Lauren O. Bakaletz

Recent advances in otitis media. 4. Anatomy, cell biology, pathology, and animal models.

Recent advances in otitis media. 5. Molecular biology and biochemistry.

Recent advances in otitis media. 6. Microbiology and immunology.

Recent advances in otitis media. 7. Vaccine.

Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention.

Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media.

Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media.

Anatomy of the nasal cavity in the chinchilla.

Efficacy of the 26-kilodalton outer membrane protein and two P5 fimbrin-derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx.

The fourth surface-exposed region of the outer membrane protein P5-homologous adhesin of nontypable Haemophilus influenzae is an immunodominant but nonprotective decoying epitope.

Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media.

Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway.

Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates.

Developing animal models for polymicrobial diseases.

A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media.

Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media.

Recent advances in otitis media. 3. Animal models; anatomy and pathology; pathogenesis; cell biology and genetics.

Recent advances in otitis media. 4A. Molecular biology.

Recent advances in otitis media. 4B. Biochemistry.

Recent advances in otitis media. 4C. Interaction between middle ear and inner ear in otitis media.

Recent advances in otitis media. 5. Microbiology and immunology.

Recent advances in otitis media. 6. Vaccine.

Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzae.

Vaccines for otitis media: proposals for overcoming obstacles to progress.

Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus.

Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear.

Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20.

Nontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expression.

Food commensal microbes as a potentially important avenue in transmitting antibiotic resistance genes.

Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae.

The non-typeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisition.

A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media.

Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media.

The OxyR regulon in nontypeable Haemophilus influenzae.

Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein.

Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo.

The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract.

Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation.

A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin.

Bacterial biofilms in otitis media: evidence and relevance.

Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells.

Innate immune defenses: finding a new way to calm the storm.

Nontypeable Haemophilus influenzae as a pathogen in children.

The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant.

Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae.

Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention.

Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates.

Immunopathogenesis of polymicrobial otitis media.

Microbial interactions in the respiratory tract.

Mapping the anatomy of respiratory syncytial virus infection of the upper airways in chinchillas (Chinchilla lanigera).

The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway.

Abrogation of nontypeable Haemophilus influenzae protein D function reduces phosphorylcholine decoration, adherence to airway epithelial cells, and fitness in a chinchilla model of otitis media.

Heme utilization by nontypeable Haemophilus influenzae is essential and dependent on Sap transporter function.

Use of the Chinchilla Model for Nasopharyngeal Colonization To Study Gene Expression by Moraxella catarrhalis.

Nontypeable Haemophilus influenzae type IV pili: biological roles of the products encoded by the pil and com operons.