Wah Chiu

National Center for Macromolecular Imaging, Baylor College of Medicine

Affiliated withBaylor College of Medicine

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2014

Other Publications

Article	Year
Quaternary structure of human fatty acid synthase by electron cryomicroscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11756679	2002
Bilamellar cationic liposomes protect adenovectors from preexisting humoral immune responses. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 11863412	2002
High resolution structural studies of complex icosahedral viruses: a brief overview. Virus research\| PubMed ID: 11885957	2002
Electron cryo-microscopy of VAT, the archaeal p97/CDC48 homologue from Thermoplasma acidophilum. Journal of molecular biology\| PubMed ID: 11955016	2002
Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics approaches. Current opinion in structural biology\| PubMed ID: 11959506	2002
The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12218169	2002
Structure of isolated nucleocapsids from venezuelan equine encephalitis virus and implications for assembly and disassembly of enveloped virus. Journal of virology\| PubMed ID: 12477868	2003
Coat protein fold and maturation transition of bacteriophage P22 seen at subnanometer resolutions. Nature structural biology\| PubMed ID: 12536205	2003
Mitochondrial ATP synthasome. Cristae-enriched membranes and a multiwell detergent screening assay yield dispersed single complexes containing the ATP synthase and carriers for Pi and ADP/AT... The Journal of biological chemistry\| PubMed ID: 12560333	2003
Structure of the herpesvirus major capsid protein. The EMBO journal\| PubMed ID: 12574112	2003
Web-based Simulation for Contrast Transfer Function and Envelope Functions. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada\| PubMed ID: 12597807	2001
Structure of the type 1 inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy. The Journal of biological chemistry\| PubMed ID: 12714606	2003
Multislice computed tomography angiography in pediatric liver transplantation. Transplantation\| PubMed ID: 12883192	2003
Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics. Journal of molecular biology\| PubMed ID: 12888351	2003
Virus structure. Preface. Advances in protein chemistry\| PubMed ID: 13677043	2003
Determination of icosahedral virus structures by electron cryomicroscopy at subnanometer resolution. Advances in protein chemistry\| PubMed ID: 13677046	2003
Studying large viruses. Advances in protein chemistry\| PubMed ID: 13677054	2003
The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell\| PubMed ID: 14567920	2003
Focal pair merging for contrast enhancement of single particles. Journal of structural biology\| PubMed ID: 14643210	2003
Applications of a bilateral denoising filter in biological electron microscopy. Journal of structural biology\| PubMed ID: 14643214	2003
Structure of triglyceride-rich human low-density lipoproteins according to cryoelectron microscopy. Biochemistry\| PubMed ID: 14674775	2003
Object oriented database and electronic notebook for transmission electron microscopy. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada\| PubMed ID: 14750990	2003
Electron beam coater for reduction of charging in ice-embedded biological specimens using Ti(88)Si(12) alloy. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada\| PubMed ID: 14750991	2003
Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis. Structure (London, England : 1993)\| PubMed ID: 14962379	2004
Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP. The Journal of biological chemistry\| PubMed ID: 15166242	2004
A 9 angstroms single particle reconstruction from CCD captured images on a 200 kV electron cryomicroscope. Journal of structural biology\| PubMed ID: 15193640	2004
Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane... Virology\| PubMed ID: 15207623	2004
SARS in newborns and children. Biology of the neonate\| PubMed ID: 15218286	2004
Seeing GroEL at 6 A resolution by single particle electron cryomicroscopy. Structure (London, England : 1993)\| PubMed ID: 15242589	2004
Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer. The EMBO journal\| PubMed ID: 15272307	2004
Structure of the acrosomal bundle. Nature\| PubMed ID: 15343340	2004
Structure of Ca2+ release channel at 14 A resolution. Journal of molecular biology\| PubMed ID: 15581887	2005
Structural characterization of components of protein assemblies by comparative modeling and electron cryo-microscopy. Journal of structural biology\| PubMed ID: 15681235	2005
Electron cryomicroscopy of biological machines at subnanometer resolution. Structure (London, England : 1993)\| PubMed ID: 15766537	2005
The pore structure of the closed RyR1 channel. Structure (London, England : 1993)\| PubMed ID: 16084392	2005
A digital atlas to characterize the mouse brain transcriptome. PLoS computational biology\| PubMed ID: 16184189	2005
Fast rotational matching of single-particle images. Journal of structural biology\| PubMed ID: 16236526	2005
Common ancestry of herpesviruses and tailed DNA bacteriophages. Journal of virology\| PubMed ID: 16282496	2005
Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. Molecular cell\| PubMed ID: 16364911	2005
Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus. Nature\| PubMed ID: 16452981	2006
Structural biology of cellular machines. Trends in cell biology\| PubMed ID: 16459078	2006
Refinement of protein structures by iterative comparative modeling and CryoEM density fitting. Journal of molecular biology\| PubMed ID: 16490207	2006
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nature structural & molecular biology\| PubMed ID: 16491093	2006
3D volume reconstruction of a mouse brain from histological sections using warp filtering. Journal of neuroscience methods\| PubMed ID: 16580732	2006
Hybrid segmentation framework for tissue images containing gene expression data. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention\| PubMed ID: 16685853	2005
Cryo-EM asymmetric reconstruction of bacteriophage P22 reveals organization of its DNA packaging and infecting machinery. Structure (London, England : 1993)\| PubMed ID: 16730179	2006
Automated segmentation of molecular subunits in electron cryomicroscopy density maps. Journal of structural biology\| PubMed ID: 16908194	2006
Outcome of a workshop on archiving structural models of biological macromolecules. Structure (London, England : 1993)\| PubMed ID: 16955948	2006
Cryoelectron microscopy of protein IX-modified adenoviruses suggests a new position for the C terminus of protein IX. Journal of virology\| PubMed ID: 16987967	2006
Structure of Halothiobacillus neapolitanus carboxysomes by cryo-electron tomography. Journal of molecular biology\| PubMed ID: 17028023	2006
Assessing the capabilities of a 4kx4k CCD camera for electron cryo-microscopy at 300kV. Journal of structural biology\| PubMed ID: 17067819	2006
Ab initio modeling of the herpesvirus VP26 core domain assessed by CryoEM density. PLoS computational biology\| PubMed ID: 17069457	2006
An expanded conformation of single-ring GroEL-GroES complex encapsulates an 86 kDa substrate. Structure (London, England : 1993)\| PubMed ID: 17098196	2006
Electron cryotomography reveals the portal in the herpesvirus capsid. Journal of virology\| PubMed ID: 17151101	2007
Identification of secondary structure elements in intermediate-resolution density maps. Structure (London, England : 1993)\| PubMed ID: 17223528	2007
Single-particle electron cryomicroscopy of the ion channels in the excitation-contraction coupling junction. Methods in cell biology\| PubMed ID: 17327167	2007
Genome sequence, structural proteins, and capsid organization of the cyanophage Syn5: a "horned" bacteriophage of marine synechococcus. Journal of molecular biology\| PubMed ID: 17383677	2007
DNA packaging and delivery machines in tailed bacteriophages. Current opinion in structural biology\| PubMed ID: 17395453	2007
Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins. Nature structural & molecular biology\| PubMed ID: 17460696	2007
Learning-based segmentation framework for tissue images containing gene expression data. IEEE transactions on medical imaging\| PubMed ID: 17518066	2007
Cryoelectron microscopy of icosahedral virus particles. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 17656759	2007
Averaging tens to hundreds of icosahedral particle images to resolve protein secondary structure elements using a Multi-Path Simulated Annealing optimization algorithm. Journal of structural biology\| PubMed ID: 17698370	2007
Biophysical methods: structure, dynamics and gorgeous images. Current opinion in structural biology\| PubMed ID: 17959374	2007
Crystallographic conformers of actin in a biologically active bundle of filaments. Journal of molecular biology\| PubMed ID: 18022194	2008
Modular software platform for low-dose electron microscopy and tomography. Journal of microscopy\| PubMed ID: 18045333	2007
Protein structure fitting and refinement guided by cryo-EM density. Structure (London, England : 1993)\| PubMed ID: 18275820	2008
Backbone structure of the infectious epsilon15 virus capsid revealed by electron cryomicroscopy. Nature\| PubMed ID: 18305544	2008
De novo backbone trace of GroEL from single particle electron cryomicroscopy. Structure (London, England : 1993)\| PubMed ID: 18334219	2008
Computing a family of skeletons of volumetric models for shape description. Computer aided design\| PubMed ID: 18449328	2007
Achievable resolution from images of biological specimens acquired from a 4k x 4k CCD camera in a 300-kV electron cryomicroscope. Journal of structural biology\| PubMed ID: 18514542	2008
Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. Nature structural & molecular biology\| PubMed ID: 18536725	2008
Remotely triggered liposome release by near-infrared light absorption via hollow gold nanoshells. Journal of the American Chemical Society\| PubMed ID: 18543914	2008
Location and flexibility of the unique C-terminal tail of Aquifex aeolicus co-chaperonin protein 10 as derived by cryo-electron microscopy and biophysical techniques. Journal of molecular biology\| PubMed ID: 18588898	2008
Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18621707	2008
JADAS: a customizable automated data acquisition system and its application to ice-embedded single particles. Journal of structural biology\| PubMed ID: 18926912	2009
Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19264960	2009
Structural mechanism of SDS-induced enzyme activity of scorpion hemocyanin revealed by electron cryomicroscopy. Structure (London, England : 1993)\| PubMed ID: 19446530	2009
Refinement of protein structures into low-resolution density maps using rosetta. Journal of molecular biology\| PubMed ID: 19596339	2009
Automated pipeline for atlas-based annotation of gene expression patterns: application to postnatal day 7 mouse brain. Methods (San Diego, Calif.)\| PubMed ID: 19698790	2010
Radiation damage effects at four specimen temperatures from 4 to 100 K. Journal of structural biology\| PubMed ID: 19903530	2010
Model of human low-density lipoprotein and bound receptor based on cryoEM. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080547	2010
Mechanism of folding chamber closure in a group II chaperonin. Nature\| PubMed ID: 20090755	2010
4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20194787	2010
Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions. Journal of structural biology\| PubMed ID: 20338243	2010
Automated specimen search in cryo-TEM observation with DIFF-defocus imaging. Journal of electron microscopy\| PubMed ID: 20356853	2010
Tracing conformational changes in proteins. BMC structural biology\| PubMed ID: 20487508	2010
MOTIF-EM: an automated computational tool for identifying conserved regions in CryoEM structures. Bioinformatics (Oxford, England)\| PubMed ID: 20529921	2010
Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus. Nature structural & molecular biology\| PubMed ID: 20543830	2010
Identifying Components in 3D Density Maps of Protein Nanomachines by Multi-scale Segmentation. IEEE/NIH Life Science Systems and Applications Workshop. IEEE/NIH Life Science Systems and Applications Workshop\| PubMed ID: 20556220	2009
A geometric database for gene expression data. Symposium on geometry processing : [proceedings] / sponsored by the Eurographics Association in cooperation with ACM SIGGRAPH. Symposium on Geometry Processing\| PubMed ID: 20631855	2003
Zernike phase contrast cryo-electron microscopy and tomography for structure determination at nanometer and subnanometer resolutions. Structure (London, England : 1993)\| PubMed ID: 20696391	2010
Visualizing the structural changes of bacteriophage Epsilon15 and its Salmonella host during infection. Journal of molecular biology\| PubMed ID: 20709082	2010
Cryo-EM of macromolecular assemblies at near-atomic resolution. Nature protocols\| PubMed ID: 20885381	2010
Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography. Journal of molecular biology\| PubMed ID: 20933521	2010
EMDataBank.org: unified data resource for CryoEM. Nucleic acids research\| PubMed ID: 20935055	2011
Workshop on molecular animation. Structure (London, England : 1993)\| PubMed ID: 20947014	2010
The group II chaperonin Mm-Cpn binds and refolds human γD crystallin. Protein science : a publication of the Protein Society\| PubMed ID: 20981710	2011
Discrete structure of an RNA folding intermediate revealed by cryo-electron microscopy. Journal of the American Chemical Society\| PubMed ID: 21038867	2010
Workshop on the validation and modeling of electron cryo-microscopy structures of biological nanomachines. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing\| PubMed ID: 21121065	2011
Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21220301	2011
Dual action of ATP hydrolysis couples lid closure to substrate release into the group II chaperonin chamber. Cell\| PubMed ID: 21241893	2011
Modeling protein structure at near atomic resolutions with Gorgon. Journal of structural biology\| PubMed ID: 21296162	2011
Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nature materials\| PubMed ID: 21336265	2011
Partially polymerized liposomes: stable against leakage yet capable of instantaneous release for remote controlled drug delivery. Nanotechnology\| PubMed ID: 21389566	2011
Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure. Structure (London, England : 1993)\| PubMed ID: 21565698	2011
Practical performance evaluation of a 10k × 10k CCD for electron cryo-microscopy. Journal of structural biology\| PubMed ID: 21619932	2011
Structure of Trypanosoma brucei flagellum accounts for its bihelical motion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21690369	2011
The structure of barmah forest virus as revealed by cryo-electron microscopy at a 6-angstrom resolution has detailed transmembrane protein architecture and interactions. Journal of virology\| PubMed ID: 21752915	2011
Flexible architecture of IP3R1 by Cryo-EM. Structure (London, England : 1993)\| PubMed ID: 21827954	2011
4.4 Å cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus. The EMBO journal\| PubMed ID: 21829169	2011
Near-atomic-resolution cryo-EM for molecular virology. Current opinion in virology\| PubMed ID: 21845206	2011
A Unique BSL-3 Cryo-Electron Microscopy Laboratory at UTMB. Applied biosafety : journal of the American Biological Safety Association\| PubMed ID: 21852942	2010
Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. The EMBO journal\| PubMed ID: 22045336	2012
Filamentous, mixed micelles of triblock copolymers enhance tumor localization of indocyanine green in a murine xenograft model. Molecular pharmaceutics\| PubMed ID: 22118658	2012
Direct electron detection yields cryo-EM reconstructions at resolutions beyond 3/4 Nyquist frequency. Journal of structural biology\| PubMed ID: 22285189	2012
Reconstructing virus structures from nanometer to near-atomic resolutions with cryo-electron microscopy and tomography. Advances in experimental medicine and biology\| PubMed ID: 22297510	2012
Outcome of the first electron microscopy validation task force meeting. Structure (London, England : 1993)\| PubMed ID: 22325770	2012
Paraneoplastic thrombocytosis in ovarian cancer. The New England journal of medicine\| PubMed ID: 22335738	2012
Supramolecular non-amyloid intermediates in the early stages of α-synuclein aggregation. Biophysical journal\| PubMed ID: 22404935	2012
Constructing and validating initial Cα models from subnanometer resolution density maps with pathwalking. Structure (London, England : 1993)\| PubMed ID: 22405004	2012
An examination of the electrostatic interactions between the N-terminal tail of the Brome Mosaic Virus coat protein and encapsidated RNAs. Journal of molecular biology\| PubMed ID: 22472420	2012
The molecular architecture of the eukaryotic chaperonin TRiC/CCT. Structure (London, England : 1993)\| PubMed ID: 22503819	2012
The 2010 cryo-EM modeling challenge. Biopolymers\| PubMed ID: 22696402	2012
Gorgon and pathwalking: macromolecular modeling tools for subnanometer resolution density maps. Biopolymers\| PubMed ID: 22696403	2012
Comparison of Segger and other methods for segmentation and rigid-body docking of molecular components in cryo-EM density maps. Biopolymers\| PubMed ID: 22696409	2012
A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions. PLoS pathogens\| PubMed ID: 23055933	2012
Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell\| PubMed ID: 23178122	2012
EMEN2: an object oriented database and electronic lab notebook. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada\| PubMed ID: 23360752	2013
Cryo-EM structure of a molluscan hemocyanin suggests its allosteric mechanism. Structure (London, England : 1993)\| PubMed ID: 23541894	2013
Cryo-EM model validation using independent map reconstructions. Protein science : a publication of the Protein Society\| PubMed ID: 23592445	2013
Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers. The Journal of biological chemistry\| PubMed ID: 23612981	2013
Validation of cryo-EM structure of IP₃R1 channel. Structure (London, England : 1993)\| PubMed ID: 23707684	2013
Visualizing GroEL/ES in the act of encapsulating a folding protein. Cell\| PubMed ID: 23746846	2013
Validated near-atomic resolution structure of bacteriophage epsilon15 derived from cryo-EM and modeling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23840063	2013
TRiC's tricks inhibit huntingtin aggregation. eLife\| PubMed ID: 23853712	2013
Exploring new limits in complex biological structures. Current opinion in structural biology\| PubMed ID: 24076042	2013
Visualizing virus assembly intermediates inside marine cyanobacteria. Nature\| PubMed ID: 24107993	2013
Reprogramming an ATP-driven protein machine into a light-gated nanocage. Nature nanotechnology\| PubMed ID: 24270642	2013