Aaron M. Leconte

Polymerase evolution: efforts toward expansion of the genetic code.

An efficiently extended class of unnatural base pairs.

Efforts towards expansion of the genetic alphabet: pyridone and methyl pyridone nucleobases.

Amplify this! DNA and RNA get a third base pair.

Stability and polymerase recognition of pyridine nucleobase analogues: role of minor-groove H-bond acceptors.

Chemical biology: a broader take on DNA.

Minor groove hydrogen bonds and the replication of unnatural base pairs.

Polymerase recognition and stability of fluoro-substituted pyridone nucleobase analogues.

Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet.

Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication.

Directed evolution of DNA polymerases for next-generation sequencing.

Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase.

Discovery and biological characterization of geranylated RNA in bacteria.

A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes.

Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution.

Taq DNA Polymerase Mutants and 2'-Modified Sugar Recognition.

Design and Discovery of New Combinations of Mutant DNA Polymerases and Modified DNA Substrates.