Thomas S. Griffith

Department of Urology, University of Minnesota

Research Area

Cancer Research

Biography

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title	2023
Publication title	2023
Publication title	2023
Publication title	2023
Publication title	2017

Other Publications

Article	Year
Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12023355	2002
Induction and regulation of tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand-mediated apoptosis in renal cell carcinoma. Cancer research\| PubMed ID: 12036919	2002
TRAIL: a mechanism of tumor surveillance in an immune privileged site. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12391182	2002
Cell death and immune privilege. International reviews of immunology\| PubMed ID: 12424841	2002
Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand. Cancer research\| PubMed ID: 12499252	2002
Apoptosis, tolerance, and regulatory T cells--old wine, new wineskins. Immunological reviews\| PubMed ID: 12752676	2003
The topoisomerase I inhibitor topotecan increases the sensitivity of prostate tumor cells to TRAIL/Apo-2L-induced apoptosis. Cancer chemotherapy and pharmacology\| PubMed ID: 12811515	2003
Plasmacytoid dendritic cell-derived IFN-alpha induces TNF-related apoptosis-inducing ligand/Apo-2L-mediated antitumor activity by human monocytes following CpG oligodeoxynucleotide stimulati... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12817000	2003
Structure/function analysis of the murine CD95L promoter reveals the identification of a novel transcriptional repressor and functional CD28 response element. The Journal of biological chemistry\| PubMed ID: 12855690	2003
Tumor necrosis factor-related apoptosis-inducing ligand: a novel mechanism for Bacillus Calmette-Guérin-induced antitumor activity. Cancer research\| PubMed ID: 15150089	2004
Human B cells express functional TRAIL/Apo-2 ligand after CpG-containing oligodeoxynucleotide stimulation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15240676	2004
Inhibition of the NF-kappaB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells. Cancer gene therapy\| PubMed ID: 15332116	2004
Expression of TNF-related apoptosis-inducing ligand (TRAIL) in megakaryocytes and platelets. Experimental hematology\| PubMed ID: 15539085	2004
Immunostimulatory oligodeoxynucleotides induce apoptosis of B cell chronic lymphocytic leukemia cells. Journal of leukocyte biology\| PubMed ID: 15582984	2005
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature\| PubMed ID: 15744305	2005
Depsipeptide (FR901228) enhances the cytotoxic activity of TRAIL by redistributing TRAIL receptor to membrane lipid rafts. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15771957	2005
Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2L. Blood\| PubMed ID: 16037389	2005
Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression. Cancer biology & therapy\| PubMed ID: 16096370	2005
Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells. Cancer research\| PubMed ID: 16397266	2006
Neisseria gonorrhoeae delays the onset of apoptosis in polymorphonuclear leukocytes. Cellular microbiology\| PubMed ID: 16803582	2006
TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16818756	2006
Survivin inhibits apoptosis induced by TRAIL, and the ratio between survivin and TRAIL receptors is predictive of recurrent disease in neuroblastoma. Journal of pediatric surgery\| PubMed ID: 16863850	2006
A vision of cell death: Fas ligand and immune privilege 10 years later. Immunological reviews\| PubMed ID: 16972907	2006
Induction of protective immunity to RM-1 prostate cancer cells with ALVAC-IL-2/IL-12/TNF-alpha combination therapy. International journal of cancer\| PubMed ID: 16991124	2006
Identification of the mycobacterial subcomponents involved in the release of tumor necrosis factor-related apoptosis-inducing ligand from human neutrophils. Infection and immunity\| PubMed ID: 17194806	2007
Histone deacetylase inhibitors enhance Ad5-TRAIL killing of TRAIL-resistant prostate tumor cells through increased caspase-2 activity. Apoptosis : an international journal on programmed cell death\| PubMed ID: 17195089	2007
The role of Fas ligand and TNF-related apoptosis-inducing ligand (TRAIL) in the ocular immune response. Chemical immunology and allergy\| PubMed ID: 17264490	2007
Apoptotic cells induce tolerance by generating helpless CD8+ T cells that produce TRAIL. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17312109	2007
TRAIL death receptor-4 expression positively correlates with the tumor grade in breast cancer patients with invasive ductal carcinoma. International journal of radiation oncology, biology, physics\| PubMed ID: 17512128	2007
Neutrophils and TRAIL: insights into BCG immunotherapy for bladder cancer. Immunologic research\| PubMed ID: 17917057	2007
Predicting bacillus Calmette-Guerin immunotherapy effectiveness. The Journal of urology\| PubMed ID: 17936825	2007
Cytomegalovirus and the role of interferon in the expression of tumor necrosis factor-related apoptosis-inducing ligand in the placenta. American journal of obstetrics and gynecology\| PubMed ID: 18060949	2007
TNF-related apoptosis-inducing ligand (TRAIL) is expressed throughout myeloid development, resulting in a broad distribution among neutrophil granules. Journal of leukocyte biology\| PubMed ID: 18063697	2008
Activation of tumor-specific CD8+ T Cells after intratumoral Ad5-TRAIL/CpG oligodeoxynucleotide combination therapy. Cancer research\| PubMed ID: 18089829	2007
Molecular mechanisms of death ligand-mediated immune modulation: a gene therapy model to prolong islet survival in type 1 diabetes. Journal of cellular biochemistry\| PubMed ID: 18247339	2008
Tumor necrosis factor-related apoptosis inducing ligand-R4 decoy receptor expression is correlated with high Gleason scores, prostate-specific antigen recurrence, and decreased survival in p... Urologic oncology\| PubMed ID: 18312935	2008
High levels of endogenous tumor necrosis factor-related apoptosis-inducing ligand expression correlate with increased cell death in human pancreas. Pancreas\| PubMed ID: 18437085	2008
Role of neutrophils in BCG immunotherapy for bladder cancer. Urologic oncology\| PubMed ID: 18593617	2008
Influenza-induced expression of functional tumor necrosis factor-related apoptosis-inducing ligand on human peripheral blood mononuclear cells. Human immunology\| PubMed ID: 18723061	2008
CD8 T cells utilize TRAIL to control influenza virus infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18802095	2008
High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients. Pancreas\| PubMed ID: 18981952	2009
The use of immunofluorescence in microdissection testicular sperm extraction. Journal of andrology\| PubMed ID: 19234316	2009
TRAIL gene therapy: from preclinical development to clinical application. Current gene therapy\| PubMed ID: 19275567	2009
Early microrecanalization of vas deferens following biodegradable graft implantation in bilaterally vasectomized rats. Asian journal of andrology\| PubMed ID: 19349949	2009
[Not Available]. Journal of oncology\| PubMed ID: 19547714	2009
Induction of tumor cell apoptosis by TRAIL gene therapy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19565910	2009
Adenovirus-mediated TRAIL gene (Ad5hTRAIL) delivery into pancreatic islets prolongs normoglycemia in streptozotocin-induced diabetic rats. Human gene therapy\| PubMed ID: 19572802	2009
In vivo fluorescence imaging is well-suited for the monitoring of adenovirus directed transgene expression in living organisms. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 19789926	2010
TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies. European journal of pharmacology\| PubMed ID: 19836385	2009
Activation-induced CD154 expression abrogates tolerance induced by apoptotic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19841180	2009
TRAIL-deficient mice exhibit delayed regression of retinal neovascularization. The American journal of pathology\| PubMed ID: 19893042	2009
The role of neutrophils and TNF-related apoptosis-inducing ligand (TRAIL) in bacillus Calmette-Guérin (BCG) immunotherapy for urothelial carcinoma of the bladder. Cancer metastasis reviews\| PubMed ID: 19967427	2009
Bacillus Calmette-Guerin immunotherapy for urothelial carcinoma of the bladder. Immunotherapy\| PubMed ID: 20046960	2009
Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20483771	2010
Conatumumab, a fully human mAb against death receptor 5 for the treatment of cancer. Current opinion in investigational drugs (London, England : 2000)\| PubMed ID: 20496264	2010
Micro-recanalization in a biodegradable graft for reconstruction of the vas deferens is enhanced by sildenafil citrate. Asian journal of andrology\| PubMed ID: 20639908	2010
Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist. Apoptosis : an international journal on programmed cell death\| PubMed ID: 20734142	2011
TRAIL-expressing CD8+ T cells mediate tolerance following soluble peptide-induced peripheral T cell deletion. Journal of leukocyte biology\| PubMed ID: 20807702	2010
NF-κB targeting by way of IKK inhibition sensitizes lung cancer cells to adenovirus delivery of TRAIL. BMC cancer\| PubMed ID: 20977779	2010
Systemic immunological tolerance to ocular antigens is mediated by TRAIL-expressing CD8+ T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21169546	2011
Tracing of islet graft survival by way of in vivo fluorescence imaging. Diabetes/metabolism research and reviews\| PubMed ID: 21584921	2011
Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21788440	2011
Description of a novel murine model for ileocystoplasty and early histologic changes. TheScientificWorldJournal\| PubMed ID: 21789468	2011
Clinical significance of TRAIL and TRAIL receptors in patients with head and neck cancer. Head & neck\| PubMed ID: 21837697	2011
The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21940678	2011
The plasticity of regulatory T cell function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22013112	2011
Cell death in the maintenance and abrogation of tolerance: the five Ws of dying cells. Immunity\| PubMed ID: 22035838	2011
Effect of Combined Locally Delivered Growth Factors and Systemic Sildenafil Citrate on Microrecanalization in Biodegradable Conduit for Vas Deferens Reconstruction. Urology\| PubMed ID: 22285175	2012
Eradication of metastatic renal cell carcinoma after adenovirus-encoded TNF-related apoptosis-inducing ligand (TRAIL)/CpG immunotherapy. PloS one\| PubMed ID: 22312440	2012
Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22745381	2012
Therapeutic potential of VIP vs PACAP in diabetes. Journal of molecular endocrinology\| PubMed ID: 22991228	2012
Insulin gene therapy from design to beta cell generation. Expert reviews in molecular medicine\| PubMed ID: 23062285	2012
TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice. The Journal of experimental medicine\| PubMed ID: 23071253	2012
Activation of systemic antitumor immunity via TRAIL-induced apoptosis. Oncoimmunology\| PubMed ID: 23170271	2012
Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23355736	2013
PMN and anti-tumor immunity--the case of bladder cancer immunotherapy. Seminars in cancer biology\| PubMed ID: 23410637	2013
T-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppression. Critical reviews in immunology\| PubMed ID: 23510024	2013
Clinical utility of insulin and insulin analogs. Islets\| PubMed ID: 23584214	2013
Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer. Cancers\| PubMed ID: 24212631	2011
Intravascular staining for discrimination of vascular and tissue leukocytes. Nature protocols\| PubMed ID: 24385150	2014
Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival. Cell host & microbe\| PubMed ID: 24439895	2014
Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24646738	2014
GLP-1-mediated gene therapy approaches for diabetes treatment. Expert reviews in molecular medicine\| PubMed ID: 24666581	2014
Effective TRAIL-based immunotherapy requires both plasmacytoid and CD8α dendritic cells. Cancer immunology, immunotherapy : CII\| PubMed ID: 24711083	2014
Minimal changes in the systemic immune response after nephrectomy of localized renal masses. Urologic oncology\| PubMed ID: 24768357	2014
Impact of sepsis on CD4 T cell immunity. Journal of leukocyte biology\| PubMed ID: 24791959	2014
CpG-mediated modulation of MDSC contributes to the efficacy of Ad5-TRAIL therapy against renal cell carcinoma. Cancer immunology, immunotherapy : CII\| PubMed ID: 25143233	2014
Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function. PloS one\| PubMed ID: 25541945	2014
Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25595784	2015
The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25972483	2015
Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25980007	2015
Exploiting natural anti-tumor immunity for metastatic renal cell carcinoma. Human vaccines & immunotherapeutics\| PubMed ID: 25996049	2015
Therapeutic applications of TRAIL receptor agonists in cancer and beyond. Pharmacology & therapeutics\| PubMed ID: 26343199	2015
Triptolide enhances the tumoricidal activity of TRAIL against renal cell carcinoma. The FEBS journal\| PubMed ID: 26426449	2015
Gut Microbial Membership Modulates CD4 T Cell Reconstitution and Function after Sepsis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27448587	2016
CD8 T Cell-Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas. Cancers\| PubMed ID: 27472363	2016
Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity. Critical reviews in immunology\| PubMed ID: 27480902	2016
Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 27633573	2017
Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27798171	2016
Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice. Cell death & disease\| PubMed ID: 28055006	2017