediated locomotor sensitization and phosphorylation of DARPP-32 and CREB in rat prefrontal cortex. PloS one\| PubMed ID: 22952905	2012
Time and time again: temporal processing demands implicate perceptual and gating deficits in the HIV-1 transgenic rat. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 23690140	2013
HIV-1 Tat protein variants: critical role for the cysteine region in synaptodendritic injury. Experimental neurology\| PubMed ID: 23811015	2013
Synaptodendritic recovery following HIV Tat exposure: neurorestoration by phytoestrogens. Journal of neurochemistry\| PubMed ID: 23875777	2014
Modeling deficits in attention, inhibition, and flexibility in HAND. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 24764039	2014
HIV-1 transgenic female rat: synaptodendritic alterations of medium spiny neurons in the nucleus accumbens. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 25037595	2014
Neonatal intrahippocampal HIV-1 protein Tat(1-86) injection: neurobehavioral alterations in the absence of increased inflammatory cytokine activation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 25285887	2014
Polytocus focus: Uterine position effect is dependent upon horn size. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 25447787	2015
HIV-1 proteins, Tat and gp120, target the developing dopamine system. Current HIV research\| PubMed ID: 25613135	2015
The role of sensory modality in prepulse inhibition: An ontogenetic study. Developmental psychobiology\| PubMed ID: 26415825	2015
HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol. Frontiers in microbiology\| PubMed ID: 26441850	2015
Intravenous Prenatal Nicotine Exposure Alters METH-Induced Hyperactivity, Conditioned Hyperactivity, and BDNF in Adult Rat Offspring. Developmental neuroscience\| PubMed ID: 27287203	2016
Selective developmental alterations in The HIV-1 transgenic rat: Opportunities for diagnosis of pediatric HIV-1. Journal of neurovirology\| PubMed ID: 27538996	2017
A Gap in Time: Extending our Knowledge of Temporal Processing Deficits in the HIV-1 Transgenic Rat. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 27699630	2017
Temporal processsing demands in the HIV-1 transgenic rat: Amodal gating and implications for diagnostics. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 28040491	2017
Evolution of the HIV-1 transgenic rat: utility in assessing the progression of HIV-1-associated neurocognitive disorders. Journal of neurovirology\| PubMed ID: 28730408	2017
Dose-dependent neurocognitive deficits following postnatal day 10 HIV-1 viral protein exposure: Relationship to hippocampal anatomy parameters. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 29111178	2018
Sex Matters: Robust Sex Differences in Signal Detection in the HIV-1 Transgenic Rat. Frontiers in behavioral neuroscience\| PubMed ID: 29163084	2017
HIV-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum. PloS one\| PubMed ID: 29176843	2017
Unraveling Individual Differences In The HIV-1 Transgenic Rat: Therapeutic Efficacy Of Methylphenidate. Scientific reports\| PubMed ID: 29317696	2018
HIV-1 proteins dysregulate motivational processes and dopamine circuitry. Scientific reports\| PubMed ID: 29777165	2018
Synaptic Connectivity in Medium Spiny Neurons of the Nucleus Accumbens: A Sex-Dependent Mechanism Underlying Apathy in the HIV-1 Transgenic Rat. Frontiers in behavioral neuroscience\| PubMed ID: 30524255	2018
Diagnostic and prognostic biomarkers for HAND. Journal of neurovirology\| PubMed ID: 30607890	2019
Disruption of Timing: NeuroHIV Progression in the Post-cART Era. Scientific reports\| PubMed ID: 30696863	2019
Posterior ventral tegmental area-nucleus accumbens shell circuitry modulates response to novelty. PloS one\| PubMed ID: 30835756	2019
Selective monoaminergic and histaminergic circuit dysregulation following long-term HIV-1 protein exposure. Journal of neurovirology\| PubMed ID: 31102184	2019
Neurorestoration of Sustained Attention in a Model of HIV-1 Associated Neurocognitive Disorders. Frontiers in behavioral neuroscience\| PubMed ID: 31447657	2019
An Empirical Mediation Analysis of Mechanisms Underlying HIV-1-Associated Neurocognitive Disorders. Brain research\| PubMed ID: 31513791	2019
Selective Estrogen Receptor β Agonists: a Therapeutic Approach for HIV-1 Associated Neurocognitive Disorders. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 31858373	2019
HIV Infection and Neurocognitive Disorders in the Context of Chronic Drug Abuse: Evidence for Divergent Findings Dependent upon Prior Drug History. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 32533296	2020
Correction to: HIV Infection and Neurocognitive Disorders in the Context of Chronic Drug Abuse: Evidence for Divergent Findings Dependent upon Prior Drug History. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 32725581	2020
S-EQUOL: a neuroprotective therapeutic for chronic neurocognitive impairments in pediatric HIV. Journal of neurovirology\| PubMed ID: 32870477	2020
Progression of temporal processing deficits in the HIV-1 transgenic rat. Scientific reports\| PubMed ID: 27596023	2016
Chronic SSRI treatment reverses HIV-1 protein-mediated synaptodendritic damage. Journal of neurovirology\| PubMed ID: 34003469	2021
Microglial HIV-1 Expression: Role in HIV-1 Associated Neurocognitive Disorders. Viruses\| PubMed ID: 34067600	2021
S-Equol mitigates motivational deficits and dysregulation associated with HIV-1. Scientific reports\| PubMed ID: 34088932	2021
HIV-Associated Apathy/Depression and Neurocognitive Impairments Reflect Persistent Dopamine Deficits. Cells\| PubMed ID: 34440928	2021
Neurodevelopmental Processes in the Prefrontal Cortex Derailed by Chronic HIV-1 Viral Protein Exposure. Cells\| PubMed ID: 34831259	2021
Intraneuronal β-Amyloid Accumulation: Aging HIV-1 Human and HIV-1 Transgenic Rat Brain. Viruses\| PubMed ID: 35746739	2022
Synaptic dysfunction is associated with alterations in the initiation of goal-directed behaviors: Implications for HIV-1-associated apathy. Experimental neurology\| PubMed ID: 35863502	2022
Disrupted Decision-Making: EcoHIV Inoculation in Cocaine Dependent Rats. International journal of molecular sciences\| PubMed ID: 36012364	2022
Microglia proliferation underlies synaptic dysfunction in the prefrontal cortex: implications for the pathogenesis of HIV-1-associated neurocognitive and affective alterations. Journal of neurovirology\| PubMed ID: 37222970	2023
Therapeutically targeting the consequences of HIV-1-associated gastrointestinal dysbiosis: Implications for neurocognitive and affective alterations. Pharmacology, biochemistry, and behavior\| PubMed ID: 37390973	2023
HIV-1 mRNA Knockdown with CRISPR/Cas9 Enhances Neurocognitive Function. Research square\| PubMed ID: 37886577	2023
SARS-CoV-2 RNA persists in the central nervous system of non-human primates despite clinical recovery. Molecular biomedicine\| PubMed ID: 37934362	2023
HIV-1 mRNA knockdown with CRISPR/CAS9 enhances neurocognitive function. Journal of neurovirology\| PubMed ID: 38355914	2024
Adolescent oral oxycodone self-administration disrupts neurobehavioral and neurocognitive development. Neuropharmacology\| PubMed ID: 38981578	2024