Armin Buschauer

Institute of Pharmacy, University of Regensburg

Research Area

BiochemistryUnit 1

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2020

Other Publications

Article	Year
Polyamine levels of human colorectal adenocarcinomas are correlated with tumor stage and grade. International journal of colorectal disease\| PubMed ID: 12355213	2002
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. The Journal of clinical investigation\| PubMed ID: 12417570	2002
Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells. The Journal of biological chemistry\| PubMed ID: 14701802	2004
L-Ascorbic acid 6-hexadecanoate, a potent hyaluronidase inhibitor. X-ray structure and molecular modeling of enzyme-inhibitor complexes. The Journal of biological chemistry\| PubMed ID: 15322107	2004
Structure-activity relationships of histamine H2 receptor ligands. Mini reviews in medicinal chemistry\| PubMed ID: 15544555	2004
Construction and validation of a microprocessor controlled extracorporal circuit in rats for the optimization of isolated limb perfusion. Archiv der Pharmazie\| PubMed ID: 15597400	2004
Sulphated oligosaccharides as inhibitors of hyaluronidases from bovine testis, bee venom and Streptococcus agalactiae. Planta medica\| PubMed ID: 16142636	2005
Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole. Glycobiology\| PubMed ID: 16638841	2006
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells. Cancer chemotherapy and pharmacology\| PubMed ID: 16703323	2007
Platelet-derived growth factor receptor independent proliferation of human glioblastoma cells: selective tyrosine kinase inhibitors lack antiproliferative activity. Journal of cancer research and clinical oncology\| PubMed ID: 16736141	2006
A simple and powerful flow cytometric method for the simultaneous determination of multiple parameters at G protein-coupled receptor subtypes. Chembiochem : a European journal of chemical biology\| PubMed ID: 16888730	2006
Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases. Bioorganic & medicinal chemistry letters\| PubMed ID: 16908142	2006
Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y2 receptor ligands. European journal of pharmacology\| PubMed ID: 17027743	2006
Constitutive activity and ligand selectivity of human, guinea pig, rat, and canine histamine H2 receptors. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17332265	2007
Mutations of Cys-17 and Ala-271 in the human histamine H2 receptor determine the species selectivity of guanidine-type agonists and increase constitutive activity. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17347323	2007
Isoenzyme-specific differences in the degradation of hyaluronic acid by mammalian-type hyaluronidases. Glycoconjugate journal\| PubMed ID: 17620008	2008
Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice. Journal of cancer research and clinical oncology\| PubMed ID: 17932689	2008
Frontiers in medicinal chemistry in Regensburg. ChemMedChem\| PubMed ID: 18655207	2008
Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Journal of medicinal chemistry\| PubMed ID: 18950149	2008
Guanidine-acylguanidine bioisosteric approach in the design of radioligands: synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]-UR-MK114) as a highly potent and selective neurop... Journal of medicinal chemistry\| PubMed ID: 19053784	2008
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. Journal of medicinal chemistry\| PubMed ID: 19170519	2009
N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent. Journal of medicinal chemistry\| PubMed ID: 19317445	2009
Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists. Journal of medicinal chemistry\| PubMed ID: 19791743	2009
Chiral NG-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity. Bioorganic & medicinal chemistry letters\| PubMed ID: 20409707	2010
G protein-coupled receptors function as logic gates for nanoparticle binding and cell uptake. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20498042	2010
Histamine H4 receptor agonists. Bioorganic & medicinal chemistry letters\| PubMed ID: 21044842	2010
Expression and functional properties of canine, rat, and murine histamine H₄ receptors in Sf9 insect cells. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 21359967	2011
Functional reconstitution of human neuropeptide Y (NPY) Y(2) and Y(4) receptors in Sf9 insect cells. Journal of receptor and signal transduction research\| PubMed ID: 21745157	2011
Role of the second and third extracellular loops of the histamine H(4) receptor in receptor activation. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 21800093	2011
Fast counter-electroosmotic capillary electrophoresis-time-of-flight mass spectrometry of hyaluronan oligosaccharides. Analytical and bioanalytical chemistry\| PubMed ID: 21800126	2012
Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase. European journal of medicinal chemistry\| PubMed ID: 21803461	2011
Synthesis and histamine H(3) and H(4) receptor activity of conformationally restricted cyanoguanidines related to UR-PI376. Archiv der Pharmazie\| PubMed ID: 21987304	2011
The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H₂ receptor agonists. Journal of medicinal chemistry\| PubMed ID: 22216892	2012
Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs. Trends in pharmacological sciences\| PubMed ID: 23228711	2013
The neuropeptide y y(1) receptor: a diagnostic marker? Expression in mcf-7 breast cancer cells is down-regulated by antiestrogens in vitro and in xenografts. PloS one\| PubMed ID: 23236424	2012
Molecular and cellular analysis of human histamine receptor subtypes. Trends in pharmacological sciences\| PubMed ID: 23254267	2013
Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity. PloS one\| PubMed ID: 23741338	2013
Luciferase reporter gene assay on human, murine and rat histamine H4 receptor orthologs: correlations and discrepancies between distal and proximal readouts. PloS one\| PubMed ID: 24023919	2013
Dimeric argininamide-type neuropeptide Y receptor antagonists: chiral discrimination between Y1 and Y4 receptors. Bioorganic & medicinal chemistry\| PubMed ID: 24074877	2013
Replacement of Thr32 and Gln34 in the C-terminal neuropeptide Y fragment 25-36 by cis-cyclobutane and cis-cyclopentane β-amino acids shifts selectivity toward the Y(4) receptor. Journal of medicinal chemistry\| PubMed ID: 24090364	2013
Synthesis and dual histamine H₁ and H₂ receptor antagonist activity of cyanoguanidine derivatives. Molecules (Basel, Switzerland)\| PubMed ID: 24248146	2013
Synthesis and functional characterization of imbutamine analogs as histamine H3 and H4 receptor ligands. Archiv der Pharmazie\| PubMed ID: 24493592	2014
Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators. ACS medicinal chemistry letters\| PubMed ID: 24900683	2013
No evidence for histamine H4 receptor in human monocytes. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 25273276	2014
The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity. PloS one\| PubMed ID: 25629160	2015
Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists. Bioorganic & medicinal chemistry\| PubMed ID: 25639885	2015
M2 Subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: Effect of chemical homo-dimerization on orthosteric (and allosteric?) binding. Bioorganic & medicinal chemistry\| PubMed ID: 25650309	2015
High performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) for the sensitive determination of hyaluronan oligosaccharides. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 25768984	2015
Toward Labeled Argininamide-Type NPY Y1 Receptor Antagonists: Identification of a Favorable Propionylation Site in BIBO3304. Archiv der Pharmazie\| PubMed ID: 25884646	2015
Topotecan-induced ABCG2 expression in MCF-7 cells is associated with decreased CD24 and EpCAM expression and a loss of tumorigenicity. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 25892097	2015
Esters of Bendamustine Are by Far More Potent Cytotoxic Agents than the Parent Compound against Human Sarcoma and Carcinoma Cells. PloS one\| PubMed ID: 26196503	2015
Histamine H(1)- and H(4)-receptor signaling cooperatively regulate MAPK activation. Biochemical pharmacology\| PubMed ID: 26385311	2015
Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization. European journal of medicinal chemistry\| PubMed ID: 26774038	2016
Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptid... Journal of medicinal chemistry\| PubMed ID: 26824643	2016
BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells. Oncotarget\| PubMed ID: 26893360	2016
Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H4 Receptor Agonists. Journal of medicinal chemistry\| PubMed ID: 27007611	2016
High Affinity Agonists of the Neuropeptide Y (NPY) Y4 Receptor Derived from the C-Terminal Pentapeptide of Human Pancreatic Polypeptide (hPP): Synthesis, Stereochemical Discrimination, and R... Journal of medicinal chemistry\| PubMed ID: 27223253	2016
Prototypic F-Labeled Argininamide-Type Neuropeptide Y YR Antagonists as Tracers for PET Imaging of Mammary Carcinoma. ACS medicinal chemistry letters\| PubMed ID: 28337321	2017
Fluorescence- and Radiolabeling of [Lys,Nle]hPP Yields Molecular Tools for the NPY Y Receptor. Bioconjugate chemistry\| PubMed ID: 28345900	2017
Molecular Mechanisms of Biased and Probe-Dependent Signaling at CXC-Motif Chemokine Receptor CXCR3 Induced by Negative Allosteric Modulators. Molecular pharmacology\| PubMed ID: 29343553	2018
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nature structural & molecular biology\| PubMed ID: 29610494	2018
Structural basis of ligand binding modes at the neuropeptide Y Y receptor. Nature\| PubMed ID: 29670288	2018
In Search of NPY YR Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists. ACS omega\| PubMed ID: 30023699	2017
Tariquidar-Related Chalcones and Ketones as ABCG2 Modulators. ACS medicinal chemistry letters\| PubMed ID: 30128080	2018
Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H Receptor Agonists. ACS omega\| PubMed ID: 30221224	2018
A split luciferase-based probe for quantitative proximal determination of Gα signalling in live cells. Scientific reports\| PubMed ID: 30464299	2018
Alkyl derivatives of 1,3,5-triazine as histamine H receptor ligands. Bioorganic & medicinal chemistry\| PubMed ID: 30792106	2019
Split luciferase-based assay for simultaneous analyses of the ligand concentration- and time-dependent recruitment of β-arrestin2. Analytical biochemistry\| PubMed ID: 30853375	2019
[H]UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H Receptors. Journal of medicinal chemistry\| PubMed ID: 31469288	2019
Basal Histamine H Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 31498478	2019