Marie-Dominique Filippi

Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell-derived hematopoietic cells to thrombopoietin in vitro.

The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization.

Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.

Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.

Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways.

Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment.

Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils.

Rho GTPase Rac1 is critical for neutrophil migration into the lung.

GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis.

The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress.

Cutaneous infection with Metarhizium anisopliae in a patient with hypohidrotic ectodermal dysplasia and immune deficiency.

Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve.

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease.

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones.

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.

The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling.

Rho GTPases in hematopoiesis and hemopathies.

Differential effects of kidney-lung cross-talk during acute kidney injury and bacterial pneumonia.

Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules.

An efficient and reproducible process for transmission electron microscopy (TEM) of rare cell populations.

ATF3 is a novel regulator of mouse neutrophil migration.

New regulatory role for SRF in neutrophils.

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.

Neutrophils scan for activated platelets to initiate inflammation.

RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation.

Neutrophil actin regulation: MKL1 is in control.

Leukocyte transcellular diapedesis: Rap1b is in control.

Mechanism of Diapedesis: Importance of the Transcellular Route.