George M. Church

Wyss Institute for Biologically Inspired Engineering, Harvard University

Affiliated withHarvard University Harvard Medical School Wyss Institute for Biologically Inspired Engineering

Research Area

GeneticsBioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2018
Publication title	2019

Other Publications

Article	Year
Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11404456	2001
Nucleotides of transcription factor binding sites exert interdependent effects on the binding affinities of transcription factors. Nucleic acids research\| PubMed ID: 11861919	2002
A motif co-occurrence approach for genome-wide prediction of transcription-factor-binding sites in Escherichia coli. Genome research\| PubMed ID: 14762058	2004
The complete genome and proteome of Mycoplasma mobile. Genome research\| PubMed ID: 15289470	2004
Genomic analysis of LexA binding reveals the permissive nature of the Escherichia coli genome and identifies unconventional target sites. Genes & development\| PubMed ID: 16264194	2005
The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting. Molecular cell\| PubMed ID: 17157257	2006
The most conserved genome segments for life detection on Earth and other planets. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life\| PubMed ID: 18853276	2008
Rapid prototyping of 3D DNA-origami shapes with caDNAno. Nucleic acids research\| PubMed ID: 19531737	2009
Programming cells by multiplex genome engineering and accelerated evolution. Nature\| PubMed ID: 19633652	2009
Free Factories: Unified Infrastructure for Data Intensive Web Services. Proceedings of the USENIX ... annual Technical Conference. USENIX Technical Conference\| PubMed ID: 20514356	2008
Reprogramming of T cells from human peripheral blood. Cell stem cell\| PubMed ID: 20621044	2010
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nature biotechnology\| PubMed ID: 21248753	2011
A new dawn for industrial photosynthesis. Photosynthesis research\| PubMed ID: 21318462	2011
Autoantigen discovery with a synthetic human peptidome. Nature biotechnology\| PubMed ID: 21602805	2011
Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. Science (New York, N.Y.)\| PubMed ID: 21764749	2011
High-throughput multiplex sequencing of miRNA. Current protocols in human genetics\| PubMed ID: 22470142	2012
Genome-scale promoter engineering by coselection MAGE. Nature methods\| PubMed ID: 22484848	2012
Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection. Nucleic acids research\| PubMed ID: 22638574	2012
A BioBrick compatible strategy for genetic modification of plants. Journal of biological engineering\| PubMed ID: 22716313	2012
Multiplexed in vivo His-tagging of enzyme pathways for in vitro single-pot multienzyme catalysis. ACS synthetic biology\| PubMed ID: 22737598	2012
How accurate can genetic predictions be? BMC genomics\| PubMed ID: 22827772	2012
Improving lambda red genome engineering in Escherichia coli via rational removal of endogenous nucleases. PloS one\| PubMed ID: 22957093	2012
Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA. Nature chemistry\| PubMed ID: 23000997	2012
RNA-guided human genome engineering via Cas9. Science (New York, N.Y.)\| PubMed ID: 23287722	2013
PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. Journal of autoimmunity\| PubMed ID: 23497938	2013
Barcoding cells using cell-surface programmable DNA-binding domains. Nature methods\| PubMed ID: 23503053	2013
Nanotools for neuroscience and brain activity mapping. ACS nano\| PubMed ID: 23514423	2013
Research, collaboration, and open science using web 2.0. Journal of microbiology & biology education\| PubMed ID: 23653712	2010
Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nature methods\| PubMed ID: 23817069	2013
Optical control of mammalian endogenous transcription and epigenetic states. Nature\| PubMed ID: 23877069	2013
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nature biotechnology\| PubMed ID: 23907171	2013
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nature biotechnology\| PubMed ID: 23929339	2013
Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system. Genetics\| PubMed ID: 23979579	2013
Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria. Nucleic acids research\| PubMed ID: 24049072	2014
Cas9 as a versatile tool for engineering biology. Nature methods\| PubMed ID: 24076990	2013
Genomically recoded organisms expand biological functions. Science (New York, N.Y.)\| PubMed ID: 24136966	2013
Physical principles for scalable neural recording. Frontiers in computational neuroscience\| PubMed ID: 24187539	2013
The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS pathogens\| PubMed ID: 24278016	2013
The role of replicates for error mitigation in next-generation sequencing. Nature reviews. Genetics\| PubMed ID: 24322726	2014
Rational optimization of tolC as a powerful dual selectable marker for genome engineering. Nucleic acids research\| PubMed ID: 24452804	2014
Highly multiplexed subcellular RNA sequencing in situ. Science (New York, N.Y.)\| PubMed ID: 24578530	2014
Realizing the potential of synthetic biology. Nature reviews. Molecular cell biology\| PubMed ID: 24622617	2014
High-resolution antibody dynamics of vaccine-induced immune responses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24639495	2014
Syntrophic exchange in synthetic microbial communities. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24778240	2014
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature medicine\| PubMed ID: 24813252	2014
Direct mutagenesis of thousands of genomic targets using microarray-derived oligonucleotides. ACS synthetic biology\| PubMed ID: 24856730	2015
CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing. Nucleic acids research\| PubMed ID: 24861617	2014
Genome editing assessment using CRISPR Genome Analyzer (CRISPR-GA). Bioinformatics (Oxford, England)\| PubMed ID: 24990609	2014
Multiplex single-molecule interaction profiling of DNA-barcoded proteins. Nature\| PubMed ID: 25252978	2014
Engineering allostery. Trends in genetics : TIG\| PubMed ID: 25306102	2014
Rapid neurogenesis through transcriptional activation in human stem cells. Molecular systems biology\| PubMed ID: 25403753	2014
Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells. Nucleic acids research\| PubMed ID: 25414332	2015
Evolution-guided optimization of biosynthetic pathways. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25453111	2014
Biocontainment of genetically modified organisms by synthetic protein design. Nature\| PubMed ID: 25607366	2015
Spatial information in large-scale neural recordings. Frontiers in computational neuroscience\| PubMed ID: 25653613	2014
Highly efficient Cas9-mediated transcriptional programming. Nature methods\| PubMed ID: 25730490	2015
Synthetic biosensors for precise gene control and real-time monitoring of metabolites. Nucleic acids research\| PubMed ID: 26152303	2015
Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach. Nature methods\| PubMed ID: 26167643	2015
Bioart. Trends in biotechnology\| PubMed ID: 26617334	2015
Engineering an allosteric transcription factor to respond to new ligands. Nature methods\| PubMed ID: 26689263	2016
Tools for the Microbiome: Nano and Beyond. ACS nano\| PubMed ID: 26695070	2016
A general strategy to construct small molecule biosensors in eukaryotes. eLife\| PubMed ID: 26714111	2015
In vivo gene editing in dystrophic mouse muscle and muscle stem cells. Science (New York, N.Y.)\| PubMed ID: 26721686	2016
Genetically encoded sensors enable real-time observation of metabolite production. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26858408	2016
Multiplexed Engineering in Biology. Trends in biotechnology\| PubMed ID: 26897356	2016
Biosensor-based engineering of biosynthetic pathways. Current opinion in biotechnology\| PubMed ID: 26998575	2016
Nucleic acid memory. Nature materials\| PubMed ID: 27005909	2016
Real-time single-molecule electronic DNA sequencing by synthesis using polymer-tagged nucleotides on a nanopore array. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27091962	2016
Precision Chemistry for Precision Medicine. ACS central science\| PubMed ID: 27162939	2015
Molecular recordings by directed CRISPR spacer acquisition. Science (New York, N.Y.)\| PubMed ID: 27284167	2016
Design, synthesis, and testing toward a 57-codon genome. Science (New York, N.Y.)\| PubMed ID: 27540174	2016
CRISPR-Cas9 System: Opportunities and Concerns. Clinical chemistry\| PubMed ID: 27551006	2016
A multifunctional AAV-CRISPR-Cas9 and its host response. Nature methods\| PubMed ID: 27595405	2016
Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27601680	2016
Design and characterization of a nanopore-coupled polymerase for single-molecule DNA sequencing by synthesis on an electrode array. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27729524	2016
Complete mitochondrial genomes of living and extinct pigeons revise the timing of the columbiform radiation. BMC evolutionary biology\| PubMed ID: 27782796	2016
Rapidly evolving homing CRISPR barcodes. Nature methods\| PubMed ID: 27918539	2017
Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. Nature protocols\| PubMed ID: 27929521	2017
Cushing's syndrome mutant PKA exhibits altered substrate specificity. FEBS letters\| PubMed ID: 28100013	2017
sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity. ACS synthetic biology\| PubMed ID: 28146356	2017
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nature microbiology\| PubMed ID: 28165460	2017
An unbiased index to quantify participant's phenotypic contribution to an open-access cohort. Scientific reports\| PubMed ID: 28387241	2017
Evolutionary dynamics of CRISPR gene drives. Science advances\| PubMed ID: 28435878	2017
Nucleotide-time alignment for molecular recorders. PLoS computational biology\| PubMed ID: 28459860	2017
Optimizing complex phenotypes through model-guided multiplex genome engineering. Genome biology\| PubMed ID: 28545477	2017
Millstone: software for multiplex microbial genome analysis and engineering. Genome biology\| PubMed ID: 28545559	2017
Scalable Device for Automated Microbial Electroporation in a Digital Microfluidic Platform. ACS synthetic biology\| PubMed ID: 28569062	2017
CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. Nature\| PubMed ID: 28700573	2017
Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nature neuroscience\| PubMed ID: 28714951	2017
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. Science (New York, N.Y.)\| PubMed ID: 28798043	2017
Extracellular Vesicle Isolation and Analysis by Western Blotting. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28828654	2017
Imaging of Isolated Extracellular Vesicles Using Fluorescence Microscopy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28828661	2017
Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues. Nano letters\| PubMed ID: 28933153	2017
Heterologous erythromycin production across strain and plasmid construction. Biotechnology progress\| PubMed ID: 28960932	2018
DNA sequencing at 40: past, present and future. Nature\| PubMed ID: 29019985	2017
Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Nature biomedical engineering\| PubMed ID: 29038743	2017
A CRISPR-Cas9-based gene drive platform for genetic interaction analysis in Candida albicans. Nature microbiology\| PubMed ID: 29062088	2017
Engineering posttranslational proofreading to discriminate nonstandard amino acids. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29301968	2018
From Designing the Molecules of Life to Designing Life: Future Applications Derived from Advances in DNA Technologies. Angewandte Chemie (International ed. in English)\| PubMed ID: 29316123	2018
Spontaneous CRISPR loci generation in vivo by non-canonical spacer integration. Nature microbiology\| PubMed ID: 29379209	2018
Adaptive evolution of genomically recoded . Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29440500	2018
Precise Cas9 targeting enables genomic mutation prevention. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29555762	2018
Enabling multiplexed testing of pooled donor cells through whole-genome sequencing. Genome medicine\| PubMed ID: 29673390	2018
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Cell\| PubMed ID: 29677511	2018
High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing. Nucleic acids research\| PubMed ID: 29718339	2018
Codon usage of highly expressed genes affects proteome-wide translation efficiency. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29735666	2018
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast. Nature biotechnology\| PubMed ID: 29786095	2018
Current CRISPR gene drive systems are likely to be highly invasive in wild populations. eLife\| PubMed ID: 29916367	2018
Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks. Molecular cell\| PubMed ID: 29979968	2018
Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip. Nature protocols\| PubMed ID: 29995874	2018
An enhanced CRISPR repressor for targeted mammalian gene regulation. Nature methods\| PubMed ID: 30013045	2018
Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators. Nature communications\| PubMed ID: 30082754	2018
Developmental barcoding of whole mouse via homing CRISPR. Science (New York, N.Y.)\| PubMed ID: 30093604	2018