Sidney Strickland

Patricia and John Rosenwald Laboratory of Neurobiology and Genetics, Rockefeller University

Research Area

Biochemistry

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2018

Other Publications

Article	Year
Tissue plasminogen activator in nervous system function and dysfunction. Thrombosis and haemostasis\| PubMed ID: 11486999	2001
Localization and regulation of the tissue plasminogen activator-plasmin system in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11896152	2002
Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation. Neuron\| PubMed ID: 11906694	2002
Nervous system pathology: the fibrin perspective. Biological chemistry\| PubMed ID: 11928820	2002
Tissue plasminogen activator and seizures: a clot-buster's secret life. The Journal of clinical investigation\| PubMed ID: 12070298	2002
Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior. Nature neuroscience\| PubMed ID: 12524546	2003
Fibrin is a regulator of Schwann cell migration after sciatic nerve injury in mice. Neuroscience letters\| PubMed ID: 12581827	2003
The hippocampal laminin matrix is dynamic and critical for neuronal survival. Molecular biology of the cell\| PubMed ID: 12857855	2003
The possible role of tissue-type plasminogen activator (tPA) and tPA blockers in the pathogenesis and treatment of Alzheimer's disease. Journal of molecular neuroscience : MN\| PubMed ID: 14501010	2003
The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14523088	2003
Laminin gamma1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve. The Journal of cell biology\| PubMed ID: 14638863	2003
Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15096619	2004
Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15522965	2004
Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15630096	2005
Tissue plasminogen activator in central nervous system physiology and pathology. Thrombosis and haemostasis\| PubMed ID: 15841309	2005
Schwann cell-specific ablation of laminin gamma1 causes apoptosis and prevents proliferation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15872093	2005
Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16330749	2005
The plasminogen activator system modulates sympathetic nerve function. The Journal of experimental medicine\| PubMed ID: 16940168	2006
Peripheral regeneration. Annual review of neuroscience\| PubMed ID: 17341159	2007
Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. The Journal of experimental medicine\| PubMed ID: 17664291	2007
Modulation of NR2B-regulated contextual fear in the hippocampus by the tissue plasminogen activator system. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17673549	2007
Key role of tissue plasminogen activator in neurovascular coupling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18195371	2008
Disruption of laminin in the peripheral nervous system impedes nonmyelinating Schwann cell development and impairs nociceptive sensory function. Glia\| PubMed ID: 19053061	2009
Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor. The Journal of cell biology\| PubMed ID: 19114596	2008
Cortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration. Developmental biology\| PubMed ID: 19118544	2009
Tissue plasminogen activator modulates the cellular and behavioral response to cocaine. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19181855	2009
Laminin is required for Schwann cell morphogenesis. Journal of cell science\| PubMed ID: 19295124	2009
Plasmin-mediated degradation of laminin gamma-1 is critical for ethanol-induced neurodegeneration. Biological psychiatry\| PubMed ID: 19577227	2009
Maximum-entropy network analysis reveals a role for tumor necrosis factor in peripheral nerve development and function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19597151	2009
Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease. Neuron\| PubMed ID: 20547128	2010
Involvement of tissue plasminogen activator in stress responsivity during acute cocaine withdrawal in mice. Stress (Amsterdam, Netherlands)\| PubMed ID: 20666641	2010
Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21098282	2010
Mesenchymal stem cells facilitate axon sorting, myelination, and functional recovery in paralyzed mice deficient in Schwann cell-derived laminin. Glia\| PubMed ID: 21125647	2011
Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21383198	2011
Renal collecting system growth and function depend upon embryonic γ1 laminin expression. Development (Cambridge, England)\| PubMed ID: 21903675	2011
Aβ delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin. Blood\| PubMed ID: 22238323	2012
Schwann cell myelination requires integration of laminin activities. Journal of cell science\| PubMed ID: 22767514	2012
Fibrinogen and altered hemostasis in Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 22869464	2012
The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration. Neuroscience\| PubMed ID: 23357115	2013
The APOE ɛ4/ɛ4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 23652625	2013
Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke. The Journal of cell biology\| PubMed ID: 23857767	2013
Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity. Nature communications\| PubMed ID: 24583950	2014
Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 24612416	2014
A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice. The Journal of experimental medicine\| PubMed ID: 24821909	2014
The cellular origin of laminin determines its role in blood pressure regulation. Cellular and molecular life sciences : CMLS\| PubMed ID: 25216704	2015
Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration. Neurobiology of aging\| PubMed ID: 25475538	2015
Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25775543	2015
Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer's Disease. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 25941345	2015
The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 26613657	2016
Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 27090576	2016
Laminin regulates PDGFRβ(+) cell stemness and muscle development. Nature communications\| PubMed ID: 27138650	2016
A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease. Thrombosis research\| PubMed ID: 27207427	2016
Biochemical and structural analysis of the interaction between β-amyloid and fibrinogen. Blood\| PubMed ID: 27389717	2016
Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice. Blood\| PubMed ID: 28242605	2017
Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease. Current opinion in hematology\| PubMed ID: 28661939	2017
Fibrinogen in the Nervous System: Glia Beware. Neuron\| PubMed ID: 29216454	2017
Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation. Biochemistry\| PubMed ID: 29394041	2018
Abnormal clotting of the intrinsic/contact pathway in Alzheimer disease patients is related to cognitive ability. Blood advances\| PubMed ID: 29700007	2018
Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30254165	2018
A novel detection method of cleaved plasma high-molecular-weight kininogen reveals its correlation with Alzheimer's pathology and cognitive impairment. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 30310850	2018