Christiaan Leeuwenburgh

C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels.

Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats.

Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction.

Lifelong aspirin supplementation as a means to extending life span.

Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition.

WITHDRAWN: Life-long caloric restriction counteracts apoptotic effects of aging in the brain and bolsters the action of apoptosis inhibitors.

A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration.

C-reactive protein genotype affects exercise training-induced changes in insulin sensitivity.

Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6.

Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise.

Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise.

Oxidative damage and platelet activation as new predictors of mobility disability and mortality in elders.

Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study.

Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study.

Skeletal muscle apoptosis, sarcopenia and frailty at old age.

Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice.

Cardiac mitochondrial bioenergetics, oxidative stress, and aging.

Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus.

Autophagy in the heart and liver during normal aging and calorie restriction.

Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2'-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress.

Comparison of lifelong and late life exercise on oxidative stress in the cerebellum.

The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging.

Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats.

Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.

Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat.

Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy.

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle.

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.

Iron accumulation with age, oxidative stress and functional decline.

Molecular inflammation: underpinnings of aging and age-related diseases.

Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans.

Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults.

Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases.

Radical scavenging and reducing ability of tilapia (Oreochromis niloticus) protein hydrolysates.

Mitochondrial iron accumulation with age and functional consequences.

Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging.

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA.

Changes in lipid distribution during aging and its modulation by calorie restriction.

Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction.

Hydrogen sulfide induces oxidative damage to RNA and DNA in a sulfide-tolerant marine invertebrate.

Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction.

Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity.

Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction.

Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy.

Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome.

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.

Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise.

Cellular mechanisms of cardioprotection by calorie restriction: state of the science and future perspectives.

Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men.

Myeloperoxidase levels and mortality in frail community-living elderly individuals.

Biochemical indices as correlates of recent growth in juvenile green turtles (Chelonia mydas).

Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging.

Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves.

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging.

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.

Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats.

The hydrogen sulfide signaling system: changes during aging and the benefits of caloric restriction.

Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profile.

Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.

Myogenic and proteolytic mRNA expression following blood flow restricted exercise.

Dietary restriction: standing up for sirtuins.

New insights into the role of mitochondria in aging: mitochondrial dynamics and more.

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.

Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.

Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial.

Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions.

Mitochondria and aging.

Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice.

Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty - a mini-review.

Redox balance in the aging microcirculation: new friends, new foes, and new clinical directions.

The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity.

Age-related differences in lower extremity tissue compartments and associations with physical function in older adults.

Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy.

Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study.

Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae.

Critical role of autophage in ischemia/reperfusion injury to aged livers.

Chronic pain, perceived stress, and cellular aging: an exploratory study.

Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.

Impaired iron status in aging research.

Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities.

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals.

Urinary CTX-II concentrations are elevated and associated with knee pain and function in subjects with ACL reconstruction.

Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding.

Guidelines for the use and interpretation of assays for monitoring autophagy.

Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.

The effect of fasting on indicators of muscle damage.

Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity.

Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast.

Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults.

Oxidative damage increases with reproductive energy expenditure and is reduced by food-supplementation.

Fasting or caloric restriction for healthy aging.

Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals.

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics.

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials.

Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver.

Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm.

Aged mice are unable to mount an effective myeloid response to sepsis.

Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.

A better understanding of why murine models of trauma do not recapitulate the human syndrome.

Caloric Restriction to Moderate Senescence: Mechanisms and Clinical Utility.

Protective immunity and defects in the neonatal and elderly immune response to sepsis.

A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat.

Host responses to sepsis vary in different low-lethality murine models.

Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study.

Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity.

The authors reply.

Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery.

Brown adipose tissue and the cold war against obesity.

Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism.

Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: a partial least squares-discriminant analysis approach.

Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise.

Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.

Current nutritional recommendations and novel dietary strategies to manage sarcopenia.

Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects.

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged.

Age-related cellular changes in the long-lived bivalve A. islandica.

Calorie restriction for optimal cardiovascular aging: the weight of evidence.

Successful aging: Advancing the science of physical independence in older adults.

Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle.

Low- Versus High-Intensity Plyometric Exercise During Rehabilitation After Anterior Cruciate Ligament Reconstruction.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle.

Autophagy in the liver: cell's cannibalism and beyond.

Integrated control of brown adipose tissue.

"What makes some rats live so long?" The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content.

Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion.

Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study.

Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers.

Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study.

Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice.

Systemic inflammation, body composition, and physical performance in old community-dwellers.

Erratum to: Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study.

Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery Disease: The RESTORE Randomized Clinical Trial.

Exercise-Induced Autophagy in Fatty Liver Disease.

Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation.

Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets.

ENabling Reduction of Low-grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design.

Effects of Popular Diets without Specific Calorie Targets on Weight Loss Outcomes: Systematic Review of Findings from Clinical Trials.

Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.

Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults.

Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial.

HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study.

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.

Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders.

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.

Persistent injury-associated anemia in aged rats.

Persistent injury-associated anemia and aging: Novel insights.

Peripheral artery disease, calf skeletal muscle mitochondrial DNA copy number, and functional performance.

The "BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons" (BIOSPHERE) study: Rationale, design and methods.

Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers.

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart.

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing.

HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock.

Persistent inflammation and anemia among critically ill septic patients.

Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial.

Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in the Rat Heart.

Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise.

Glycine supplementation extends lifespan of male and female mice.

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats.

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.

Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease.

The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study.

Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.

LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock.

Differential response to targeted acupuncture by gender in patients with gastrointestinal cancer cachexia: secondary analysis of a randomized controlled trial.

Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.

Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.

Comparing 6-minute walk versus treadmill walking distance as outcomes in randomized trials of peripheral artery disease.

American Heart Association Vascular Disease Strategically Focused Research Network.

Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The COCOA-PAD Pilot Randomized Clinical Trial.

Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.

Meaningful change in 6-minute walk in people with peripheral artery disease.

Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease.

Clinical characteristics and response to supervised exercise therapy of people with lower extremity peripheral artery disease.

Nicotinamide riboside-A missing piece in the puzzle of exercise therapy for older adults?

Associations of Poly (ADP-Ribose) Polymerase1 abundance in calf skeletal muscle with walking performance in peripheral artery disease.

Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.

Mitochondrial DNA damage in calf skeletal muscle and walking performance in people with peripheral artery disease.

Skeletal Muscle Pathology in Peripheral Artery Disease: A Brief Review.

Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.

Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.

The Effect of Aging Physiology on Critical Care.

Innovations in Geroscience to enhance mobility in older adults.

Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults.

Vascular dysfunction as a potential culprit of sarcopenia.

Lipid intensive drug therapy for sepsis pilot: A Bayesian phase I clinical trial.

A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response.

The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver.

Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis.

Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease: The LITE Randomized Clinical Trial.

Sustained physical activity in peripheral artery disease: Associations with disease severity, functional performance, health-related quality of life, and subsequent serious adverse events in the LITE randomized clinical trial.

Assessing the feasibility of using the short physical performance battery to measure function in the immediate postoperative period after total knee replacement.

Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness.

Lipid and lipoprotein predictors of functional outcomes and long-term mortality after surgical sepsis.

Walking Exercise Therapy Effects on Lower Extremity Skeletal Muscle in Peripheral Artery Disease.

The COVID-19 pandemic and physical activity.

The impact of sarcopenia and acute muscle mass loss on long-term outcomes in critically ill patients with intra-abdominal sepsis.

Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors.

Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers.

Blood flow restriction exercise to attenuate postoperative loss of function after total knee replacement: a randomized pilot study.

Comparative toxicities of BPA, BPS, BPF, and TMBPF in the nematode Caenorhabditis elegans and mammalian fibroblast cells.

A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes.

Iron homeostasis and organismal aging.

Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999-2006.

Sex differences associate with late microbiome alterations after murine surgical sepsis.

Mitochondrial-derived vesicles in skeletal muscle remodeling and adaptation.

Post-meeting report of the 2022 On-site Padua Days on Muscle and Mobility Medicine, March 30 - April 3, 2022, Padua, Italy.

Time-Restricted Eating Regimen Differentially Affects Circulatory miRNA Expression in Older Overweight Adults.

Frailty and risk of mortality in older cancer survivors and adults without a cancer history: Evidence from the National Health and Nutrition Examination Survey, 1999-2014.

Analysis of Biological Aging and Risks of All-Cause and Cardiovascular Disease-Specific Death in Cancer Survivors.

Effects of Walking Exercise at a Pace With Versus Without Ischemic Leg Symptoms on Functional Performance Measures in People With Lower Extremity Peripheral Artery Disease: The LITE Randomized Clinical Trial.

Effect of Telmisartan on Walking Performance in Patients With Lower Extremity Peripheral Artery Disease: The TELEX Randomized Clinical Trial.

Dysregulated Genes, MicroRNAs, Biological Pathways, and Gastrocnemius Muscle Fiber Types Associated With Progression of Peripheral Artery Disease: A Preliminary Analysis.

Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study.

Low muscle mass is associated with a higher risk of all-cause and cardiovascular disease-specific mortality in cancer survivors.

Cigarette smoking and mitochondrial dysfunction in peripheral artery disease.

Relationship between Mitochondrial Quality Control Markers, Lower Extremity Tissue Composition, and Physical Performance in Physically Inactive Older Adults.

Autophagy Meets Aging: An Overview.

Mitochondrial Complex Abundance, Mitophagy Proteins, and Physical Performance in People With and Without Peripheral Artery Disease.

2023 Padua Days of Muscle and Mobility Medicine: post-meeting Book of Abstracts.

Transcriptomic and Proteomic of Gastrocnemius Muscle in Peripheral Artery Disease.

Inflammatory, mitochondrial, and senescence-related markers: Underlying biological pathways of muscle aging and new therapeutic targets.

The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration.

Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients.

Allostatic load and risk of all-cause, cancer-specific, and cardiovascular mortality in older cancer survivors: an analysis of the National Health and Nutrition Examination Survey 1999-2010.

Frontal adenosine triphosphate markers from P MRS are associated with cognitive performance in healthy older adults: preliminary findings.

Hospitalizations during home-based walking exercise interventions in peripheral artery disease: Results from two randomized clinical trials.

Study Design, Rationale, and Methodology for Promote Weight Loss in Patients With Peripheral Artery Disease Who Also Have Obesity: The PROVE Trial.

Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and are Reduced by Physical Activity in Older Adults.

Five Padua days on muscle and mobility medicine (2024Pdm3) 27 February - 2 March, 2024 at Hotel Petrarca, Thermae of Euganean Hills, Padua, and San Luca Hall, Prato della Valle, Padua, Italy.