Guy A. Caldwell

Department of Biological Sciences, University of Alabama

Research Area

Biology

Biography

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JoVE Journal Publications

Article Total : 2	Year
Publication title	2008
Publication title	2008

Other Publications

Article	Year
Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins. Human molecular genetics\| PubMed ID: 12554684	2003
Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. Journal of cell science\| PubMed ID: 12679384	2003
An animal model to discern torsin function: suppression of protein aggregation in C. elegans. Advances in neurology\| PubMed ID: 14509658	2004
Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride based ionic liquids. Chemical communications (Cambridge, England)\| PubMed ID: 15010772	2004
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. Human molecular genetics\| PubMed ID: 15254012	2004
MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain. Current biology : CB\| PubMed ID: 15530389	2004
Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15829632	2005
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (New York, N.Y.)\| PubMed ID: 16794039	2006
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16807328	2006
Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain research\| PubMed ID: 16996038	2006
Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. BMC cell biology\| PubMed ID: 17663792	2007
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18162536	2008
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18182484	2008
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease. Neuroscience letters\| PubMed ID: 18514411	2008
The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro. Cell stress & chaperones\| PubMed ID: 18626791	2009
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Molecular brain\| PubMed ID: 19021916	2008
Traversing a wormhole to combat Parkinson's disease. Disease models & mechanisms\| PubMed ID: 19048050	2008
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nature genetics\| PubMed ID: 19182805	2009
Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nature chemical biology\| PubMed ID: 19597508	2009
Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission. Genetics\| PubMed ID: 19797046	2009
Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration. PloS one\| PubMed ID: 19806188	2009
VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiology of disease\| PubMed ID: 19850127	2010
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Disease models & mechanisms\| PubMed ID: 20038714	2010
C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 20108318	2010
The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro. Cell stress & chaperones\| PubMed ID: 20169475	2010
Chemical enhancement of torsinA function in cell and animal models of torsion dystonia. Disease models & mechanisms\| PubMed ID: 20223934	2010
Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. Journal of neurochemistry\| PubMed ID: 20534000	2010
The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response. Human molecular genetics\| PubMed ID: 20584926	2010
Caenorhabditis elegans as a model system for identifying effectors of Î±-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease. Methods (San Diego, Calif.)\| PubMed ID: 21195766	2011
Gaucher disease glucocerebrosidase and Î±-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell\| PubMed ID: 21700325	2011
TorsinA participates in endoplasmic reticulum-associated degradation. Nature communications\| PubMed ID: 21750546	2011
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Human molecular genetics\| PubMed ID: 21768216	2011
Modeling dopamine neuron degeneration in Caenorhabditis elegans. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21913098	2011
Functional links between AÎ² toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (New York, N.Y.)\| PubMed ID: 22033521	2011
Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, Î±-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms. The Journal of biological chemistry\| PubMed ID: 22147697	2012
Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis elegans and Mammalian Models of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22323726	2012