Gertjan J.L. Kaspers

Pediatric Oncology/Hematology, VU University medical center

Affiliated withVU University medical center Princess Máxima Center for Pediatric Oncology

Research Area

Cancer Research

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2018

Other Publications

Article	Year
Alpe d'HuZes cancer rehabilitation (A-CaRe) research: four randomized controlled exercise trials and economic evaluations in cancer patients and survivors. International journal of behavioral medicine\| PubMed ID: 21556821	2012
Congenital leukaemia: the Dutch experience and review of the literature. British journal of haematology\| PubMed ID: 12028017	2002
Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities. Blood\| PubMed ID: 12384437	2002
Clinical significance of cellular drug resistance in childhood leukemia. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer\| PubMed ID: 12528809	2003
Past, current and future protocols for combined modality therapy in childhood medulloblastoma. Expert review of anticancer therapy\| PubMed ID: 12597352	2003
The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis. Biochemical pharmacology\| PubMed ID: 12628490	2003
FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance. Blood\| PubMed ID: 12816873	2003
Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochemical pharmacology\| PubMed ID: 15041471	2004
The effect of G-CSF on the in vitro cytotoxicity of cytarabine and fludarabine in the FLAG combination in pediatric acute myeloid leukemia. International journal of oncology\| PubMed ID: 15547723	2004
Immunophenotypic cell lineage and in vitro cellular drug resistance in childhood relapsed acute lymphoblastic leukaemia. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 15869873	2005
Use of the differential staining cytotoxicity assay to predict chemosensitivity. Methods in molecular medicine\| PubMed ID: 15901926	2005
6th International Symposium and expert workshops on Leukemia and Lymphoma. 17-19 March, 2005, Amsterdam, The Netherlands. Expert review of anticancer therapy\| PubMed ID: 16001949	2005
In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib: identification of T-cell ALL and FAB M5 AML as the most sensitive subsets. Blood\| PubMed ID: 16051737	2005
Treatment of childhood acute myeloid leukemia. Expert review of anticancer therapy\| PubMed ID: 16221060	2005
Low efficacy of methotrexate in childhood acute myeloid leukemia (AML): single-agent therapeutic window study in relapsed AML. Pediatric blood & cancer\| PubMed ID: 16358301	2006
In vitro sensitivity and cross-resistance to deoxynucleoside analogs in childhood acute leukemia. Haematologica\| PubMed ID: 16434366	2006
Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of cross-resistance to glucocorticoids. Arthritis and rheumatism\| PubMed ID: 16447232	2006
Clinical implications of FLT3 mutations in pediatric AML. Blood\| PubMed ID: 16912228	2006
A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor. Virology\| PubMed ID: 17184803	2007
Sulfasalazine sensitises human monocytic/macrophage cells for glucocorticoids by upregulation of glucocorticoid receptor alpha and glucocorticoid induced apoptosis. Annals of the rheumatic diseases\| PubMed ID: 17267514	2007
Enhanced tumor cell kill by combined treatment with a small-molecule antagonist of mouse double minute 2 and adenoviruses encoding p53. Molecular cancer therapeutics\| PubMed ID: 17513604	2007
Pediatric acute myeloid leukemia: towards high-quality cure of all patients. Haematologica\| PubMed ID: 18024401	2007
Intravenous administration of the conditionally replicative adenovirus Ad5-Delta24RGD induces regression of osteosarcoma lung metastases. Molecular cancer\| PubMed ID: 18215325	2008
The usefulness of growth hormone treatment for psychological status in young adult survivors of childhood leukaemia: an open-label study. BMC pediatrics\| PubMed ID: 18570650	2008
Role of tyrosine phosphatase inhibitors in cancer treatment with emphasis on SH2 domain-containing tyrosine phosphatases (SHPs). Anti-cancer agents in medicinal chemistry\| PubMed ID: 19199865	2009
Old drug, new lessons. Blood\| PubMed ID: 19423737	2009
Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study. Blood\| PubMed ID: 19528532	2009
Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment. PloS one\| PubMed ID: 19536293	2009
Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. British journal of haematology\| PubMed ID: 19775302	2010
FLT3 and KIT mutated pediatric acute myeloid leukemia (AML) samples are sensitive in vitro to the tyrosine kinase inhibitor SU11657. Leukemia research\| PubMed ID: 20435347	2010
Strategies for the analysis of in vitro radiation sensitivity and prediction of interaction with potential radiation modifying agents. International journal of radiation biology\| PubMed ID: 20470196	2010
Pediatric oncologists' attitudes towards involving adolescents in decision-making concerning research participation. Pediatric blood & cancer\| PubMed ID: 20486177	2010
A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia. Blood\| PubMed ID: 20538803	2010
High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine. Blood\| PubMed ID: 20592250	2010
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer cell\| PubMed ID: 20832752	2010
Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia. Haematologica\| PubMed ID: 20971820	2011
Design of the Quality of Life in Motion (QLIM) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of a combined physical exercise and psychosocial trai... BMC cancer\| PubMed ID: 21070639	2010
Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia. Haematologica\| PubMed ID: 21134981	2011
Fatigue in children: reliability and validity of the Dutch PedsQLâ„¢ Multidimensional Fatigue Scale. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation\| PubMed ID: 21246290	2011
Cystatin C more accurately detects mildly impaired renal function than creatinine in children receiving treatment for malignancy. Pediatric blood & cancer\| PubMed ID: 21462304	2011
Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia: an exploratory study. Health and quality of life outcomes\| PubMed ID: 21496357	2011
Cell sensitivity assays: the MTT assay. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21516412	2011
WEE1 inhibition sensitizes osteosarcoma to radiotherapy. BMC cancer\| PubMed ID: 21529352	2011
Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study. Blood\| PubMed ID: 21551233	2011
Cost-effectiveness of treatment of childhood acute lymphoblastic leukemia with chemotherapy only: the influence of new medication and diagnostic technology. Pediatric blood & cancer\| PubMed ID: 21618420	2011
Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia. Haematologica\| PubMed ID: 21791472	2011
Blood pressure and body composition in long-term survivors of childhood acute lymphoblastic leukemia. Pediatric blood & cancer\| PubMed ID: 21793179	2012
Using web-based and paper-based questionnaires for collecting data on fertility issues among female childhood cancer survivors: differences in response characteristics. Journal of medical Internet research\| PubMed ID: 21955527	2011
Effect of corruption on medical care in low-income countries. Pediatric blood & cancer\| PubMed ID: 22106048	2012
PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. Oncotarget\| PubMed ID: 22184287	2011
Malignant melanoma as second malignant neoplasm in long-term childhood cancer survivors: a systematic review. Pediatric blood & cancer\| PubMed ID: 22232079	2012
Pediatric acute myeloid leukemia. Expert review of anticancer therapy\| PubMed ID: 22369331	2012
Value of routine bone marrow examination in pediatric acute myeloid leukemia (AML): a study of the Dutch Childhood Oncology Group (DCOG). Pediatric blood & cancer\| PubMed ID: 22378688	2012
Hypothalamic-pituitary-adrenal axis function in survivors of childhood acute lymphoblastic leukemia and healthy controls. Psychoneuroendocrinology\| PubMed ID: 22385687	2012
Health-related quality of life and utility scores in short-term survivors of pediatric acute lymphoblastic leukemia. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation\| PubMed ID: 22547048	2013
Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatric blood & cancer\| PubMed ID: 22887764	2013
A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges. BMC cancer\| PubMed ID: 22917040	2012
WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas. Molecular cancer therapeutics\| PubMed ID: 23270927	2013
Improved outcome in pediatric relapsed acute myeloid leukemia: results of a randomized trial on liposomal daunorubicin by the International BFM Study Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 23319696	2013
Cost-analysis of treatment of childhood acute lymphoblastic leukemia with asparaginase preparations: the impact of expensive chemotherapy. Haematologica\| PubMed ID: 23403311	2013
Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia. Leukemia\| PubMed ID: 23426163	2013
Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. The Cochrane database of systematic reviews\| PubMed ID: 23633361	2013
In vitro drug response and efflux transporters associated with drug resistance in pediatric high grade glioma and diffuse intrinsic pontine glioma. PloS one\| PubMed ID: 23637844	2013
Health status utilities in pediatrics: a systematic review of acute lymphoblastic leukemia. Medical decision making : an international journal of the Society for Medical Decision Making\| PubMed ID: 23886678	2014
Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: a call for standardization. Pediatric blood & cancer\| PubMed ID: 23907811	2014
Adequate endocrine and cardiovascular response to social stress in survivors of childhood acute lymphoblastic leukemia. Psychoneuroendocrinology\| PubMed ID: 23972944	2013
Higher ratio immune versus constitutive proteasome level as novel indicator of sensitivity of pediatric acute leukemia cells to proteasome inhibitors. Haematologica\| PubMed ID: 24056819	2013
Height-independent estimation of glomerular filtration rate in children: an alternative to the Schwartz equation. The Journal of pediatrics\| PubMed ID: 24094878	2013
Why pediatricians fail to diagnose hypertension: a multicenter survey. The Journal of pediatrics\| PubMed ID: 24120124	2014
High resolution SNP array profiling identifies variability in retinoblastoma genome stability. Genes, chromosomes & cancer\| PubMed ID: 24249257	2014
Childhood lymphomatoid granulomatosis: a report of 2 cases and review of the literature. Journal of pediatric hematology/oncology\| PubMed ID: 24390446	2014
Interferon-γ-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines. Journal of hematology & oncology\| PubMed ID: 24418325	2014
t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients. Haematologica\| PubMed ID: 24441146	2014
A prospective study on drug monitoring of PEGasparaginase and Erwinia asparaginase and asparaginase antibodies in pediatric acute lymphoblastic leukemia. Blood\| PubMed ID: 24449211	2014
Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration. Neuro-oncology\| PubMed ID: 24470547	2014
EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma. Oncotarget\| PubMed ID: 24495907	2014
Anti-leukemic activity and mechanisms underlying resistance to the novel immunoproteasome inhibitor PR-924. Biochemical pharmacology\| PubMed ID: 24552657	2014
Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib). Molecular pharmacology\| PubMed ID: 24737138	2014
Human pontine glioma cells can induce murine tumors. Acta neuropathologica\| PubMed ID: 24777482	2014
Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis. Scientific reports\| PubMed ID: 24919120	2014
Determinants of quality of life during induction therapy in pediatric acute lymphoblastic leukemia. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer\| PubMed ID: 25011520	2014
Relevance of leukemic stem cells in acute myeloid leukemia: heterogeneity and influence on disease monitoring, prognosis and treatment design. Expert review of hematology\| PubMed ID: 25242511	2014
Convection enhanced delivery of carmustine to the murine brainstem: a feasibility study. Journal of neuroscience methods\| PubMed ID: 25263805	2014
Factors influencing childhood cancer patients to participate in a combined physical and psychosocial intervention program: Quality of Life in Motion. Psycho-oncology\| PubMed ID: 25285989	2015
A twenty-year review of diagnosing and treating children with diffuse intrinsic pontine glioma in The Netherlands. Expert review of anticancer therapy\| PubMed ID: 25435089	2015
Pre-mRNA splicing in cancer: the relevance in oncogenesis, treatment and drug resistance. Expert opinion on drug metabolism & toxicology\| PubMed ID: 25495223	2015
Applicability and evaluation of a psychosocial intervention program for childhood cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer\| PubMed ID: 25577501	2015
Molecular basis of resistance to proteasome inhibitors in hematological malignancies. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy\| PubMed ID: 25670156	2015
No efficacy for silicone gel sheeting in prevention of abnormal scar formation in children with cancer: a randomized controlled trial. Plastic and reconstructive surgery\| PubMed ID: 25811573	2015
Gene expression profiles associated with pediatric relapsed AML. PloS one\| PubMed ID: 25849371	2015
Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia. Journal of hematology & oncology\| PubMed ID: 26022503	2015
Comparing Health-Care Providers' Perspectives on Complementary and Alternative Medicine in Childhood Cancer Between Netherlands and Indonesia. Pediatric blood & cancer\| PubMed ID: 26274831	2016
Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia. The Cochrane database of systematic reviews\| PubMed ID: 26282194	2015
Palliative and end-of-life care for children with diffuse intrinsic pontine glioma: results from a London cohort study and international survey. Neuro-oncology\| PubMed ID: 26459800	2016
Effects of a combined physical and psychosocial intervention program for childhood cancer patients on quality of life and psychosocial functioning: results of the QLIM randomized clinical tr... Psycho-oncology\| PubMed ID: 26509236	2016
Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance. International journal of cancer\| PubMed ID: 26547381	2016
Cardiorespiratory fitness and physical activity in children with cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer\| PubMed ID: 26581899	2016
Recurrent translocation t(10;17)(p15;q21) in minimally differentiated acute myeloid leukemia results in ZMYND11/MBTD1 fusion. Genes, chromosomes & cancer\| PubMed ID: 26608508	2016
miR expression profiling at diagnosis predicts relapse in pediatric precursor B-cell acute lymphoblastic leukemia. Genes, chromosomes & cancer\| PubMed ID: 26684414	2016
Screening for Psychosocial Risk in Dutch Families of a Child With Cancer: Reliability, Validity, and Usability of the Psychosocial Assessment Tool. Journal of pediatric psychology\| PubMed ID: 26715054	2016
Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. Molecular & cellular proteomics : MCP\| PubMed ID: 26801919	2016
A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer. Oncotarget\| PubMed ID: 26967057	2016
Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. The Cochrane database of systematic reviews\| PubMed ID: 27030386	2016
The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia. Haematologica\| PubMed ID: 27036162	2016
A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression. PloS one\| PubMed ID: 27115612	2016
Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes. Scientific reports\| PubMed ID: 27126562	2016
State of affairs in use of steroids in diffuse intrinsic pontine glioma: an international survey and a review of the literature. Journal of neuro-oncology\| PubMed ID: 27177627	2016
Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models. Molecular cancer therapeutics\| PubMed ID: 27325687	2016
Real-world implementation of electronic patient-reported outcomes in outpatient pediatric cancer care. Psycho-oncology\| PubMed ID: 27502744	2017
Proteasome subunit expression analysis and chemosensitivity in relapsed paediatric acute leukaemia patients receiving bortezomib-containing chemotherapy. Journal of hematology & oncology\| PubMed ID: 27599459	2016
Genomic landscape of retinoblastoma in Rbp130mice resembles human retinoblastoma. Genes, chromosomes & cancer\| PubMed ID: 27750399	2017
Strategies for reducing the treatment-related physical burden of childhood acute myeloid leukaemia - a review. British journal of haematology\| PubMed ID: 27766626	2017
An 8-Year-Old Girl with Ocular Swelling. The Journal of pediatrics\| PubMed ID: 27855997	2017
Chemotherapy-related late adverse effects on ovarian function in female survivors of childhood and young adult cancer: A systematic review. Cancer treatment reviews\| PubMed ID: 28056411	2017
Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease. Journal of neuro-oncology\| PubMed ID: 28110411	2017
Population pharmacokinetics of intravenous Erwinia asparaginase in pediatric acute lymphoblastic leukemia patients. Haematologica\| PubMed ID: 28250007	2017
Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma. Journal of neurosurgery. Pediatrics\| PubMed ID: 28291423	2017
External validation of the diffuse intrinsic pontine glioma survival prediction model: a collaborative report from the International DIPG Registry and the SIOPE DIPG Registry. Journal of neuro-oncology\| PubMed ID: 28560664	2017
A phase I/II study of gemcitabine during radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma. Journal of neuro-oncology\| PubMed ID: 28748343	2017
A cost analysis of individualized asparaginase treatment in pediatric acute lymphoblastic leukemia. Pediatric blood & cancer\| PubMed ID: 28766887	2017
Multiregional tumor drug-uptake imaging by PET and microvascular morphology in end-stage diffuse intrinsic pontine glioma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 28818988	2017
Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies. Experimental cell research\| PubMed ID: 28947132	2017
Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma. Oncotarget\| PubMed ID: 28947983	2017
Correction to: A phase I/II study of gemcitabine during radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma. Journal of neuro-oncology\| PubMed ID: 29063425	2018
Leukaemic stem cell load at diagnosis predicts the development of relapse in young acute myeloid leukaemia patients. British journal of haematology\| PubMed ID: 29076143	2017
Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma. Oncotarget\| PubMed ID: 29108280	2017
Effective Drug Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model to Identify Potential Candidates. Frontiers in oncology\| PubMed ID: 29164054	2017
Signaling pathways and mesenchymal transition in pediatric high-grade glioma. Cellular and molecular life sciences : CMLS\| PubMed ID: 29164272	2018
Clinical challenges in de novo pediatric acute myeloid leukemia. Expert review of anticancer therapy\| PubMed ID: 29338495	2018