Hyungshin Yim

Cdk2 activity is associated with depolarization of mitochondrial membrane potential during apoptosis.

Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis.

Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.

Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species- and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells.

Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis.

ATR (AT mutated Rad3 related) activity stabilizes Cdc6 and delays G2/M-phase entry during hydroxyurea-induced S-phase arrest of HeLa cells.

Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.

Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.

Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2).

DNA-binding and regulatory properties of the transcription factor and putative tumor suppressor p150(Sal2).

Nek1 and TAZ interact to maintain normal levels of polycystin 2.

Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase.

Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis.

The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC.

Phosphorylation of Cdc6 at serine 74, but not at serine 106, drives translocation of Cdc6 to the cytoplasm.

The accumulation of DNA repair defects is the molecular origin of carcinogenesis.

Current clinical trials with polo-like kinase 1 inhibitors in solid tumors.

Two nuclear export signals of Cdc6 are differentially associated with CDK-mediated phosphorylation residues for cytoplasmic translocation.

Synergistic effect of simvastatin plus NS398 on inhibition of proliferation and survival in hepatocellular carcinoma cell line.

ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-α-induced apoptosis of HeLa cells.

Plk1-targeted therapies in TP53- or RAS-mutated cancer.

Predictive value of urinary and serum biomarkers in young children with febrile urinary tract infections.

A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition.

The tumor suppressor protein p150(Sal2) in carcinogenesis.

Differential Cellular Effects of Plk1 Inhibitors Targeting the ATP-binding Domain or Polo-box Domain.

Antiinflammatory and analgesic effects of Eurycoma longifolia extracts.

Sensitivity of TP53-Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated With Direct Inhibition of Plk1 Activity.

Roles of SALL2 in tumorigenesis.

Comparative Analysis of a FRET-based PLK1 Kinase Assay to Identify PLK1 inhibitors for Chemotherapy.