Pia K. Kuusisto

Bee and wasp sting reactions in current beekeepers.

Epidemiological evidence for the association of hyperglycaemia and atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus.

Stability of age-associated memory impairment during a longitudinal population-based study.

The Ala54Thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects.

Detection of Chlamydia pneumoniae in human nonrheumatic stenotic aortic valves.

The importance of fluorescence distribution and kinetics of ALA-induced PpIX in the bladder in photodynamic therapy.

Protoporphyrin-IX distribution and photodynamic effect in rat oesophagus after aminolaevulinic acid administration.

The Trp64Arg polymorphism of the beta 3-Adrenergic receptor gene. Lack of association with NIDDM and features of insulin resistance syndrome.

Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study.

New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.

Time-resolved fluorescence imaging in islet cell autoantibody quantitation.

Cognitive function in an elderly population with persistent impaired glucose tolerance.

Comparison of the oral health status and salivary flow rate of asthmatic patients with those of nonasthmatic adults--results of a pilot study.

Randomised comparison of cost effectiveness of guided self management and traditional treatment of asthma in Finland.

Can degenerative aortic valve stenosis be related to persistent Chlamydia pneumoniae infection?

Stimulated salivary flow rate and composition in asthmatic and non-asthmatic adults.

Lymphocyte subpopulations, cytokine release and specific immunoglobulin G in reactive and nonreactive beekeepers.

Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.

Expression of seizure-related PTZ-17 is induced by potassium deprivation in cerebellar granule cells.

The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population.

Pogosta disease: clinical observations during an outbreak in the province of North Karelia, Finland.

Exopolysaccharide-producing bacteria from sugar beets.

Prandial glucose regulation and cardiovascular disease in type 2 diabetes.

Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men.

Type-2 diabetes and cognitive function in a non-demented population.

Simultaneous hypertrophic cardiomyopathy and ventricular septal defect in children.

LDL size and risk of coronary heart disease in elderly men and women.

Epidemiological study of nephropathia epidemica in Finland 1989-96.

The cardiac troponin I gene is not associated with hypertrophic cardiomyopathy in patients from eastern Finland.

A differential display protocol to identify differentially expressed mRNAs in potassium-deprived cerebellar granule cells.

Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin.

[The pathogenesis of aortic valvular stenosis will soon be known].

The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia.

Historical trends in lake and river ice cover in the northern hemisphere

Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes.

Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes.

Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study.

Prolonged arthritis associated with sindbis-related (Pogosta) virus infection.

Insulin-like growth factor binding protein 5 and type-1 insulin-like growth factor receptor are differentially regulated during apoptosis in cerebellar granule cells.

Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells.

APOE-epsilon4 is associated with weight loss in women with AD: a population-based study.

Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies.

New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes.

Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men.

[Sarcomere gene mutations--a cause of hypertrophic cardiomyopathy].

Occurrence and destruction of PAHs, PCBs, CIPhs, CIBzs, and PCDD/Fs in ash from gasification of straw.

Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation.

No variants in the cardiac actin gene in Finnish patients with dilated or hypertrophic cardiomyopathy.

Prolonged arthritis associated with Sindbis-related (Pogosta) virus infection.

Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland.

Epidemiology of Sindbis virus infections in Finland 1981-96: possible factors explaining a peculiar disease pattern.

First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the Asp175Asn mutation of the alpha-tropomyosin gene.

Cardiac adrenergic activity is associated with left ventricular hypertrophy in genetically homogeneous subjects with hypertrophic cardiomyopathy.

[Cases of oculopharyngeal muscular dystrophy even in Finland].

[Problematic fever].

[NARP syndrome--a less known mitochondrial disease].

A novel mutation, Arg71Thr, in the delta-sarcoglycan gene is associated with dilated cardiomyopathy.

A new technique for multiparameter imaging microscopy: use of long decay time photoluminescent labels enables multiple color immunocytochemistry with low channel-to-channel crosstalk.

[Multiple sclerosis in a female patient].

Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

[What new about hypertrophic cardiomyopathy?].

Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene.

Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes.

Increase in CCR5 Delta32/Delta32 genotype in multiple sclerosis.

A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy.

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain.

Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy.

Atherosclerosis-like lesions of the aortic valve are common in adults of all ages: a necropsy study.

Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene.

Enteroviruses and the risk of MS in the Finnish Twin Cohort.

The efficacy of glatiramer acetate in beta-interferon-intolerant MS patients.

Increased disability and MRI lesions after discontinuation of IFN-beta-1a in secondary progressive MS.

Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28.

Periodontal disease and bacterial vaginosis increase the risk for adverse pregnancy outcome.

Effect of high-dose methylprednisolone treatment on CCR5 expression on blood cells in MS exacerbation.

Gene expression profiles in Finnish twins with multiple sclerosis.

Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beta-myosin heavy chain, alpha-tropomyosin, and myosin-binding protein C genes.

Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy.

Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population.

Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes.

[Not Available].

Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene: magnetic resonance imaging study.

Association of metabolic syndrome with Alzheimer disease: a population-based study.

NARP syndrome and adult-onset generalised seizures.

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.

Discovering inhibitors of human sirtuin type 2: novel structural scaffolds.

Time-resolved fluorescence imaging of islet cell autoantibodies.

PCB contaminated dust on indoor surfaces--health risks and acceptable surface concentrations in residential and occupational settings.

N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors.

The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns.

N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors.

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.

Cytokines, interstitial collagen and ventricular remodelling in dilated cardiomyopathy.

Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study.

Once-weekly 22microg subcutaneous IFN-beta-1a in secondary progressive MS: a 3-year follow-up study on brain MRI measurements and serum MMP-9 levels.

The biarsenical dye Lumio exhibits a reduced ability to specifically detect tetracysteine-containing proteins within live cells.

Metabolic syndrome and incident end-stage peripheral vascular disease: a 14-year follow-up study in elderly Finns.

Human herpes virus 6 and multiple sclerosis: a Finnish twin study.

Use of p62/SQSTM1 antibodies for neuropathological diagnosis.

Atherosclerosis and cardiovascular risk reduction with PPAR agonists.

Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans.

Long-term retention rate of entacapone in the treatment of Parkinson's disease.

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.

The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland.

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Significance of plasma levels of N-terminal Pro-B-type natriuretic peptide on left ventricular remodeling in non-obstructive hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene.

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

Clinical significance of troponin I efflux and troponin autoantibodies in patients with dilated cardiomyopathy.

WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.

Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone.

Concordance and heritability of multiple sclerosis in Finland: study on a nationwide series of twins.

Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data.

The C-terminus of apoptin represents a unique tumor cell-enhanced nuclear targeting module.

Association of sequence variations in the gene encoding insulin-like growth factor binding protein 5 with adiponectin.

Apoptosis-related molecules in blood in multiple sclerosis.

High-resolution signal-averaged analysis of atrial electromagnetic characteristics in patients with paroxysmal lone atrial fibrillation.

The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner.

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.

Galanin preproprotein is associated with elevated plasma triglycerides.

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells.

Common variants at 30 loci contribute to polygenic dyslipidemia.

Variants in MTNR1B influence fasting glucose levels.

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

A randomized, double-blind study comparing Clostridium difficile immune whey and metronidazole for recurrent Clostridium difficile-associated diarrhoea: efficacy and safety data of a prematurely interrupted trial.

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes.

Therapeutic activities of intravenous immunoglobulins in multiple sclerosis involve modulation of chemokine expression.

Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men.

The need for comprehensive cardiac and neurologic assessment of lamin A/C mutation carriers.

Long-term retention rate of pramipexole in the treatment of Parkinson's disease.

Genome-wide association study identifies eight loci associated with blood pressure.

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

Elevated cerebrospinal fluid adiponectin and adipsin levels in patients with multiple sclerosis: a Finnish co-twin study.

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Experiences with the electronic nursing discharge summary.

Underlying genetic models of inheritance in established type 2 diabetes associations.

Cardiac sympathetic activity is associated with inflammation and neurohumoral activation in patients with idiopathic dilated cardiomyopathy.

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.

The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose.

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.

The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns.

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.

Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism--the Finnish Diabetes Prevention Study.

Pregnancy and childbirth in carriers of the lamin A/C-gene mutation.

Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study.

Identification of undiagnosed type 2 diabetic individuals by the finnish diabetes risk score and biochemical and genetic markers: a population-based study of 7232 Finnish men.

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells.

Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias.

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

A novel surrogate index for hepatic insulin resistance.

The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies.

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men.

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.

Cardiac MRI assessed left ventricular hypertrophy in differentiating hypertensive heart disease from hypertrophic cardiomyopathy attributable to a sarcomeric gene mutation.

Hospital training program increases awareness of Good Clinical Practice (GCP).

Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy.

Intravenous immunoglobulins are a therapeutic option in the treatment of multiple sclerosis relapse.

Usability of electronic nursing record systems: definition and results from an evaluation study in Finland.

Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals.

Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles.

Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men.

Pre-treatment expectations in clients: impact on retention and effectiveness in outpatient substance abuse treatment.

Late gadolinium enhanced cardiovascular magnetic resonance of lamin A/C gene mutation related dilated cardiomyopathy.

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

Pleiotropic effects of GIP on islet function involve osteopontin.

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.

What is our role in promoting literacy for children who are "blind" or visually impaired?

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Glomerular filtration rate and parathyroid hormone are associated with 1,25-dihydroxyvitamin D in men without chronic kidney disease.

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans.

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.

The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge.

The interplay between lipoprotein phenotypes, adiponectin, and alcohol consumption.

Global enhancement of nuclear localization-dependent nuclear transport in transformed cells.

A genome-wide association search for type 2 diabetes genes in African Americans.

Evaluation of the national nursing model and four nursing documentation systems in Finland - Lessons learned and directions for the future.

Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy.

Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population.

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Association between liver insulin resistance and cardiovascular risk factors.

Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men.

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men.

Circulating TNF-Alpha and IL-6 Concentrations and TNF-Alpha -308 G > A Polymorphism in Children with Premature Adrenarche.

Plasma levels of antibodies against oxidized LDL are inherited but not associated with HDL-cholesterol level in families with early coronary heart disease.

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

Retention rate of selegiline in early Parkinson's disease: a retrospective survey.