Frauke Neff

Gene expression profiles derived from single cells in human postmortem brain.

Serial induction of mutations by ethylnitrosourea in PC12 cells: a new model for a phenotypical characterization of the neurotoxic response to 6-hydroxydopamine.

Gene expression profiling of Lewy body-bearing neurons in Parkinson's disease.

Neurologic outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats: description of a new model.

Regional vulnerability of mesencephalic dopaminergic neurons prone to degenerate in Parkinson's disease: a post-mortem study in human control subjects.

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.

Evaluation of a fibroelastoma with magnetic resonance imaging.

A 35-year-old woman with an intrasellar and suprasellar lesion.

Systemic inflammatory response syndrome increases immobility-induced neuromuscular weakness.

Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders.

Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC).

[Therapy of Alzheimer's disease: current status and future development].

APP transgenic mice: the effect of active and passive immunotherapy in cognitive tasks.

Y-box-binding protein YB-1 identifies high-risk patients with primary breast cancer benefiting from rapidly cycled tandem high-dose adjuvant chemotherapy.

The role of macrophage migration inhibitory factor in Alzheimer's disease.

Intravenous immunoglobulins as a treatment for Alzheimer's disease: rationale and current evidence.

Immunization as treatment for Parkinson's disease.

Mouse phenotyping.

Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma.

Validation of preclinical multiparametric imaging for prediction of necrosis in hepatocellular carcinoma after embolization.

Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease.

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation.

Loss of Roquin induces early death and immune deregulation but not autoimmunity.

STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors.

Therapeutic efficacy and toxicity of 225Ac-labelled vs. 213Bi-labelled tumour-homing peptides in a preclinical mouse model of peritoneal carcinomatosis.

Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation.

Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease.

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system.

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.

Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes.

Innovations in phenotyping of mouse models in the German Mouse Clinic.

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

An ENU mutagenesis-derived mouse model with a dominant Jak1 mutation resembling phenotypes of systemic autoimmune disease.

Rapamycin extends murine lifespan but has limited effects on aging.

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.

The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth.

Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production.

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

Multimodality multiparametric imaging of early tumor response to a novel antiangiogenic therapy based on anticalins.

Longevity, aging and rapamycin.

Pleiotropic functions for transcription factor zscan10.

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.

MiR-34a deficiency accelerates medulloblastoma formation in vivo.

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.

The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation.

Efficacy and Tolerability of a GD2-Directed Trifunctional Bispecific Antibody in a Preclinical Model: Subcutaneous Administration Is Superior to Intravenous Delivery.

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion.

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.