Johnny Huard

Gene therapy and tissue engineering in orthopaedic surgery.

Genetic engineering of meniscal allografts.

Muscle injuries and repair: current trends in research.

The use of ex vivo gene transfer based on muscle-derived stem cells for cardiovascular medicine.

Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration.

Enhancement of tendon-bone integration of anterior cruciate ligament grafts with bone morphogenetic protein-2 gene transfer: a histological and biomechanical study.

Insulin growth factor-1 decreases muscle atrophy following denervation.

Adenovirus mediated gene transfer to skeletal muscle.

Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2.

BMP4-expressing muscle-derived stem cells differentiate into osteogenic lineage and improve bone healing in immunocompetent mice.

Muscle-based gene therapy and tissue engineering for treatment of growth plate injuries.

肌源性细胞分化为成纤维细胞中受伤骨骼肌。

Gene therapy and tissue engineering based on muscle-derived stem cells.

Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defects.

Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4.

Effect of cryoinjury on the contractile parameters of bladder strips: a model of impaired detrusor contractility.

The role of CD34 expression and cellular fusion in the regeneration capacity of myogenic progenitor cells.

Muscle derived cell mediated ex vivo gene transfer to the lower urinary tract: comparison of viral vectors.

Muscle-based gene therapy and tissue engineering to improve bone healing.

Gene therapy and tissue engineering for sports medicine.

Gene therapy in orthopaedic surgery.

Antifibrotic effects of suramin in injured skeletal muscle after laceration.

Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential.

Muscle-derived stem cells seeded into acellular scaffolds develop calcium-dependent contractile activity that is modulated by nicotinic receptors.

Stem cells in the treatment of muscle and connective tissue diseases.

Gamma interferon as an antifibrosis agent in skeletal muscle.

Improvement of muscle healing through enhancement of muscle regeneration and prevention of fibrosis.

Gene therapy to improve osteogenesis in bone lesions with severe soft tissue damage.

Development of an experimental system for the study of urethral biomechanical function.

The role of cell type in bone healing mediated by ex vivo gene therapy.

Dystrophin delivery in dystrophin-deficient DMDmdx skeletal muscle by isogenic muscle-derived stem cell transplantation.

Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra.

Muscle-derived stem cells: potential for muscle regeneration.

Retroviral delivery of Noggin inhibits the formation of heterotopic ossification induced by BMP-4, demineralized bone matrix, and trauma in an animal model.

Muscle-derived stem cells.

Noninvasive monitoring of stem cell transfer for muscle disorders.

Establishing reliable criteria for isolating myogenic cell fractions with stem cell properties and enhanced regenerative capacity.

Gene transfer to skeletal muscle using herpes simplex virus-based vectors.

Ex vivo gene transfer to mature skeletal muscle by using adenovirus helper cells.

Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis.

Converse relationship between in vitro osteogenic differentiation and in vivo bone healing elicited by different populations of muscle-derived cells genetically engineered to express BMP4.

Intraurethral muscle-derived cell injections increase leak point pressure in a rat model of intrinsic sphincter deficiency.

Muscle-derived stem cells for musculoskeletal tissue regeneration and repair.

Ex vivo gene therapy-induced endochondral bone formation: comparison of muscle-derived stem cells and different subpopulations of primary muscle-derived cells.

Development of a self-inactivating tet-on retroviral vector expressing bone morphogenetic protein 4 to achieve regulated bone formation.

Biaxial mechanical properties of muscle-derived cell seeded small intestinal submucosa for bladder wall reconstitution.

Structural and functional healing of critical-size segmental bone defects by transduced muscle-derived cells expressing BMP4.

Tissue engineering with muscle-derived stem cells.

Noninvasive monitoring and tracking of muscle stem cell transplants.

The use of suramin, an antifibrotic agent, to improve muscle recovery after strain injury.

The vascular wall as a source of stem cells.

Noggin improves bone healing elicited by muscle stem cells expressing inducible BMP4.

Differential effect of BMP4 on NIH/3T3 and C2C12 cells: implications for endochondral bone formation.

Initial failure in myoblast transplantation therapy has led the way toward the isolation of muscle stem cells: potential for tissue regeneration.

Differential myocardial infarct repair with muscle stem cells compared to myoblasts.

Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions.

The effect of relaxin treatment on skeletal muscle injuries.

NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis.

Cell therapy for muscle regeneration and repair.

VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis.

Influence of BMPs on the formation of osteoblastic lesions in metastatic prostate cancer.

Musculoskeletal gene therapy and its potential use in the treatment of complicated musculoskeletal infection.

Biomechanical characterization of the urethral musculature.

Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells.

Nerve growth factor improves the muscle regeneration capacity of muscle stem cells in dystrophic muscle.

Inhibited skeletal muscle healing in cyclooxygenase-2 gene-deficient mice: the role of PGE2 and PGF2alpha.

Mouse adipose-derived stem cells undergo multilineage differentiation in vitro but primarily osteogenic and chondrogenic differentiation in vivo.

Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence.

VEGF and BMP expression in mouse osteosarcoma cells.

Gene therapy and tissue engineering in orthopaedic surgery.

Mixed metastatic lung cancer lesions in bone are inhibited by noggin overexpression and Rank:Fc administration.

Stem and progenitor cells in skeletal muscle development, maintenance, and therapy.

Thermosensitive hydrogel PEG-PLGA-PEG enhances engraftment of muscle-derived stem cells and promotes healing in diabetic wound.

A role for cell sex in stem cell-mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency.

Noggin inhibits postoperative resynostosis in craniosynostotic rabbits.

Tissue engineering and developmental biology: going biomimetic.

Matrix metalloproteinase-1 therapy improves muscle healing.

Regenerative medicine in orthopaedic surgery.

Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals.

Skeletal muscle fiber type conversion during the repair of mouse soleus: potential implications for muscle healing after injury.

Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis.

Osteogenic potential of postnatal skeletal muscle-derived stem cells is influenced by donor sex.

Decorin gene transfer promotes muscle cell differentiation and muscle regeneration.

Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury.

Prospective identification of myogenic endothelial cells in human skeletal muscle.

Microenvironments engineered by inkjet bioprinting spatially direct adult stem cells toward muscle- and bone-like subpopulations.

Muscle-derived stem cells for tissue engineering and regenerative therapy.

[The sex of muscle stem cells: must it be taken into account?].

A relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts.

In vitro interaction between muscle-derived stem cells and nucleus pulposus cells.

Development of a tissue-engineered vascular graft combining a biodegradable scaffold, muscle-derived stem cells and a rotational vacuum seeding technique.

Regenerative medicine for the musculoskeletal system based on muscle-derived stem cells.

Sex differences in muscle-derived stem cells and skeletal muscle.

Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation.

Matrix metalloproteinase-1 treatment of muscle fibrosis.

Purification and long-term culture of multipotent progenitor cells affiliated with the walls of human blood vessels: myoendothelial cells and pericytes.

Angiotensin II receptor blockade administered after injury improves muscle regeneration and decreases fibrosis in normal skeletal muscle.

Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth.

Purification and culture of human blood vessel-associated progenitor cells.

Isolation of a slowly adhering cell fraction containing stem cells from murine skeletal muscle by the preplate technique.

A perivascular origin for mesenchymal stem cells in multiple human organs.

Antioxidant levels represent a major determinant in the regenerative capacity of muscle stem cells.

The influence of sex on the chondrogenic potential of muscle-derived stem cells: implications for cartilage regeneration and repair.

Myogenic endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infarcted myocardium.

Bone regeneration mediated by BMP4-expressing muscle-derived stem cells is affected by delivery system.

Stem cells for the treatment of skeletal muscle injury.

Re: Angiotensin II receptor blockade administered after injury improves muscle regeneration and decreases fibrosis in normal skeletal muscle.

Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cells.

Functional overloading of dystrophic mice enhances muscle-derived stem cell contribution to muscle contractile capacity.

The effect of muscle loading on skeletal muscle regenerative potential: an update of current research findings relating to aging and neuromuscular pathology.

Ex vivo Noggin gene therapy inhibits bone formation in a mouse model of postoperative resynostosis.

The dose of growth factors influences the synergistic effect of vascular endothelial growth factor on bone morphogenetic protein 4-induced ectopic bone formation.

Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1.

Sex of muscle stem cells does not influence potency for cardiac cell therapy.

A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle-derived stem cells.

Effect of VEGF on the regenerative capacity of muscle stem cells in dystrophic skeletal muscle.

The synergistic effect of treadmill running on stem-cell transplantation to heal injured skeletal muscle.

In vivo assessment of a tissue-engineered vascular graft combining a biodegradable elastomeric scaffold and muscle-derived stem cells in a rat model.

Perivascular multi-lineage progenitor cells in human organs: regenerative units, cytokine sources or both?

Inkjet-based biopatterning of bone morphogenetic protein-2 to spatially control calvarial bone formation.

Cutting-edge muscle recovery: using antifibrosis agents to improve healing.

AAV-directed muscular dystrophy gene therapy.

Platelets in regeneration.

Testing the critical size in calvarial bone defects: revisiting the concept of a critical-size defect.

Effect of phosphatidyl inositol 3-kinase, extracellular signal-regulated kinases 1/2, and p38 mitogen-activated protein kinase inhibition on osteogenic differentiation of muscle-derived stem cells.

Cellular antioxidant levels influence muscle stem cell therapy.

Differential efficacy of gels derived from small intestinal submucosa as an injectable biomaterial for myocardial infarct repair.

Pericyte-based human tissue engineered vascular grafts.

Skeletal muscle-derived stem cells differentiate into hepatocyte-like cells and aid in liver regeneration.

Placental perivascular cells for human muscle regeneration.

Accelerated aging of intervertebral discs in a mouse model of progeria.

IOC consensus paper on the use of platelet-rich plasma in sports medicine.

Lentivirus-mediated Wnt11 gene transfer enhances Cardiomyogenic differentiation of skeletal muscle-derived stem cells.

Study of muscle cell dedifferentiation after skeletal muscle injury of mice with a Cre-Lox system.

Engineering spatial control of multiple differentiation fates within a stem cell population.

Use of an ultrasonic blade facilitates muscle repair after incision injury.

Follistatin improves skeletal muscle healing after injury and disease through an interaction with muscle regeneration, angiogenesis, and fibrosis.

Identification and characterization of chondrogenic progenitor cells in the fascia of postnatal skeletal muscle.

Isolation and Characterization of Human Anterior Cruciate Ligament-Derived Vascular Stem Cells.

Terminal differentiation is not a major determinant for the success of stem cell therapy - cross-talk between muscle-derived stem cells and host cells.

Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis.

Intramuscular transplantation of muscle-derived stem cells accelerates skeletal muscle healing after contusion injury via enhancement of angiogenesis.

Role of angiogenesis after muscle derived stem cell transplantation in injured medial collateral ligament.

Venous graft-derived cells participate in peripheral nerve regeneration.

Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of ischemic hearts.

Skeletal muscle-derived stem cells: implications for cell-mediated therapies.

NF-κB Negatively Impacts the Myogenic Potential of Muscle-derived Stem Cells.

Murine and human myogenic cells identified by elevated aldehyde dehydrogenase activity: implications for muscle regeneration and repair.

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model.

Biologic approaches to enhance rotator cuff healing after injury.

Mechanical Loading of Stem Cells for Improvement of Transplantation Outcome: The Role of Loading History.

Biological approaches to improve skeletal muscle healing after injury and disease.

Isolation of myogenic stem cells from cultures of cryopreserved human skeletal muscle.

Human blood-vessel-derived stem cells for tissue repair and regeneration.

Timing of the administration of suramin treatment after muscle injury.

NF-κB inhibition delays DNA damage-induced senescence and aging in mice.

Effect of host sex and sex hormones on muscle-derived stem cell-mediated bone formation and defect healing.

Therapeutic potential of anterior cruciate ligament-derived stem cells for anterior cruciate ligament reconstruction.

Developing cardiac and skeletal muscle share fast-skeletal myosin heavy chain and cardiac troponin-I expression.

Dystrophin and utrophin "double knockout" dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities.

The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury.

Human pericytes for ischemic heart repair.

Stem cells, angiogenesis and muscle healing: a potential role in massage therapies?

The effect of a heparin-based coacervate of fibroblast growth factor-2 on scarring in the infarcted myocardium.

BMP2 is superior to BMP4 for promoting human muscle derived-stem cell mediated bone regeneration in a critical size calvarial defect model.

The use of blood vessel-derived stem cells for meniscal regeneration and repair.

Therapeutic advantage in selective ligament augmentation for partial tears of the anterior cruciate ligament: results in an animal model.

Muscle-derived stem cell sheets support pump function and prevent cardiac arrhythmias in a model of chronic myocardial infarction.

Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases.

Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces.

Rapamycin Inhibits ALDH Activity, Resistance to Oxidative Stress, and Metastatic Potential in Murine Osteosarcoma Cells.

Neuromuscular electrical stimulation as a method to maximize the beneficial effects of muscle stem cells transplanted into dystrophic skeletal muscle.

Muscle-derived stem/progenitor cell dysfunction in Zmpste24-deficient progeroid mice limits muscle regeneration.

Human myogenic endothelial cells exhibit chondrogenic and osteogenic potentials at the clonal level.

Tendon graft revitalization using adult anterior cruciate ligament (ACL)-derived CD34+ cell sheets for ACL reconstruction.

RhoA mediates defective stem cell function and heterotopic ossification in dystrophic muscle of mice.

Beneficial effect of mechanical stimulation on the regenerative potential of muscle-derived stem cells is lost by inhibiting vascular endothelial growth factor.

Chick embryo extract demethylates tumor suppressor genes in osteosarcoma cells.

Platelet-rich plasma promotes the proliferation of human muscle derived progenitor cells and maintains their stemness.

Use of an antifibrotic agent improves the effect of platelet-rich plasma on muscle healing after injury.

Notch Signaling is Associated with ALDH Activity and an Aggressive Metastatic Phenotype in Murine Osteosarcoma Cells.

Sustained release of bone morphogenetic protein 2 via coacervate improves the osteogenic potential of muscle-derived stem cells.

The role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair.

Cellular kinetics of perivascular MSC precursors.

Stem cells, angiogenesis and muscle healing: a potential role in massage therapies?

The microenvironment-specific transformation of adult stem cells models malignant triton tumors.

Development of a web course on gene therapy by the international consortium of gene therapy.

Human muscle-derived stem/progenitor cells promote functional murine peripheral nerve regeneration.

Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin-/- mice.

Role of donor and host cells in muscle-derived stem cell-mediated bone repair: differentiation vs. paracrine effects.

A comparison of bone regeneration with human mesenchymal stem cells and muscle-derived stem cells and the critical role of BMP.

Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence.

Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.

Characterization of a compartment syndrome-like injury model.

Does fibrin clot really enhance graft healing after double-bundle ACL reconstruction in a caprine model?

ALDH Activity Correlates with Metastatic Potential in Primary Sarcomas of Bone.

Human myocardial pericytes: multipotent mesodermal precursors exhibiting cardiac specificity.

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis.

Biologic strategies to improve nerve regeneration after peripheral nerve repair.

The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophy.

The role of stem cells and tissue engineering in orthopaedic sports medicine: current evidence and future directions.

Gene therapy approaches to regenerating the musculoskeletal system.

Activation of non-myogenic mesenchymal stem cells during the disease progression in dystrophic dystrophin/utrophin knockout mice.

Gene and cell therapy for muscle regeneration.

The effect of blocking angiogenesis on anterior cruciate ligament healing following stem cell transplantation.

Two-stage therapeutic utility of ectopically formed bone tissue in skeletal muscle induced by adeno-associated virus containing bone morphogenetic protein-4 gene.

MMP1 gene expression enhances myoblast migration and engraftment following implanting into mdx/SCID mice.

Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors.

Stem cells isolated from human dental pulp and amniotic fluid improve skeletal muscle histopathology in mdx/SCID mice.

Controlled dual delivery of fibroblast growth factor-2 and Interleukin-10 by heparin-based coacervate synergistically enhances ischemic heart repair.

Retinal Targets ALDH Positive Cancer Stem Cell and Alters the Phenotype of Highly Metastatic Osteosarcoma Cells.

Customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle.

Cyclooxygenase-2 deficiency impairs muscle-derived stem cell-mediated bone regeneration via cellular autonomous and non-autonomous mechanisms.

Biological Therapies for Cartilage Lesions in the Hip: A New Horizon.

Notch Signaling Mediates Skeletal Muscle Atrophy in Cancer Cachexia Caused by Osteosarcoma.

The Combined Use of Losartan and Muscle-Derived Stem Cells Significantly Improves the Functional Recovery of Muscle in a Young Mouse Model of Contusion Injuries.

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging.