Michael B. Stout

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.

Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues.

Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia.

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α.

Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion.

Litter expansion alters metabolic homeostasis in a sex specific manner.

Mild calorie restriction, but not 17α-estradiol, extends ovarian reserve and fertility in female mice.

Obesity promotes lipid accumulation in mouse cartilage-A potential role of acetyl-CoA carboxylase (ACC) mediated chondrocyte de novo lipogenesis.

Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary.

Differential Regulation of Mouse Hippocampal Gene Expression Sex Differences by Chromosomal Content and Gonadal Sex.

17α-estradiol does not adversely affect sperm parameters or fertility in male mice: implications for reproduction-longevity trade-offs.

17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice.

A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes.