Hynek Wichterle

Directed differentiation of embryonic stem cells into motor neurons.

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex.

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification.

Functional properties of motoneurons derived from mouse embryonic stem cells.

New neurons follow the flow of cerebrospinal fluid in the adult brain.

Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo.

Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons.

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.

Differentiation of mouse embryonic stem cells to spinal motor neurons.

Xenotransplantation of embryonic stem cell-derived motor neurons into the developing chick spinal cord.

Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding.

What can pluripotent stem cells teach us about neurodegenerative diseases?

Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation.

Global control of motor neuron topography mediated by the repressive actions of a single hox gene.

Programming embryonic stem cells to neuronal subtypes.

MicroRNA regulation of neural stem cells and neurogenesis.

Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis.

A functionally characterized test set of human induced pluripotent stem cells.

Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop.

An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming.

Embryonic stem cell-based mapping of developmental transcriptional programs.

Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues.