Irena Levitan

Section of Respiratory, University of Illinois

Affiliated withUniversity of Illinois University of Illinois at Chicago

Research Area

BioengineeringImmunology and Infection

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2012
Publication title	2019

Other Publications

Article	Year
Dual effect of fluid shear stress on volume-regulated anion current in bovine aortic endothelial cells. American journal of physiology. Cell physiology\| PubMed ID: 11880259	2002
Modulation of endothelial inward-rectifier K+ current by optical isomers of cholesterol. Biophysical journal\| PubMed ID: 12496090	2002
Shear stress increases expression of a KATP channel in rat and bovine pulmonary vascular endothelial cells. American journal of physiology. Cell physiology\| PubMed ID: 12826604	2003
Sensitivity of volume-regulated anion current to cholesterol structural analogues. The Journal of general physiology\| PubMed ID: 14699079	2004
Plasma membrane surface increases with tonic stretch of alveolar epithelial cells. American journal of respiratory cell and molecular biology\| PubMed ID: 15016618	2004
Cholesterol depletion increases membrane stiffness of aortic endothelial cells. Biophysical journal\| PubMed ID: 15347591	2004
Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophysical journal\| PubMed ID: 15465867	2004
Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. American journal of physiology. Cell physiology\| PubMed ID: 15958527	2005
OxLDL increases endothelial stiffness, force generation, and network formation. Journal of lipid research\| PubMed ID: 16418538	2006
Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo. Circulation research\| PubMed ID: 16556870	2006
Relationship between Kir2.1/Kir2.3 activity and their distributions between cholesterol-rich and cholesterol-poor membrane domains. American journal of physiology. Cell physiology\| PubMed ID: 17459945	2007
Hypercholesterolemia suppresses Kir channels in porcine bone marrow progenitor cells in vivo. Biochemical and biophysical research communications\| PubMed ID: 17482574	2007
Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. Biochimica et biophysica acta\| PubMed ID: 17493580	2007
The effect of cellular cholesterol on membrane-cytoskeleton adhesion. Journal of cell science\| PubMed ID: 17550968	2007
Lipid rafts in membrane-cytoskeleton interactions and control of cellular biomechanics: actions of oxLDL. Antioxidants & redox signaling\| PubMed ID: 17576163	2007
oxLDL facilitates flow-induced realignment of aortic endothelial cells. American journal of physiology. Cell physiology\| PubMed ID: 18562483	2008
Endothelial actin and cell stiffness is modulated by substrate stiffness in 2D and 3D. Journal of biomechanics\| PubMed ID: 19356760	2009
Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416905	2009
Cholesterol and Kir channels. IUBMB life\| PubMed ID: 19548316	2009
Direct regulation of prokaryotic Kir channel by cholesterol. The Journal of biological chemistry\| PubMed ID: 19740741	2009
Oxidized LDL: diversity, patterns of recognition, and pathophysiology. Antioxidants & redox signaling\| PubMed ID: 19888833	2010
Comparative analysis of cholesterol sensitivity of Kir channels: role of the CD loop. Channels (Austin, Tex.)\| PubMed ID: 19923917	2010
Cholesterol and ion channels. Sub-cellular biochemistry\| PubMed ID: 20213557	2010
oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation. American journal of physiology. Cell physiology\| PubMed ID: 20410437	2010
Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore. Biophysical journal\| PubMed ID: 21244834	2011
Anthrax lethal factor activates K(+) channels to induce IL-1Î² secretion in macrophages. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21421849	2011
Modification of Cellular Cholesterol Content Affects Traction Force, Adhesion and Cell Spreading. Cellular and molecular bioengineering\| PubMed ID: 21461187	2010
Impact of oxLDL on Cholesterol-Rich Membrane Rafts. Journal of lipids\| PubMed ID: 21490811	2011
Cholesterol regulates prokaryotic Kir channel by direct binding to channel protein. Biochimica et biophysica acta\| PubMed ID: 21798234	2011
Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22101521	2012
Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and GÎ²Î³. The Journal of biological chemistry\| PubMed ID: 22174416	2012
Cholesterol depletion facilitates recovery from hypotonic cell swelling in CHO cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 22179012	2011
New mechanisms of pulmonary arterial hypertension: role of CaÂ²âº signaling. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22245772	2012
The role of oxysterols in control of endothelial stiffness. Journal of lipid research\| PubMed ID: 22496390	2012
OxLDL and substrate stiffness promote neutrophil transmigration by enhanced endothelial cell contractility and ICAM-1. Journal of biomechanics\| PubMed ID: 22560286	2012
Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of Kir channels by cholesterol and PI(4,5)P2. The Journal of biological chemistry\| PubMed ID: 22995912	2012
Regulation of ion channels by membrane lipids. Comprehensive Physiology\| PubMed ID: 23728970	2012
Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini. Channels (Austin, Tex.)\| PubMed ID: 23807091	2013
Identification of novel cholesterol-binding regions in Kir2 channels. The Journal of biological chemistry\| PubMed ID: 24019518	2013
Upregulated copper transporters in hypoxia-induced pulmonary hypertension. PloS one\| PubMed ID: 24614111	2014
Cholesterol binding to ion channels. Frontiers in physiology\| PubMed ID: 24616704	2014
Oxidized low-density lipoprotein alters the effect of matrix stiffness on the formation of endothelial networks and capillary lumens. Pulmonary circulation\| PubMed ID: 24618546	2013
Silencing of Kir2 channels by caveolin-1: cross-talk with cholesterol. The Journal of physiology\| PubMed ID: 25038242	2014
Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2. Computational and structural biotechnology journal\| PubMed ID: 25408847	2014
Cholesterol increases the open probability of cardiac KACh currents. Biochimica et biophysica acta\| PubMed ID: 26196595	2015
Oxidized LDL signals through Rho-GTPase to induce endothelial cell stiffening and promote capillary formation. Journal of lipid research\| PubMed ID: 26989083	2016
Paradoxical impact of cholesterol on lipid packing and cell stiffness. Frontiers in bioscience (Landmark edition)\| PubMed ID: 27100504	2016
Inwardly rectifying K channels are major contributors to flow-induced vasodilatation in resistance arteries. The Journal of physiology\| PubMed ID: 27859264	2017
Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol. Nature chemical biology\| PubMed ID: 28024150	2017
Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids. Biophysical journal\| PubMed ID: 28122218	2017
oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27 signaling: opposite effects of oxLDL and cholesterol loading. American journal of physiology. Cell physiology\| PubMed ID: 28701359	2017
Differential Effects of Sterols on Ion Channels: Stereospecific Binding vs Stereospecific Response. Current topics in membranes\| PubMed ID: 28863819	2017
Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 29025707	2018
Hypotonic Challenge of Endothelial Cells Increases Membrane Stiffness with No Effect on Tether Force. Biophysical journal\| PubMed ID: 29490252	2018
Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K Channels. Journal of the American Heart Association\| PubMed ID: 29502106	2018
Comparative analysis of endothelial cell and sub-endothelial cell elastic moduli in young and aged mice: Role of CD36. Journal of biomechanics\| PubMed ID: 29954596	2018
Molecular Dynamics Simulations of Kir2.2 Interactions with an Ensemble of Cholesterol Molecules. Biophysical journal\| PubMed ID: 30205899	2018
Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus. Current topics in membranes\| PubMed ID: 30243442	2018
Potential Strategies to Reduce Blood Pressure in Treatment-Resistant Hypertension Using Food and Drug Administration-Approved Nanodrug Delivery Platforms. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 30624988	2019
Role of matrix metalloproteinases and histone deacetylase in oxidative stress-induced degradation of the endothelial glycocalyx. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 30632766	2019
Chiral Specificity of Cholesterol Orientation Within Cholesterol Binding Sites in Inwardly Rectifying K Channels. Advances in experimental medicine and biology\| PubMed ID: 30649756	2019
Endothelial stiffening in dyslipidemia. Aging\| PubMed ID: 30674709	2019
Comparative docking analysis of cholesterol analogs to ion channels to discriminate between stereospecific binding vs. stereospecific response. Channels (Austin, Tex.)\| PubMed ID: 31033379	2019
Shear-Stress Sensitive Inwardly-Rectifying K Channels Regulate Developmental Retinal Angiogenesis by Vessel Regression. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 31145841	2019