Lesley Mathews Griner

Oncology Drug Discovery: Molecular Pharmacology

Novartis Institutes for BioMedical Research

BIOGRAPHY

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PUBLICATIONS

Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

Journal of medicinal chemistry Jun, 2017 | Pubmed ID: 28557458

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.

Cancer research Mar, 2018 | Pubmed ID: 29343524

INSTITUTIONS

Novartis Institutes for BioMedical Research

JOVE ARTICLES

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

Lesley Mathews Griner¹,

Kalyani Gampa¹,

Toan Do²,

Huyen Nguyen²,

David Farley²,

Christopher J. Hogan²,

Douglas S. Auld²,

Serena J. Silver¹

¹Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research,

²Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research

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Lesley Mathews Griner

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Oncology Drug Discovery: Molecular Pharmacology

Novartis Institutes for BioMedical Research

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

Oncology Drug Discovery: Molecular Pharmacology