a-3d-digital-model-for-diagnosis-treatment-pulmonary

A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules

The three-dimensional (3D) reconstruction of pulmonary nodules using medical images has introduced new technical approaches for diagnosing and treating ...

a-three-dimensional-digital-model-for-early-diagnosis-hepatic

A Three-Dimensional Digital Model for Early Diagnosis of Hepatic Fibrosis Based on Magnetic Resonance Elastography

Hepatic fibrosis is an early stage of liver cirrhosis, and there are no better non-invasive and convenient methods for the detection and evaluation of the ...

three-dimensional-reconstruction-for-whole-lung-with-early-multiple

Three-Dimensional Reconstruction for the Whole Lung with Early Multiple Pulmonary Nodules

For patients with early multiple pulmonary nodules, it is essential, from a diagnostic perspective, to determine the spatial distribution, size, location, ...

a-3d-quantification-technique-for-liver-fat-fraction-distribution

A 3D Quantification Technique for Liver Fat Fraction Distribution Analysis Using Dixon Magnetic Resonance Imaging

This study presents a 3D quantification methodology for the distribution of liver fat fraction (LFF) through the utilization of Dixon MRI image analysis. ...

synchronous-triplanar-reconstruction-integrated-with-color-doppler

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

This paper proposes a novel thyroid examination technique based on five-dimensional (5D) synchronous reconstruction of ultrasound data. The raw temporal ...

multifractal-spectrum-analysis-for-assessing-pulmonary-nodule

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy

Non-invasive assessment of pulmonary nodule malignancy remains a critical challenge in lung cancer diagnosis. Traditional methods often lack precision in ...

a-data-driven-approach-to-quantifying-immune-states-in-sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

In sepsis, understanding the interplay among white blood cells, lymphocytes, and neutrophils is crucial for assessing the immune condition and optimizing ...

precise-non-invasive-liver-cirrhosis-quantification-via-multimodal

Precise Non-invasive Liver Cirrhosis Quantification <em>via</em> Multimodal Stiffness-Structural Fusion Imaging

Traditional Magnetic Resonance Elastography (MRE) presents stiffness and structural images separately, requiring manual ROI delineation for liver ...

Dongzhimen Hospital of Beijing University of Chinese Medicine

Beijing University of Chinese Medicine

Affiliated to Beijing University of Chinese Medicine

Viral pneumonia is one kind of acute respiratory tract infection caused by the virus. There have been many outbreaks of viral pneumonia with high contagiousness and mortality both in China and abroad, such as the great influenza in 1918, the severe acute respiratory syndrome (SARS) coronavirus in 2003, the Influenza A (H1N1) virus in 2009, and the Middle East Respiratory Syndrome coronavirus (MERS-CoV) in 2012 and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019. These outbreaks and/or pandemic have significant impact on human life, social behaviors, and economic development. Moreover, no specific drug has been developed for these viruses. Traditional Chinese medicine (TCM) plays an important role in the treatment of viral pneumonia during these outbreaks especially in SARS and SARS-CoV-2 because studies suggest that TCM formulations may target several aspects of the disease and may have lesser side effects than manufactured pharmaceuticals. In recent years, a lot of clinicians and researchers have made a series of in-depth explorations and investigations on the treatment of viral pneumonia with TCM, which have understood TCM therapeutic mechanisms more specifically and clearly. But critical analysis of this research in addition to further studies are needed to assess the potential of TCM in the treatment of viral pneumonia.

Role of Traditional Chinese Medicine in the Management of Viral Pneumonia.

Development of a core outcome set (COS) for clinical trials for COVID-19 is urgent because of the pandemic wreaking havoc worldwide and the heterogeneity of outcomes in clinical trials.

Core Outcome Set for Clinical Trials of COVID-19 Based on Traditional Chinese and Western Medicine.

To evaluate the efficacy of Shenfu decoction (SFD) prepared with a traditional Chinese formula, on sepsis in rats with the condition induced by cecal ligation and puncture (CLP), and to study the possible mechanism underlying its action.

Efficacy of Shenfu decoction on sepsis in rats with condition induced by cecal ligation and puncture.

The continuous evolution of SARS-CoV-2 has underscored the development of broad-spectrum prophylaxis. Antivirals targeting the membrane fusion process represent promising paradigms. Kaempferol (Kae), an ubiquitous plant flavonol, has been shown efficacy against various enveloped viruses. However, its potential in anti-SARS-CoV-2 invasion remains obscure.

Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion.

Non-alcoholic fatty liver disease (NAFLD) is characterized by dysregulated carbohydrate and lipid metabolism, which are its primary features. However, traditional biochemical markers pose challenges for accurate quantification and visualization of metabolic states. This study introduces a novel states-based approach for accurate NAFLD assessment.

Probabilistic Scatter Plots for visualizing carbohydrate and lipid metabolism states in Non-Alcoholic Fatty Liver Disease.

Sepsis is a life-threatening condition and usually be treated with antibiotics, which however often has severe side effects. This work proposed a novel Chinese traditional medicine JINHONG (JH) decoction for therapy of sepsis. We first identified the chemical constituents of JH decoction by using high-performance liquid chromatography and mass spectrometry (HPLC-MS). Then, we constructed a model mouse for sepsis by using cecal ligation and puncture (CLP). Metagenomic sequencing method was used to compare the diversity and abundance of the gut microbiota between normal, disease model, JH decoction-treatment and antibiotic-treatment mice. Many indices including the number of platelets, CD62p and CD63 content, AQP2 and AQP8 level, as well as the expression level of protein C confirmed that the sepsis resulted in serious pathological damage, while all of these indices could be reversed by JH decoction and antibiotics. The diversity and abundance of intestinal flora decreased in CLP mice, and the decrements aggravated after antibiotic treatment while can be recovered by JH decoction treatment. The abundance of anti-inflammatory Ruminococcaceae increased after JH decoction treatment, indicating that JH decoction could ameliorate pathology associated with sepsis in CLP model via modulating the intestinal flora. This study demonstrates that JH decoction could treat sepsis clinically without obvious adverse effects on gut microbiota.

Jinhong decoction ameliorates injury in septic mice without disrupting the equilibrium of gut microbiota.

Hepatitis B Cirrhosis, a severe progression of chronic Hepatitis B infection, requires a comprehensive understanding of the interplay among lymphocyte populations. This study aims to quantify and visualize the relationships among T cells, NK cells, and B cells to aid in assessing immune status, diagnosing the condition, and optimizing treatment strategies.

ArticleTotal : 8	Year
Publication title	2023
Publication title	2023
Publication title	2023
Publication title	2023
Publication title	2024

Article	Year
Role of Traditional Chinese Medicine in the Management of Viral Pneumonia. Frontiers in pharmacology\| PubMed ID: 33192523	2020
Core Outcome Set for Clinical Trials of COVID-19 Based on Traditional Chinese and Western Medicine. Frontiers in pharmacology\| PubMed ID: 32574235	2020
Efficacy of Shenfu decoction on sepsis in rats with condition induced by cecal ligation and puncture. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan\| PubMed ID: 32744029	2020
Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 37421767	2023
Probabilistic Scatter Plots for visualizing carbohydrate and lipid metabolism states in Non-Alcoholic Fatty Liver Disease. Clinics and research in hepatology and gastroenterology\| PubMed ID: 38703816	2024
Jinhong decoction ameliorates injury in septic mice without disrupting the equilibrium of gut microbiota. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 39154578	2024
Quantification and clustering of immune states in hepatitis B Cirrhosis. Immunobiology\| PubMed ID: 40582284	2025

Tengxiao Liang

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