Timothy Block

Hepatitis B virus large and middle glycoproteins are degraded by a proteasome pathway in glucosidase-inhibited cells but not in cells with functional glucosidase enzyme.

Proteomic analysis of serum associated fucosylated glycoproteins in the development of primary hepatocellular carcinoma.

Does rapid oligomerization of hepatitis B envelope proteins play a role in resistance to proteasome degradation and enhance chronicity?

The role of the downstream signal sequences in the maturation of the HBV middle surface glycoprotein: development of a novel therapeutic vaccine candidate.

Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway.

The degradation pathway for the HBV envelope proteins involves proteolysis prior to degradation via the cytosolic proteasome.

Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation.

A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.

Alpha interferon-induced antiviral response noncytolytically reduces replication defective adenovirus DNA in MDBK cells.

Molecular virology of hepatitis B virus for clinicians.

N-linked glycosylation of the liver cancer biomarker GP73.

Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis.

Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus.

The degree of readiness of selected biomarkers for the early detection of hepatocellular carcinoma: notes from a recent workshop.

Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells.

Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells.

Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I.

Fucosylated glycoproteins as markers of liver disease.

Rapid and sensitive detection of hepatitis B virus 1762T/1764A double mutation from hepatocellular carcinomas using LNA-mediated PCR clamping and hybridization probes.

Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses.

Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma.

Antiviral activity of geneticin against dengue virus.

Antiviral effect of interferon lambda against West Nile virus.

Production and function of the cytoplasmic deproteinized relaxed circular DNA of hepadnaviruses.

Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.

Interferons accelerate decay of replication-competent nucleocapsids of hepatitis B virus.

Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks.

Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma.

Evidence that herpes simplex virus DNA derived from quiescently infected cells in vitro, and latently infected cells in vivo, is physically damaged.

Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo.

Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells.

Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses.

Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release.

Novel changes in glycosylation of serum Apo-J in patients with hepatocellular carcinoma.

Ultrasensitive quantification of hepatitis B virus A1762T/G1764A mutant by a SimpleProbe PCR using a wild-type-selective PCR blocker and a primer-blocker-probe partial-overlap approach.

Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis.

A locked nucleic acid clamp-mediated PCR assay for detection of a p53 codon 249 hotspot mutation in urine.

Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.

Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.

Development of recombinant Aleuria aurantia lectins with altered binding specificities to fucosylated glycans.

A ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein to limit antigen presentation.

Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma.

Hepatocellular carcinoma of the liver.

Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion.

Detection of hypermethylated vimentin in urine of patients with colorectal cancer.

Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue.

Impact of the location of CpG methylation within the GSTP1 gene on its specificity as a DNA marker for hepatocellular carcinoma.

Direct evidence that HSV DNA damaged by ultraviolet (UV) irradiation can be repaired in a cell type-dependent manner.

Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation.

Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection.

Characterization of the host factors required for hepadnavirus covalently closed circular (ccc) DNA formation.

Substance abuse, HIV-1 and hepatitis.

RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response.

The innate immune response to hepatitis B virus infection: implications for pathogenesis and therapy.

Interleukin-6 and oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73.

Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells.

Defining the value proposition of biotech therapies.

Chronic hepatitis B: what should be the goal for new therapies?

Surrogate markers of efficacy for medical treatment of viral hepatitis.

Sulfamoylbenzamide derivatives inhibit the assembly of hepatitis B virus nucleocapsids.

Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.

Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection.

Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions.

A southern blot assay for detection of hepatitis B virus covalently closed circular DNA from cell cultures.

Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein.

Total serum glycan analysis is superior to lectin-FLISA for the early detection of hepatocellular carcinoma.

Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes.

Improved biomarker performance for the detection of hepatocellular carcinoma by inclusion of clinical parameters.

Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.

An interferon-beta promoter reporter assay for high throughput identification of compounds against multiple RNA viruses.

Viral resistance of MOGS-CDG patients implies a broad-spectrum strategy against acute virus infections.

Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2.

Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis.

STING agonists induce an innate antiviral immune response against hepatitis B virus.

Glycosylation and liver cancer.

Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues.

Imino sugar glucosidase inhibitors as broadly active anti-filovirus agents.

Data supporting updating estimates of the prevalence of chronic hepatitis B and C in the United States.

The Doylestown Algorithm: A Test to Improve the Performance of AFP in the Detection of Hepatocellular Carcinoma.

Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA.

Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo.