Kwok-Fai Lau

Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines.

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.

Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.

X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.

Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task.

Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1.

Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.

An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.

Neuronal differentiation of C17.2 neural stem cells induced by a natural flavonoid, baicalin.

Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.

GULP1 is a novel APP-interacting protein that alters APP processing.

Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases.

Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo.

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.

Genomic organization and promoter cloning of the human X11α gene APBA1.

Promoter characterization and genomic organization of the human X11β gene APBA2.

Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.

DNA microarray expression analysis of baicalin-induced differentiation of C17.2 neural stem cells.

Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.

CAG expansion induces nucleolar stress in polyglutamine diseases.

FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth.

A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia.

The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling.

Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila.

Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity.

The lysosomal protein cathepsin L is a progranulin protease.

Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing.

GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer's disease.

A peptidylic inhibitor for neutralizing expanded RNA-induced nucleolar stress in polyglutamine diseases.

Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.

Three SpoA-domain proteins interact in the creation of the flagellar type III secretion system in .

Planar cell polarity gene triggers apoptosis in neurodegenerative disease models.

Amyloid Precursor Protein Is Associated with Aggressive Behavior in Nonluminal Breast Cancers.

Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress.

Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene.

Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer.

A Peptidylic Inhibitor for Neutralizing (GGGGCC)-Associated Neurodegeneration in C9ALS-FTD.

Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.

The roles of atypical protein kinase Cs (aPKCs) in the nervous system: targets for neuroregeneration?

Micro-RNA Clusters Integrate Evolutionary Constraints on Expression and Target Affinities: The miR-6/5/4/286/3/309 Cluster in Drosophila.

ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.

Proximity Ligation Assay for the Investigation of the Intramolecular Interaction of ELMO1.

CAG RNAs induce DNA damage and apoptosis by silencing expression in polyglutamine degeneration.