William C. Mobley

Department of Neuroscience, University of California at San Diego

Affiliated withUniversity of California at San Diego University of California, San Diego

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2014
Publication title	2014

Other Publications

Article	Year
Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends in neurosciences\| PubMed ID: 12536130	2003
NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron\| PubMed ID: 12848933	2003
Trafficking the NGF signal: implications for normal and degenerating neurons. Progress in brain research\| PubMed ID: 14699953	2004
Signaling endosome hypothesis: A cellular mechanism for long distance communication. Journal of neurobiology\| PubMed ID: 14704953	2004
Going the distance, or not, with neurotrophin signals. Cell\| PubMed ID: 15260984	2004
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15371516	2004
Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation. Brain research\| PubMed ID: 15374749	2004
An AUPN/ANA survey of department leader opinions on the health of US academic neurology. Neurology\| PubMed ID: 15505148	2004
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. The Journal of comparative neurology\| PubMed ID: 15515178	2004
Long-distance retrograde neurotrophic signaling. Current opinion in neurobiology\| PubMed ID: 15721743	2005
Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 15859352	2005
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16801538	2006
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron\| PubMed ID: 16815330	2006
Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17287360	2007
Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. The Journal of comparative neurology\| PubMed ID: 17663443	2007
One at a time, live tracking of NGF axonal transport using quantum dots. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17698956	2007
A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic (Copenhagen, Denmark)\| PubMed ID: 17822405	2007
Using mouse models to explore genotype-phenotype relationship in Down syndrome. Mental retardation and developmental disabilities research reviews\| PubMed ID: 17910089	2007
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic (Copenhagen, Denmark)\| PubMed ID: 18034774	2008
Sleep and EEG features in genetic models of Down syndrome. Neurobiology of disease\| PubMed ID: 18282758	2008
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. The Journal of comparative neurology\| PubMed ID: 18306326	2008
Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Critical reviews in toxicology\| PubMed ID: 18726789	2008
Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18768694	2008
The coming of age of axonal neurotrophin signaling endosomes. Journal of proteomics\| PubMed ID: 19028611	2009
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. The Journal of comparative neurology\| PubMed ID: 19034952	2009
Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation. Neurobiology of disease\| PubMed ID: 19167498	2009
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. The Journal of comparative neurology\| PubMed ID: 19296534	2009
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19420260	2009
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genetics in medicine : official journal of the American College of Medical Genetics\| PubMed ID: 19636252	2009
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 20512340	2010
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron\| PubMed ID: 20826309	2010
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain research\| PubMed ID: 20932954	2010
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. Journal of neurochemistry\| PubMed ID: 21388375	2011
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiology of disease\| PubMed ID: 21527343	2011
Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator. Organic letters\| PubMed ID: 21812392	2011
Mouse models for Down syndrome-associated developmental cognitive disabilities. Developmental neuroscience\| PubMed ID: 21865664	2011
Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiology of disease\| PubMed ID: 22062771	2012
Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioengineered bugs\| PubMed ID: 22126738	2012
Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Current opinion in neurobiology\| PubMed ID: 22658745	2012
Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22764230	2012
Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Archives of neurology\| PubMed ID: 22801784	2012
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature medicine\| PubMed ID: 23524343	2013
Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 23526661	2013
Aging and intellectual disability: Insights from mouse models of down syndrome. Developmental disabilities research reviews\| PubMed ID: 23949828	2013
Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Human molecular genetics\| PubMed ID: 24041763	2014
The challenge of connecting the dots in the B.R.a.I.N. Neuron\| PubMed ID: 24139032	2013
Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species. Biochemistry\| PubMed ID: 24401146	2014