Weldon School of Biomedical Engineering
Craig Goergen is an Assistant Professor of Biomedical Engineering at Purdue University in West Lafayette, Indiana and the Principal Investigator of the Cardiovascular Imaging Research Laboratory. His work combines advanced engineering, imaging, and biological approaches to study a variety of cardiac and vascular diseases.
With funding from the NIH, NSF, AHA, and the Gates Foundation, Dr. Goergen and his team are working to improve cardiovascular disease diagnosis, treatment, and prevention, ultimately providing patients with longer and more fulfilling lives. Dr. Goergen received a BS degree in biomedical engineering from Washington University in St. Louis and MS and PhD degrees in bioengineering from Stanford University. In graduate school, Dr. Goergen worked with the Biomedical Imaging Group at Genentech to study abdominal aortic aneurysm formation. His postdoctoral training in molecular optical imaging at Harvard Medical School focused on cardiac disease and left ventricular remodeling.
Dr. Goergen joined the faculty at Purdue University in December of 2012 and was named the recipient of the 2017 Biomedical Engineering Society Rita Schaffer Young Investigator Award.
Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells.
Traffic (Copenhagen, Denmark) Dec, 2006 | Pubmed ID: 17052249
Effect of temperature on tether extraction, surface protrusion, and cortical tension of human neutrophils.
Biophysical journal Oct, 2007 | Pubmed ID: 17586566
Increased anterior abdominal aortic wall motion: possible role in aneurysm pathogenesis and design of endovascular devices.
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists Aug, 2007 | Pubmed ID: 17696635
In vivo quantification of murine aortic cyclic strain, motion, and curvature: implications for abdominal aortic aneurysm growth.
Journal of magnetic resonance imaging : JMRI Oct, 2010 | Pubmed ID: 20882615
Induced chromosome deletion in a Williams-Beuren syndrome mouse model causes cardiovascular abnormalities.
Journal of vascular research , 2011 | Pubmed ID: 20926892
Influences of aortic motion and curvature on vessel expansion in murine experimental aneurysms.
Arteriosclerosis, thrombosis, and vascular biology Feb, 2011 | Pubmed ID: 21071686
From molecules to myofibers: multiscale imaging of the myocardium.
Journal of cardiovascular translational research Aug, 2011 | Pubmed ID: 21643889
In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium.
Journal of biomedical optics May, 2012 | Pubmed ID: 22612124
Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance.
Angewandte Chemie (International ed. in English) Jul, 2012 | Pubmed ID: 22684680
Optical coherence tractography using intrinsic contrast.
Optics letters Sep, 2012 | Pubmed ID: 23041891
The PEG-fluorochrome shielding approach for targeted probe design.
Journal of the American Chemical Society Nov, 2012 | Pubmed ID: 23137147
Classification of coronary atherosclerotic plaques ex vivo with T1, T2, and ultrashort echo time CMR.
JACC. Cardiovascular imaging Apr, 2013 | Pubmed ID: 23498670
Molecular imaging of experimental abdominal aortic aneurysms.
TheScientificWorldJournal , 2013 | Pubmed ID: 23737735
Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement.
Annals of biomedical engineering Apr, 2015 | Pubmed ID: 25287646
Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement.
Annals of biomedical engineering Apr, 2015 | Pubmed ID: 25449148
Emerging trends in heart valve engineering: Part I. Solutions for future.
Annals of biomedical engineering Apr, 2015 | Pubmed ID: 25488074
Label-free in vivo imaging of peripheral nerve by multispectral photoacoustic tomography.
Journal of biophotonics Jan, 2016 | Pubmed ID: 25904317
Assessing breast tumor margin by multispectral photoacoustic tomography.
Biomedical optics express Apr, 2015 | Pubmed ID: 25909011
Imaging of small animal peripheral artery disease models: recent advancements and translational potential.
International journal of molecular sciences , 2015 | Pubmed ID: 25993289
Morphological and Biomechanical Differences in the Elastase and AngII apoE(-/-) Rodent Models of Abdominal Aortic Aneurysms.
BioMed research international , 2015 | Pubmed ID: 26064906
Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies.
Annals of biomedical engineering Oct, 2015 | Pubmed ID: 26224522
Comparison of Traditional and Integrated Digital Anesthetic Vaporizers.
Journal of the American Association for Laboratory Animal Science : JAALAS Nov, 2015 | Pubmed ID: 26632785
Chronically Elevated Levels of Short-Chain Fatty Acids Induce T Cell-Mediated Ureteritis and Hydronephrosis.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2016 | Pubmed ID: 26819206
Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves.
Photoacoustics Mar, 2016 | Pubmed ID: 27069873
Microstructural characterization of myocardial infarction with optical coherence tractography and two-photon microscopy.
Physiological reports 09, 2016 | Pubmed ID: 27650248
Murine ultrasound-guided transabdominal para-aortic injections of self-assembling type I collagen oligomers.
Journal of controlled release : official journal of the Controlled Release Society 03, 2017 | Pubmed ID: 28126527
Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice.
IEEE transactions on medical imaging 06, 2017 | Pubmed ID: 28186882
photoacoustic lipid imaging in mice using the second near-infrared window.
Biomedical optics express Feb, 2017 | Pubmed ID: 28270980
Development of a Glycosaminoglycan Derived, Selectin Targeting Anti-Adhesive Coating to Treat Endothelial Cell Dysfunction.
Pharmaceuticals (Basel, Switzerland) Mar, 2017 | Pubmed ID: 28353658
Oxygen nanobubbles revert hypoxia by methylation programming.
Scientific reports 08, 2017 | Pubmed ID: 28839175
Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy.
The Journal of biological chemistry 11, 2017 | Pubmed ID: 28916721
Substrate-based near-infrared imaging sensors enable fluorescence lifetime contrast via built-in dynamic fluorescence quenching elements.
ACS sensors Apr, 2016 | Pubmed ID: 28944290
Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats.
Journal of vascular research , 2018 | Pubmed ID: 29166645
Development and Validation of a Phase-Filtered Moving Ensemble Correlation for Echocardiographic Particle Image Velocimetry.
Ultrasound in medicine & biology 02, 2018 | Pubmed ID: 29195751
Cardiac and respiratory-gated volumetric murine ultrasound.
The international journal of cardiovascular imaging May, 2018 | Pubmed ID: 29234935
Multiscale and Spatially-Dependent Biomechanics Reveals Differential Strain Transfer Hierarchy in Skeletal Muscle.
ACS biomaterials science & engineering Nov, 2017 | Pubmed ID: 29276759
High-Frequency 4-Dimensional Ultrasound (4DUS): A Reliable Method for Assessing Murine Cardiac Function.
Tomography (Ann Arbor, Mich.) Dec, 2017 | Pubmed ID: 29308434
Three-dimensional visualization of extracellular matrix networks during murine development.
Developmental biology 03, 2018 | Pubmed ID: 29352963
Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy.
Scientific reports 02, 2018 | Pubmed ID: 29449656
Computational Fluid Dynamics of Vascular Disease in Animal Models.
Journal of biomechanical engineering 08, 2018 | Pubmed ID: 29570754
Development and growth trends in angiotensin II-induced murine dissecting abdominal aortic aneurysms.
Physiological reports 04, 2018 | Pubmed ID: 29696811
The Effect of Pentagalloyl Glucose on the Wall Mechanics and Inflammatory Activity of Rat Abdominal Aortic Aneurysms.
Journal of biomechanical engineering 08, 2018 | Pubmed ID: 30003259
Special Issue: Annual Education Issue Writing a Review Article for Publication as Part of a Graduate Engineering Course.
Journal of biomechanical engineering 08, 2018 | Pubmed ID: 30007030
Adjustable photoacoustic tomography probe improves light delivery and image quality.
Photoacoustics Dec, 2018 | Pubmed ID: 30175045
Regularization-Free Strain Mapping in Three Dimensions, With Application to Cardiac Ultrasound.
Journal of biomechanical engineering Jan, 2019 | Pubmed ID: 30267039
Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion.
Journal of magnetic resonance imaging : JMRI 01, 2019 | Pubmed ID: 30291650
Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics.
Annals of biomedical engineering Jan, 2019 | Pubmed ID: 30298373
After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.
Frontiers in cardiovascular medicine , 2019 | Pubmed ID: 30838213
Strain Mapping From Four-Dimensional Ultrasound Reveals Complex Remodeling in Dissecting Murine Abdominal Aortic Aneurysms.
Journal of biomechanical engineering Jun, 2019 | Pubmed ID: 30840030
Epithelial-mesenchymal Transition Phenotypes in Vertebral Metastases of Lung Cancer.
Toxicologic pathology 06, 2019 | Pubmed ID: 31064271
Early pathological characterization of murine dissecting abdominal aortic aneurysms.
APL bioengineering Dec, 2018 | Pubmed ID: 31069328
Simple minimally-invasive automatic antidote delivery device (A2D2) towards closed-loop reversal of opioid overdose.
Journal of controlled release : official journal of the Controlled Release Society 07, 2019 | Pubmed ID: 31158402
Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans.
Journal of vascular research , 2019 | Pubmed ID: 31272099
Biaxial biomechanical properties of the nonpregnant murine cervix and uterus.
Journal of biomechanics Jul, 2019 | Pubmed ID: 31353018
High-frequency murine ultrasound provides enhanced metrics of BAPN-induced AAA growth.
American journal of physiology. Heart and circulatory physiology 11, 2019 | Pubmed ID: 31559828
Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases.
Oncotarget Oct, 2019 | Pubmed ID: 31695842
Three-dimensional myocardial strain correlates with murine left ventricular remodelling severity post-infarction.
Journal of the Royal Society, Interface 11, 2019 | Pubmed ID: 31744418
Toward Automation of the Supine Pressor Test for Preeclampsia.
Journal of engineering and science in medical diagnostics and therapy Nov, 2019 | Pubmed ID: 32110775
B fibers are the best predictors of cardiac activity during Vagus nerve stimulation: Qing, vagal B fiber activation and cardiac effects.
Bioelectronic medicine , 2018 | Pubmed ID: 32232081
Label-free photoacoustic and ultrasound imaging for murine atherosclerosis characterization.
APL bioengineering Jun, 2020 | Pubmed ID: 32266325
Computational Hemodynamic Modeling of Arterial Aneurysms: A Mini-Review.
Frontiers in physiology , 2020 | Pubmed ID: 32477163
Recent Advances in Biomechanical Characterization of Thoracic Aortic Aneurysms.
Frontiers in cardiovascular medicine , 2020 | Pubmed ID: 32478096
Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection.
Scientific reports Jun, 2020 | Pubmed ID: 32514185
Integrated Image-Based Computational Fluid Dynamics Modeling Software as an Instructional Tool.
Journal of biomechanical engineering Nov, 2020 | Pubmed ID: 32529203
Evaluation of Hemodynamics in a Murine Hindlimb Ischemia Model Using Spatial Frequency Domain Imaging.
Lasers in surgery and medicine Apr, 2021 | Pubmed ID: 32956499
A Tumbling Magnetic Microrobot System for Biomedical Applications.
Micromachines Sep, 2020 | Pubmed ID: 32957563
Effects of Braiding Parameters on Tissue Engineered Vascular Graft Development.
Advanced healthcare materials 12, 2020 | Pubmed ID: 33063452
Heat therapy improves body composition and muscle function but does not affect capillary or collateral growth in a model of obesity and hindlimb ischemia.
Journal of applied physiology (Bethesda, Md. : 1985) Feb, 2021 | Pubmed ID: 33180645
Colour-Doppler echocardiography flow field velocity reconstruction using a streamfunction-vorticity formulation.
Journal of the Royal Society, Interface Dec, 2020 | Pubmed ID: 33259749
Preclinical techniques to investigate exercise training in vascular pathophysiology.
American journal of physiology. Heart and circulatory physiology Apr, 2021 | Pubmed ID: 33385323
Animal Model Dependent Response to Pentagalloyl Glucose in Murine Abdominal Aortic Injury.
Journal of clinical medicine Jan, 2021 | Pubmed ID: 33435461
Hemodynamic Assay of Hind Limb in Multiple Animal Models.
Military medicine Jan, 2021 | Pubmed ID: 33499513
Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs.
Scientific reports Feb, 2021 | Pubmed ID: 33526826
Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency.
Journal of lipid research , 2021 | Pubmed ID: 33757734
Improving characterization of hypertrophy-induced murine cardiac dysfunction using four-dimensional ultrasound-derived strain mapping.
American journal of physiology. Heart and circulatory physiology Jul, 2021 | Pubmed ID: 34085843
Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging.
Nature communications Jun, 2021 | Pubmed ID: 34140475
Machine Learning Driven Contouring of High-Frequency Four-Dimensional Cardiac Ultrasound Data.
Applied sciences (Basel, Switzerland) Feb, 2021 | Pubmed ID: 34306738
Strain Estimation of the Murine Right Ventricle Using High-Frequency Speckle-Tracking Ultrasound.
Ultrasound in medicine & biology Nov, 2021 | Pubmed ID: 34373135
Stable Thermally-Modulated Nanodroplet Ultrasound Contrast Agents.
Nanomaterials (Basel, Switzerland) Aug, 2021 | Pubmed ID: 34578541
Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery.
JVS-vascular science , 2021 | Pubmed ID: 34778850
Nuclear deformation guides chromatin reorganization in cardiac development and disease.
Nature biomedical engineering Dec, 2021 | Pubmed ID: 34857921
Detection and Monitoring of Viral Infections via Wearable Devices and Biometric Data.
Annual review of biomedical engineering Jun, 2022 | Pubmed ID: 34932906
Quantification of murine myocardial infarct size using 2-D and 4-D high-frequency ultrasound.
American journal of physiology. Heart and circulatory physiology 03, 2022 | Pubmed ID: 34995167
Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition.
Scientific reports Jan, 2022 | Pubmed ID: 34997075
A Wireless Implantable Strain Sensing Scheme Using Ultrasound Imaging of Highly Stretchable Zinc Oxide/Poly Dimethylacrylamide Nanocomposite Hydrogel.
ACS applied bio materials Jul, 2020 | Pubmed ID: 35025476
Assessment of photoacoustic tomography contrast for breast tissue imaging using 3D correlative virtual histology.
Scientific reports Feb, 2022 | Pubmed ID: 35169198
Navigating the Regulatory Pathway for Medical Devices-a Conversation with the FDA, Clinicians, Researchers, and Industry Experts.
Journal of cardiovascular translational research Oct, 2022 | Pubmed ID: 35288821
Myocardial strain imaging in Duchenne muscular dystrophy.
Frontiers in cardiovascular medicine , 2022 | Pubmed ID: 36505382
Neurovascular hypoxia after mild traumatic brain injury in juvenile mice correlates with heart-brain dysfunctions in adulthood.
Acta physiologica (Oxford, England) Jun, 2023 | Pubmed ID: 36625322
Clinical Immersion of Undergraduate Biomedical Engineering Students: Best Practices for Short-Term Programs.
Biomedical engineering education Feb, 2023 | Pubmed ID: 36778754
Localized strain characterization of cardiomyopathy in Duchenne muscular dystrophy using novel 4D kinematic analysis of cine cardiovascular magnetic resonance.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance Feb, 2023 | Pubmed ID: 36793101
Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves.
Cell & bioscience Mar, 2023 | Pubmed ID: 36864465
Application of 4-D ultrasound-derived regional strain and proteomics analysis in -deficient male mice.
American journal of physiology. Heart and circulatory physiology Aug, 2023 | Pubmed ID: 37326999
Early Changes in Porcine Larynges Following Injection of Motor-Endplate Expressing Muscle Cells for the Treatment of Unilateral Vocal Fold Paralysis.
The Laryngoscope Jan, 2024 | Pubmed ID: 37436167
Simulating Subject-Specific Aortic Hemodynamic Effects of Valvular Lesions in Rheumatic Heart Disease.
Journal of biomechanical engineering Nov, 2023 | Pubmed ID: 37470483
In Vivo Visualization and Quantification of Rat Laryngeal Blood Supply After Hydration Challenge.
The Laryngoscope Feb, 2024 | Pubmed ID: 37584333
Biomechanical characterization of tissue types in murine dissecting aneurysms based on histology and 4D ultrasound-derived strain.
Biomechanics and modeling in mechanobiology Oct, 2023 | Pubmed ID: 37707685
PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation.
Circulation research Oct, 2023 | Pubmed ID: 37737016
Longitudinal investigation of aortic dissection in mice with computational fluid dynamics.
Computer methods in biomechanics and biomedical engineering Nov, 2024 | Pubmed ID: 37897230
Regional 4D Cardiac Magnetic Resonance Strain Predicts Cardiomyopathy Progression in Duchenne Muscular Dystrophy.
medRxiv : the preprint server for health sciences Nov, 2023 | Pubmed ID: 37986975
Aortic dissection detection and thrombus structure quantification using volumetric ultrasound, histology, and scanning electron microscopy.
JVS-vascular science , 2023 | Pubmed ID: 38077164
Investigation of direction- and age-dependent prestretch in mouse cranial dura mater.
Biomechanics and modeling in mechanobiology Jun, 2024 | Pubmed ID: 38206531
Patellar tendon biomechanical and morphologic properties and their relationship to serum clinical variables in persons with prediabetes and type 2 diabetes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Aug, 2024 | Pubmed ID: 38400550
Photocurable extracellular matrix sealant for cessation of venous hemorrhage.
Journal of biomedical materials research. Part B, Applied biomaterials Apr, 2024 | Pubmed ID: 38520703
Greater Protein Intake Emphasizing Lean Beef Does Not Affect Resistance Training-Induced Adaptations in Skeletal Muscle and Tendon of Older Women: A Randomized Controlled Feeding Trial.
The Journal of nutrition Jun, 2024 | Pubmed ID: 38604504
Functional cardiac consequences of β-adrenergic stress-induced injury in the mouse model of Duchenne muscular dystrophy.
bioRxiv : the preprint server for biology Apr, 2024 | Pubmed ID: 38659739
Automatic Segmentation for Analysis of Murine Cardiac Ultrasound and Photoacoustic Image Data Using Deep Learning.
Ultrasound in medicine & biology Aug, 2024 | Pubmed ID: 38825556
Impact of maternal posture on fetal physiology in human pregnancy: a narrative review.
Frontiers in physiology , 2024 | Pubmed ID: 38827993
In Vivo Three-Dimensional Geometric Reconstruction of the Mouse Aortic Heart Valve.
Annals of biomedical engineering Sep, 2024 | Pubmed ID: 38874705
4D ultrasound-based strain assessment of cardiac dysfunction in male rats with reperfused and nonreperfused myocardial infarction.
Physiological reports Jul, 2024 | Pubmed ID: 39039717
Maternal posture-physiology interactions in human pregnancy: a narrative review.
Frontiers in physiology , 2024 | Pubmed ID: 39100275
Deep learning enables accurate soft tissue tendon deformation estimation in vivo via ultrasound imaging.
Scientific reports Aug, 2024 | Pubmed ID: 39117664
Functional cardiac consequences of β-adrenergic stress-induced injury in a model of Duchenne muscular dystrophy.
Disease models & mechanisms Oct, 2024 | Pubmed ID: 39268580
A Novel Echocardiography Feature-Tracking Algorithm for Stabilized Frame-to-Frame Extraction of Aortic Root Diameters in the Parasternal Long Axis.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Jan, 2025 | Pubmed ID: 39299353
Physics-Informed Graph Neural Networks to solve 1-D equations of blood flow.
Computer methods and programs in biomedicine Dec, 2024 | Pubmed ID: 39326359
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