Chang-Shi Chen

Institute of Basic Medical Sciences,
College of Medicine,
Department of Biochemistry and Molecular Biology,
Institute of Basic Medical Sciences, College of Medicine,
Department of Biochemistry and Molecular Biology, College of Medicine

National Cheng Kung University

BIOGRAPHY

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PUBLICATIONS

WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.

PloS one Mar, 2010 | Pubmed ID: 20209166

Genome sequence of a novel human pathogen, Aeromonas aquariorum.

Journal of bacteriology Aug, 2012 | Pubmed ID: 22815437

SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans.

Experimental gerontology Mar, 2013 | Pubmed ID: 23318476

Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism.

Biochemical and biophysical research communications May, 2013 | Pubmed ID: 23624506

Immobilization of the nematode Caenorhabditis elegans with addressable light-induced heat knockdown (ALINK).

Lab on a chip Aug, 2013 | Pubmed ID: 23719845

Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease.

Neuropharmacology Jul, 2014 | Pubmed ID: 23973292

n-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease.

PloS one , 2014 | Pubmed ID: 24416384

Virulence diversity among bacteremic Aeromonas isolates: ex vivo, animal, and clinical evidences.

PloS one , 2014 | Pubmed ID: 25375798

Aeromonas stool isolates from individuals with or without diarrhea in southern Taiwan: Predominance of Aeromonas veronii.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi Dec, 2015 | Pubmed ID: 25440979

Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans.

The Biochemical journal Aug, 2015 | Pubmed ID: 26251453

In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA.

The Journal of antimicrobial chemotherapy Feb, 2016 | Pubmed ID: 26553845

Exercise in an electrotactic flow chamber ameliorates age-related degeneration in Caenorhabditis elegans.

Scientific reports Jun, 2016 | Pubmed ID: 27305857

Mutation of the Enterohemorrhagic Escherichia coli Core LPS Biosynthesis Enzyme RfaD Confers Hypersusceptibility to Host Intestinal Innate Immunity In vivo.

Frontiers in cellular and infection microbiology , 2016 | Pubmed ID: 27570746

HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.

Autophagy Feb, 2017 | Pubmed ID: 27875098

A Disease Model of Muscle Necrosis Caused byInfection in.

Frontiers in microbiology , 2016 | Pubmed ID: 28101079

Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus.

Molecules (Basel, Switzerland) Dec, 2017 | Pubmed ID: 29271946

Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson's Disease.

Cell transplantation Dec, 2017 | Pubmed ID: 29390878

A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli.

Cell death & disease Mar, 2018 | Pubmed ID: 29515100

RIOK-1 Is a Suppressor of the p38 MAPK Innate Immune Pathway in .

Frontiers in immunology , 2018 | Pubmed ID: 29719537

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity.

European journal of medicinal chemistry Oct, 2018 | Pubmed ID: 30227353

INSTITUTIONS

National Cheng Kung University

JOVE ARTICLES

Detection of Enterohemorrhagic Escherichia Coli Colonization in Murine Host by Non-invasive In Vivo Bioluminescence System

Cheng-Ju Kuo^1,2,

Sin-Tian Wang^1,2,

Chang-Shi Chen^1,2

¹Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University,

²Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University

Immunology and Infection

Evaluating Virulence and Pathogenesis of Aeromonas Infection in a Caenorhabditis elegans Model

Yi-Wei Chen¹,

Wen-Chien Ko^1,2,

Chang-Shi Chen^1,3,

Po-Lin Chen^2,4

¹Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University,

²Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University,

³Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University,

⁴Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University

Immunology and Infection

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