Stephen C. Pflugfelder

Characterization of putative stem cell phenotype in human limbal epithelia.

Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures.

Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface.

Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.

Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca.

ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells.

Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye.

Doxycycline inhibits TGF-beta1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells.

Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness.

Therapy of progressive rheumatoid arthritis-associated corneal ulceration with infliximab.

Effect of experimental dry eye on tear sodium concentration in the mouse.

Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells.

Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface.

JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells.

Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells.

The incidence and risk factors for developing dry eye after myopic LASIK.

Expression and regulation of cornified envelope proteins in human corneal epithelium.

Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye.

Improved transduction of human corneal epithelial progenitor cells with cell-targeting adenoviral vectors.

Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline.

Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium.

Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells.

Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells.

Integrating restasis into the management of dry eye.

Anti-inflammatory therapy of dry eye.

The Ocular Surface Center at the Baylor College of Medicine, Houston.

Management of the late ocular sequelae of Stevens-Johnson syndrome.

Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice.

Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease.

Matrix metalloproteinases in corneal inflammation.

Prominent corneal nerves in a patient with multiple myeloma.

Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways.

Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma.

Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress.

Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress.

Future directions in therapeutic interventions for conjunctival inflammatory disorders.

Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells.

Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions.

Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice.

Bilateral acanthamoeba keratitis.

Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK.

Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production.

Prevalence, burden, and pharmacoeconomics of dry eye disease.

Effects of osmoprotectants on hyperosmolar stress in cultured human corneal epithelial cells.

Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline.

Effects of contact lens multipurpose solutions on human corneal epithelial survival and barrier function.

Epithelial-immune cell interaction in dry eye.

Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs.

Tear cytokine profiles in dysfunctional tear syndrome.

Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.

Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome.

Corneal epithelial opacity in dysfunctional tear syndrome.

Induction of Th17 differentiation by corneal epithelial-derived cytokines.

Toll-like receptors mediate induction of peptidoglycan recognition proteins in human corneal epithelial cells.

Association between high tear epidermal growth factor levels and corneal subepithelial fibrosis in dry eye conditions.

Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome.

Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9.

Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy.

Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice.

Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress.

TSLP and downstream molecules in experimental mouse allergic conjunctivitis.

Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway.

Molecular signatures and biological pathway profiles of human corneal epithelial progenitor cells.

Potential localization of putative stem/progenitor cells in human bulbar conjunctival epithelium.

Altered morphology and function of the lacrimal functional unit in protein kinase C{alpha} knockout mice.

Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells.

Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay.

Spontaneous autoimmune dacryoadenitis in aged CD25KO mice.

Noninvasive assessment of tear stability with the tear stability analysis system in tear dysfunction patients.

Post-LASIK tear dysfunction and dysesthesia.

The successful use of Boston ocular surface prosthesis in the treatment of persistent corneal epithelial defect after herpes zoster ophthalmicus.

Anterior segment optical coherence tomography: a diagnostic instrument for conjunctivochalasis.

An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factor.

The impact of the Boston ocular surface prosthesis on wavefront higher-order aberrations.

Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland.

The β-catenin/Tcf4/survivin signaling maintains a less differentiated phenotype and high proliferative capacity of human corneal epithelial progenitor cells.

Entrapment of conjunctival goblet cells by desiccation-induced cornification.

Interferon-γ exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways.

TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium.

Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways.

Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-γ.

Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture.

Challenges in the clinical measurement of ocular surface disease in glaucoma patients.

Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca.

Transcription Factor TCF4 Maintains the Properties of Human Corneal Epithelial Stem Cells.

Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye.

Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease.

Botulinum toxin injection for the management of refractory filamentary keratitis.

NK cells promote Th-17 mediated corneal barrier disruption in dry eye.

Identification of human fibroblast cell lines as a feeder layer for human corneal epithelial regeneration.

Increasing prevalence and severity of conjunctivochalasis with aging detected by anterior segment optical coherence tomography.

Deletion of interferon-γ delays onset and severity of dacryoadenitis in CD25KO mice.

Morphologic alterations of the palpebral conjunctival epithelium in a dry eye model.

A native-like corneal construct using donor corneal stroma for tissue engineering.

PROSE therapy used to minimize corneal trauma in patients with corneal epithelial defects.

Dry eye as a mucosal autoimmune disease.

Toll-like receptor expression and activation in mice with experimental dry eye.

Patient ocular conditions and clinical outcomes using a PROSE scleral device.

Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease under Experimental Murine Dry Eye.

Factors predicting the ocular surface response to desiccating environmental stress.

A novel interleukin 33/ST2 signaling regulates inflammatory response in human corneal epithelium.

Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial.

Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress.

T helper cytokines in dry eye disease.

In vivo confocal microscopy of the ocular surface: from bench to bedside.

Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease.

Tear meniscus dimensions in tear dysfunction and their correlation with clinical parameters.

Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye.

Atopic keratoconjunctivitis: A review.

Ocular surface disease and dacryoadenitis in aging C57BL/6 mice.

Effect of desiccating stress on mouse meibomian gland function.

A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells.

What causes dryness in Sjögren's syndrome patients and how can it be targeted?

New testing options for diagnosing and grading dry eye disease.

Human corneal epithelial cells produce antimicrobial peptides LL-37 and β-defensins in response to heat-killed Candida albicans.

Complications related to a cosmetic eye-whitening procedure.

Mucosal environmental sensors in the pathogenesis of dry eye.

Effect of loteprednol etabonate 0.5% on initiation of dry eye treatment with topical cyclosporine 0.05%.

Effects of L-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress.

Treatment of blepharitis: recent clinical trials.

Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-γ in experimental dry eye.

Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells.

Ocular drug delivery nanowafer with enhanced therapeutic efficacy.

Unique expression pattern and functional role of periostin in human limbal stem cells.

Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction.

Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease.

Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease.

Clinical guidelines for management of dry eye associated with Sjögren disease.

Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome.

Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells.

A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins.

IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells.

Dexamethasone nanowafer as an effective therapy for dry eye disease.

Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease.

Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas.

Corneal Sensitivity in Tear Dysfunction and its Correlation With Clinical Parameters and Blink Rate.

Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells.

Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model.

Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye.

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis--A Comprehensive Review and Guide to Therapy. I. Systemic Disease.

Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell Loss.

Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway.

Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye.

Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease.

Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease.

MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions.

Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome.

Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome.

Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model.

Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye.

Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis.

Interferon-gamma deficiency protects against aging-related goblet cell loss.

Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells.

Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation.

LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease.

Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye.

Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn.

Tear Volume-based Diagnostic Classification for Tear Dysfunction.

What We Have Learned From Animal Models of Dry Eye.

Long-term outcomes of ciliary sulcus versus capsular bag fixation of intraocular lenses in children: An ultrasound biomicroscopy study.

Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation.

Evolving risk factors and antibiotic sensitivity patterns for microbial keratitis at a large county hospital.

Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease.

Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human.

The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research.

Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice.

Goblet cell loss abrogates ocular surface immune tolerance.

Assessment of the Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) scleral lens on visual acuity for corneal irregularity and ocular surface disease.

Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice.

Near-infrared laser thermal conjunctivoplasty.

Protective role of commensal bacteria in Sjögren Syndrome.

Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast.

Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells.

Severity of Sjögren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells.

Bilateral Candida parapsilosis infiltration of nonhealing indolent epithelial defects in a diabetic patient with neurotrophic keratopathy.

Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome.

IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model.

Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells.

Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation.

Topical cyclosporine A therapy for dry eye syndrome.

Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial.

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide.

The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome.

Ocular complications of atopic dermatitis.

Immune - Goblet cell interaction in the conjunctiva.

Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions.

Regional Comparison of Goblet Cell Number and Area in Exposed and Covered Dry Eyes and Their Correlation with Tear MUC5AC.

IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation.

Biological functions of tear film.

Goblet cells promote tolerance induction in the conjunctiva.

Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye.

Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress.

The cornea in keratoconjunctivitis sicca.

Inflammatory basis for dry eye disease flares.

Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment.

Rapamycin Eyedrops Increased CD4Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface.

Autophagy Activation Protects Ocular Surface from Inflammation in a Dry Eye Model In Vitro.

Defining Dry Eye from a Clinical Perspective.

Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea.

Retinoid Regulation of Ocular Surface Innate Inflammation.

Conjunctivochalasis and Tear Osmolarity Are Associated With Reduced Conjunctival Epithelial Thickness in Dry Eye.

Video Viewing Blink Rate in Normal and Dry Eyes.

Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus.

Dry eye disease flares: A rapid evidence assessment.

Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis.

Differentially Expressed Gene Pathways in the Conjunctiva of Sjögren Syndrome Keratoconjunctivitis Sicca.

IL-36α/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress.

Combined therapy of ocular surface disease with plasma rich in growth factors and scleral contact lenses.

Gut-derived butyrate suppresses ocular surface inflammation.

Gut Microbiota From Sjögren syndrome Patients Causes Decreased T Regulatory Cells in the Lymphoid Organs and Desiccation-Induced Corneal Barrier Disruption in Mice.

Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes.

IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse.

Author Correction: Gut-derived butyrate suppresses ocular surface inflammation.

A multicenter report of the use of plasma rich in growth factors (PRGF) for the treatment of patients with ocular surface diseases in North America.

Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease.

Imbalanced IL-37/TNF-α/CTSS signaling disrupts corneal epithelial barrier in a dry eye model in vitro.

Quantitative assessment of botulinum toxin injection on blink rate in blepharospasm.

Delphi Panel Consensus Regarding Current Clinical Practice Management Options for .

Non-invasive and objective tear film breakup detection on interference color images using convolutional neural networks.

Clinical diagnosis and management of Demodex blepharitis: the Demodex Expert Panel on Treatment and Eyelid Health (DEPTH).

Comparison of Efficacy and Inflammatory Response to Thermoconjunctivoplasty Performed with Cautery or Pulsed 1460 nm Laser.

Dry eye disease and blinking behaviors: A narrative review of methodologies for measuring blink dynamics and inducing blink response.

Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca.