Gerd Geisslinger

Institute of Clinical Pharmacology, Goethe University Hospital Frankfurt

Affiliated withGoethe University Hospital Frankfurt

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2016

Other Publications

Article	Year
Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling. Journal of Crohn's & colitis\| PubMed ID: 26928964	2016
Loss of HIF-1α in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model. Oncotarget\| PubMed ID: 27015123	2016
Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action. Clinical pharmacology and therapeutics\| PubMed ID: 16413243	2006
Current evidence for a genetic modulation of the response to analgesics. Pain\| PubMed ID: 16472919	2006
Rapid identification of three functionally relevant polymorphisms in the OATP1B1 transporter gene using Pyrosequencing. Pharmacogenomics\| PubMed ID: 16515396	2006
Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences? Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 16586083	2006
Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib. Biochemical and biophysical research communications\| PubMed ID: 16598848	2006
High sensitive determination of sufentanil in human plasma of parturients and neonates following patient-controlled epidural analgesia (PCEA). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 16621739	2006
Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. Blood\| PubMed ID: 16690965	2006
Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment. European journal of pharmacology\| PubMed ID: 16730702	2006
Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors. Journal of the National Cancer Institute\| PubMed ID: 16757698	2006
The glutamate transporter GLAST is involved in spinal nociceptive processing. Biochemical and biophysical research communications\| PubMed ID: 16765320	2006
Misestimating the role of an active metabolite when modeling the effects after administration of the parent compound only. Clinical pharmacology and therapeutics\| PubMed ID: 16815321	2006
Is mPGES-1 a promising target for pain therapy? Trends in pharmacological sciences\| PubMed ID: 16815559	2006
Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16816110	2006
Nimodipine plasma concentration and retinal blood flow in healthy subjects. Investigative ophthalmology & visual science\| PubMed ID: 16877419	2006
The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers. Pharmacogenetics and genomics\| PubMed ID: 16906017	2006
Fatal respiratory depression after multiple intravenous morphine injections. Clinical pharmacokinetics\| PubMed ID: 17048971	2006
Pyrosequencing-based screening for genetic polymorphisms in cytochrome P450 2B6 of potential clinical relevance. Pharmacogenomics\| PubMed ID: 17054410	2006
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nature medicine\| PubMed ID: 17057711	2006
LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples. Prostaglandins & other lipid mediators\| PubMed ID: 17085324	2006
The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production. Clinical pharmacology and therapeutics\| PubMed ID: 17178263	2006
Pharmacological and histopathological characterization of a hyperalgesia model induced by freeze lesion. Pain\| PubMed ID: 17189672	2007
Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB. European journal of pharmacology\| PubMed ID: 17217946	2007
FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17277153	2007
The effects of COX-2 selective and non-selective NSAIDs on the initiation and progression of atherosclerosis in ApoE-/- mice. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 17318614	2007
Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms. Clinical chemistry\| PubMed ID: 17363416	2007
PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors. Biochemical pharmacology\| PubMed ID: 17452035	2007
FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions. Molecular immunology\| PubMed ID: 17475330	2007
Association of saquinavir plasma concentrations with side effects but not with antiretroviral outcome in patients infected with protease inhibitor-susceptible human immunodeficiency virus ty... Antimicrobial agents and chemotherapy\| PubMed ID: 17576836	2007
Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study. Clinical therapeutics\| PubMed ID: 17577465	2007
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. Molecular biology of the cell\| PubMed ID: 17652460	2007
The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception. Biochemical and biophysical research communications\| PubMed ID: 17692820	2007
Current evidence for a modulation of nociception by human genetic polymorphisms. Pain\| PubMed ID: 17706868	2007
Rapid screening for potentially relevant polymorphisms in the human fatty acid amide hydrolase gene using Pyrosequencing. Prostaglandins & other lipid mediators\| PubMed ID: 17991615	2007
p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells. Biochemical and biophysical research communications\| PubMed ID: 18036557	2008
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast cancer research and treatment\| PubMed ID: 18058224	2008
Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. Pharmacogenomics\| PubMed ID: 18085997	2007
Proteomics in neuropathic pain research. Anesthesiology\| PubMed ID: 18212577	2008
Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18256252	2008
Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction. Circulation\| PubMed ID: 18347209	2008
Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype. European journal of pain (London, England)\| PubMed ID: 18374612	2008
Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses. The Journal of biological chemistry\| PubMed ID: 18390541	2008
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice. Journal of cellular and molecular medicine\| PubMed ID: 18419601	2008
Genetic polymorphism of the type A human natriuretic peptide receptor (NPR-A) gene contributes to the interindividual variability in the BNP system. European journal of heart failure\| PubMed ID: 18436476	2008
Antinociceptive activity of the S1P-receptor agonist FTY720. Journal of cellular and molecular medicine\| PubMed ID: 18494940	2008
Dimethylcelecoxib inhibits prostaglandin E2 production. Biochemical pharmacology\| PubMed ID: 18508034	2008
The anti-proliferative potency of celecoxib is not a class effect of coxibs. Biochemical pharmacology\| PubMed ID: 18547544	2008
The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy? FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18559989	2008
Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not ros... Molecular pharmacology\| PubMed ID: 18599600	2008
Celecoxib inhibits 5-lipoxygenase. Biochemical pharmacology\| PubMed ID: 18692027	2008
Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. Pain\| PubMed ID: 18701217	2008
The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis. Journal of lipid research\| PubMed ID: 18711209	2009
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18716216	2008
Toponomics analysis of functional interactions of the ubiquitin ligase PAM (Protein Associated with Myc) during spinal nociceptive processing. Molecular & cellular proteomics : MCP\| PubMed ID: 18753128	2008
Sphingosine 1-phosphate modulates spinal nociceptive processing. The Journal of biological chemistry\| PubMed ID: 18805787	2008
Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice. European journal of pain (London, England)\| PubMed ID: 18938093	2009
Update on the pathobiology of neuropathic pain. Expert review of proteomics\| PubMed ID: 19086860	2008
A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain. The Journal of biological chemistry\| PubMed ID: 19116204	2009
The S1P(2) receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes. Basic research in cardiology\| PubMed ID: 19139947	2009
Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. Pharmacogenetics and genomics\| PubMed ID: 19214140	2009
Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. Journal of hypertension\| PubMed ID: 19226702	2009
Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2). European journal of pharmacology\| PubMed ID: 19249295	2009
Ceramide synthases and ceramide levels are increased in breast cancer tissue. Carcinogenesis\| PubMed ID: 19279183	2009
Capturing adenylyl cyclases as potential drug targets. Nature reviews. Drug discovery\| PubMed ID: 19337273	2009
Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution. Pharmacogenetics and genomics\| PubMed ID: 19373123	2009
Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation? Pain\| PubMed ID: 19395173	2009
No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing. Trends in neurosciences\| PubMed ID: 19414201	2009
Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers. Pharmacogenetics and genomics\| PubMed ID: 19514130	2009
Genetic modulation of the pharmacological treatment of pain. Pharmacology & therapeutics\| PubMed ID: 19615406	2009
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype. International journal of cancer\| PubMed ID: 19618460	2009
Cellular membranes function as a storage compartment for celecoxib. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 19641861	2009
Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19648270	2009
Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing. Journal of proteome research\| PubMed ID: 19697962	2009
Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia. Pain\| PubMed ID: 19762153	2009
Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19828806	2009
Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care. The Clinical journal of pain\| PubMed ID: 19851158	2009
Highly sensitive determination of HCV protease inhibitors boceprevir (SCH 503034) and telaprevir (VX 950) in human plasma by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 19864192	2009
Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol. Journal of medicinal chemistry\| PubMed ID: 20025212	2010
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations. Cellular and molecular life sciences : CMLS\| PubMed ID: 20091083	2010
An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes. Cell and tissue research\| PubMed ID: 20165884	2010
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. Blood\| PubMed ID: 20197547	2010
Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20224052	2010
Analysis of NF-kappaB signaling pathways by proteomic approaches. Expert review of proteomics\| PubMed ID: 20377387	2010
Ziconotide for treatment of severe chronic pain. Lancet (London, England)\| PubMed ID: 20413151	2010
Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20445053	2010
A critical appraisal of human genotyping for pain therapy. Trends in pharmacological sciences\| PubMed ID: 20483491	2010
Higher pain scores, similar opioid doses and side effects associated with antipyretic analgesics in specialised tertiary pain care. Inflammation research : official journal of the European Histamine Research Society ... [et al.]\| PubMed ID: 20490889	2010
R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PloS one\| PubMed ID: 20498712	2010
Epigenetics in pain and analgesia: an imminent research field. European journal of pain (London, England)\| PubMed ID: 20584621	2011
Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-κB. Biochemical pharmacology\| PubMed ID: 20688046	2010
Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease. PloS one\| PubMed ID: 20694143	2010
Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide. Biochemical pharmacology\| PubMed ID: 20735991	2010
Pharmacogenetics of new analgesics. British journal of pharmacology\| PubMed ID: 20942817	2011
Localization of an endocannabinoid system in the hypophysial pars tuberalis and pars distalis of man. Cell and tissue research\| PubMed ID: 20957495	2010
Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation. The Journal of biological chemistry\| PubMed ID: 21075851	2011
The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling. The Journal of biological chemistry\| PubMed ID: 21098484	2011
Screening for IL28B gene variants identifies predictors of hepatitis C therapy success. Antiviral therapy\| PubMed ID: 21149916	2010
Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy: protection against anemia in patients with chronic hepatitis C. Pharmacogenetics and genomics\| PubMed ID: 21346688	2011
MicroRNAs as new players in the pain game. Pain\| PubMed ID: 21353390	2011
SNO-ing at the nociceptive synapse? Pharmacological reviews\| PubMed ID: 21436345	2011
Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21450910	2011
Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain. PloS one\| PubMed ID: 21572518	2011
CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21813679	2011
The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21813779	2011
Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia. The Journal of biological chemistry\| PubMed ID: 21849511	2011
Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2. Behavioural brain research\| PubMed ID: 21924294	2012
Inhibitors of specific ceramide synthases. Biochimie\| PubMed ID: 21945810	2012
Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation. Molecular pain\| PubMed ID: 21970373	2011
Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1. Cellular signalling\| PubMed ID: 21983014	2012
Low-dose drug combinations along molecular pathways could maximize therapeutic effectiveness while minimizing collateral adverse effects. Drug discovery today\| PubMed ID: 22016087	2011
Single and combined IL28B, ITPA and SLC28A3 host genetic markers modulating response to anti-hepatitis C therapy. Pharmacogenomics\| PubMed ID: 22118055	2011
Chain length-specific properties of ceramides. Progress in lipid research\| PubMed ID: 22133871	2012
Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury. PloS one\| PubMed ID: 22195029	2011
Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth. The international journal of biochemistry & cell biology\| PubMed ID: 22230369	2012
Identification of DNA-protein complexes using an improved, combined western blotting-electrophoretic mobility shift assay (WEMSA) with a fluorescence imaging system. Molecular bioSystems\| PubMed ID: 22358373	2012
Sniffing out pharmacology: interactions of drugs with human olfaction. Trends in pharmacological sciences\| PubMed ID: 22361590	2012
The pharmacogenetic background of hepatitis C treatment. Mutation research\| PubMed ID: 22409946	2012
Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1). Journal of medicinal chemistry\| PubMed ID: 22449023	2012
Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections. PloS one\| PubMed ID: 22457773	2012
Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22544924	2012
5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22553041	2012
Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury. The journal of pain : official journal of the American Pain Society\| PubMed ID: 22564672	2012
Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction. Circulation\| PubMed ID: 22589381	2012
Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation. Prostaglandins & other lipid mediators\| PubMed ID: 22732087	2012
The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors. Behavioural brain research\| PubMed ID: 22732262	2012
Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages. International journal of cancer\| PubMed ID: 22753274	2013
NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22836249	2012
Necessity and risks of arterial blood sampling in healthy volunteer studies. Clinical pharmacokinetics\| PubMed ID: 23018527	2012
Pharmacokinetics of non-intravenous formulations of fentanyl. Clinical pharmacokinetics\| PubMed ID: 23100195	2013
NOXious signaling in pain processing. Pharmacology & therapeutics\| PubMed ID: 23146925	2013
Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23283344	2013
Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage. PloS one\| PubMed ID: 23284665	2012
Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice. Pain\| PubMed ID: 23318130	2013
Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 23371449	2013
Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury. Antioxidants & redox signaling\| PubMed ID: 23495831	2013
The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS. The international journal of biochemistry & cell biology\| PubMed ID: 23538298	2013
Functional genomics of pain in analgesic drug development and therapy. Pharmacology & therapeutics\| PubMed ID: 23567662	2013
Proteomics and NF-κB: an update. Expert review of proteomics\| PubMed ID: 23573785	2013
Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets. Expert review of neurotherapeutics\| PubMed ID: 23621309	2013
Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A₄. Biochemical pharmacology\| PubMed ID: 23643932	2013
Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity. Biochemical pharmacology\| PubMed ID: 23684692	2013
Opioids for chronic non-cancer pain. BMJ (Clinical research ed.)\| PubMed ID: 23719636	2013
Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 23775505	2013
Ceramide metabolism in mouse tissue. The international journal of biochemistry & cell biology\| PubMed ID: 23792024	2013
Exogenous delta⁹-tetrahydrocannabinol influences circulating endogenous cannabinoids in humans. Journal of clinical psychopharmacology\| PubMed ID: 23899642	2013
Activation of the AMP-activated protein kinase reduces inflammatory nociception. The journal of pain : official journal of the American Pain Society\| PubMed ID: 23916727	2013
Prostacyclin regulates spinal nociceptive processing through cyclic adenosine monophosphate-induced translocation of glutamate receptors. Anesthesiology\| PubMed ID: 23969560	2014
Common non-epigenetic drugs as epigenetic modulators. Trends in molecular medicine\| PubMed ID: 24054876	2013
Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1. Bioorganic & medicinal chemistry\| PubMed ID: 24183739	2013
Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation. Antioxidants & redox signaling\| PubMed ID: 24206143	2014
TRP-channels as key integrators of lipid pathways in nociceptive neurons. Progress in lipid research\| PubMed ID: 24287369	2014
BKCa channels expressed in sensory neurons modulate inflammatory pain in mice. Pain\| PubMed ID: 24333777	2014
Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages. Pain\| PubMed ID: 24333781	2014
Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. PloS one\| PubMed ID: 24349046	2013
PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis. Biochemical pharmacology\| PubMed ID: 24355567	2014
Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury. Antioxidants & redox signaling\| PubMed ID: 24450940	2014
Similar maximum systemic but not local cyclooxygenase-2 inhibition by 50 mg lumiracoxib and 90 mg etoricoxib: a randomized controlled trial in healthy subjects. Pharmaceutical research\| PubMed ID: 24469906	2014
Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses. Diabetologia\| PubMed ID: 24488024	2014
Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation. Journal of leukocyte biology\| PubMed ID: 24555986	2014
Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 24649882	2015
LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR. Biochemical and biophysical research communications\| PubMed ID: 24732361	2014
Genome-wide transcriptional profiling of skin and dorsal root ganglia after ultraviolet-B-induced inflammation. PloS one\| PubMed ID: 24732968	2014
Consequences of a human TRPA1 genetic variant on the perception of nociceptive and olfactory stimuli. PloS one\| PubMed ID: 24752136	2014
Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing. Anesthesiology\| PubMed ID: 24758774	2014
Lipoxin A₄: problems with its determination using reversed phase chromatography-tandem mass spectrometry and confirmation with chiral chromatography. Talanta\| PubMed ID: 24913860	2014
Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice. Pharmacology, biochemistry, and behavior\| PubMed ID: 25042778	2014
Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators. Journal of chromatography. A\| PubMed ID: 25124229	2014
Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity. Pain\| PubMed ID: 25139590	2014
Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent. Biochemical pharmacology\| PubMed ID: 25173988	2014
R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO molecular medicine\| PubMed ID: 25269445	2014
Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain. Nature reviews. Neurology\| PubMed ID: 25366108	2014
Role of telaprevir plasma levels for predicting response to antiviral therapy in patients with hepatitis C virus genotype 1 infection. Scandinavian journal of gastroenterology\| PubMed ID: 25384840	2014
Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells. Biochemical pharmacology\| PubMed ID: 25451689	2014
Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans. Oncoscience\| PubMed ID: 25594019	2014
Slack channels expressed in sensory neurons control neuropathic pain in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25609627	2015
Pattern of neuropathic pain induced by topical capsaicin application in healthy subjects. Pain\| PubMed ID: 25687540	2015
Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils. Brain, behavior, and immunity\| PubMed ID: 25697397	2015
Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. Biological chemistry\| PubMed ID: 25720064	2015
Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry. Analytical and bioanalytical chemistry\| PubMed ID: 25749797	2015
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils. Immunology and cell biology\| PubMed ID: 25833068	2015
MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer. Oncotarget\| PubMed ID: 25871398	2015
Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo. Frontiers in neuroscience\| PubMed ID: 25954148	2015
TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes. Journal of neuroinflammation\| PubMed ID: 25997745	2015
AMP-activated protein kinase is activated by non-steroidal anti-inflammatory drugs. European journal of pharmacology\| PubMed ID: 26049010	2015
Rhythmic control of endocannabinoids in the rat pineal gland. Chronobiology international\| PubMed ID: 26061461	2015
Activation of AMPK and its Impact on Exercise Capacity. Sports medicine (Auckland, N.Z.)\| PubMed ID: 26186961	2015
The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain. Brain research\| PubMed ID: 26271715	2015
AMP-activated protein kinase suppresses arachidonate 15-lipoxygenase expression in interleukin 4-polarized human macrophages. The Journal of biological chemistry\| PubMed ID: 26276392	2015
Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 26289316	2015
Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice. International journal of molecular sciences\| PubMed ID: 26593904	2015
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators. Journal of medicinal chemistry\| PubMed ID: 26595749	2016
In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse. PloS one\| PubMed ID: 26599340	2015
S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26603156	2016
Small molecules with anti-inflammatory properties in clinical development. Pharmacology & therapeutics\| PubMed ID: 26627986	2016
Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE. European journal of immunology\| PubMed ID: 26648339	2016
Drug Repurposing for the Development of Novel Analgesics. Trends in pharmacological sciences\| PubMed ID: 26706620	2016
The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model. Biochemical pharmacology\| PubMed ID: 26793999	2016
The impact of endurance exercise on global and AMPK gene-specific DNA methylation. Biochemical and biophysical research communications\| PubMed ID: 27103439	2016
PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells. Acta physiologica (Oxford, England)\| PubMed ID: 27124368	2016