Keigi Fujiwara

Department of Cardiology, University of Texas MD Anderson Cancer Center

Affiliated withUniversity of Texas MD Anderson Cancer Center University of Texas MD Anderson Cancer Center

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2017

Other Publications

Article	Year
Vascular endothelial cells that express dystroglycan are involved in angiogenesis. Journal of cell science\| PubMed ID: 11896196	2002
Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule? The Journal of cell biology\| PubMed ID: 12177047	2002
Mechanical stresses keep endothelial cells healthy: beneficial effects of a physiological level of cyclic stretch on endothelial barrier function. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12959924	2003
Endothelial cell-cell adhesion and mechanosignal transduction. Endothelium : journal of endothelial cell research\| PubMed ID: 15203879	2004
Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. American journal of physiology. Cell physiology\| PubMed ID: 16928770	2007
Down-regulation of ERK but not MEK phosphorylation in cultured endothelial cells by repeated changes in cyclic stretch. Cardiovascular research\| PubMed ID: 17289004	2007
ECM remodeling in hypertensive heart disease. The Journal of clinical investigation\| PubMed ID: 17332884	2007
Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cells. Endothelium : journal of endothelial cell research\| PubMed ID: 18568953	2008
Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation. The Journal of cell biology\| PubMed ID: 18710921	2008
Physiologic stress-mediated signaling in the endothelium. Methods in enzymology\| PubMed ID: 18772009	2008
Collagen I matrix turnover is regulated by fibronectin polymerization. American journal of physiology. Cell physiology\| PubMed ID: 20107040	2010
PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5. Blood\| PubMed ID: 20538799	2010
MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. Blood\| PubMed ID: 21131586	2011
PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. The Journal of cell biology\| PubMed ID: 21624955	2011
Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Basic research in cardiology\| PubMed ID: 22012077	2011
Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 22076424	2011
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circulation research\| PubMed ID: 22267842	2012
Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2. Circulation research\| PubMed ID: 22267843	2012
Glucagon-like peptide-1 and its cardiovascular effects. Current atherosclerosis reports\| PubMed ID: 22878937	2012
Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation. International journal of inflammation\| PubMed ID: 22991685	2012
p62 binding to protein kinase C ζ regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23023376	2012
Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 lig... Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23202365	2013
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation\| PubMed ID: 23243209	2013
De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis. Circulation research\| PubMed ID: 23381569	2013
Shear stress and atherosclerosis. Molecules and cells\| PubMed ID: 24781409	2014
Intima modifier locus 2 controls endothelial cell activation and vascular permeability. Physiological genomics\| PubMed ID: 24986958	2014
ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis. Circulation\| PubMed ID: 25001623	2014
Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agen... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25187658	2014
Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. The Journal of clinical investigation\| PubMed ID: 25689261	2015
Mitochondrial dynamics regulate neointima formation. Cardiovascular research\| PubMed ID: 25800033	2015
Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 25862828	2015
PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation and signaling. Cellular signalling\| PubMed ID: 26706435	2016
Flow signaling and atherosclerosis. Cellular and molecular life sciences : CMLS\| PubMed ID: 28039525	2017
Sub-cellular localization specific SUMOylation in the heart. Biochimica et biophysica acta\| PubMed ID: 28130202	2017
Coordination of Cellular Localization-Dependent Effects of Sumoylation in Regulating Cardiovascular and Neurological Diseases. Advances in experimental medicine and biology\| PubMed ID: 28197922	2017
STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28302626	2017