Muthiah Manoharan has not added Biography.
If you are Muthiah Manoharan and would like to personalize this page please email our Author Liaison for assistance.
A viral microRNA functions as an orthologue of cellular miR-155.
Nature Dec, 2007 | Pubmed ID: 18075594
The Journal of organic chemistry Jan, 2002 | Pubmed ID: 11798305
Biochemistry Jan, 2002 | Pubmed ID: 11802733
European journal of biochemistry / FEBS May, 2002 | Pubmed ID: 12027896
Antisense & nucleic acid drug development Apr, 2002 | Pubmed ID: 12074364
The Journal of pharmacology and experimental therapeutics Aug, 2002 | Pubmed ID: 12130724
2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA.
Biochemistry Oct, 2002 | Pubmed ID: 12269806
Nature biotechnology Dec, 2002 | Pubmed ID: 12426578
Improving antisense oligonucleotide binding to human serum albumin: dramatic effect of ibuprofen conjugation.
Chembiochem : a European journal of chemical biology Dec, 2002 | Pubmed ID: 12465035
High-affinity peptide nucleic acid oligomers containing tricyclic cytosine analogues.
Organic letters Dec, 2002 | Pubmed ID: 12465896
Angewandte Chemie (International ed. in English) Jan, 2002 | Pubmed ID: 12491456
RNA (New York, N.Y.) Dec, 2002 | Pubmed ID: 12515389
Bioconjugate chemistry Jan-Feb, 2003 | Pubmed ID: 12526688
2'-O-[2-(amino)-2-oxoethyl] oligonucleotides.
Organic letters Feb, 2003 | Pubmed ID: 12583729
Journal of the American Chemical Society Mar, 2003 | Pubmed ID: 12603111
Nucleic acids research Apr, 2003 | Pubmed ID: 12682357
Organic letters Jun, 2003 | Pubmed ID: 12790517
Organic letters Aug, 2003 | Pubmed ID: 12916967
Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo.
Antisense & nucleic acid drug development , 2003 | Pubmed ID: 12954113
Nucleic acids research. Supplement (2001) , 2003 | Pubmed ID: 14510407
Nucleic acids research , 2004 | Pubmed ID: 14762210
2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures.
Organic letters Jun, 2004 | Pubmed ID: 15176796
Nucleic acids research , 2004 | Pubmed ID: 15247346
The journal of gene medicine Oct, 2004 | Pubmed ID: 15386737
Nature Nov, 2004 | Pubmed ID: 15538359
Journal of the American Chemical Society Nov, 2004 | Pubmed ID: 15547979
Current opinion in chemical biology Dec, 2004 | Pubmed ID: 15556399
Nucleic acids research , 2004 | Pubmed ID: 15602001
Methods in enzymology , 2005 | Pubmed ID: 15644187
Nature medicine Mar, 2005 | Pubmed ID: 15723075
Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Biochemistry Jun, 2005 | Pubmed ID: 15966728
Nucleic acids research , 2005 | Pubmed ID: 16170156
Journal of medicinal chemistry Oct, 2005 | Pubmed ID: 16220989
Silencing of microRNAs in vivo with 'antagomirs'.
Nature Dec, 2005 | Pubmed ID: 16258535
Nature May, 2006 | Pubmed ID: 16565705
Biochemistry Apr, 2006 | Pubmed ID: 16566588
Journal of medicinal chemistry Apr, 2006 | Pubmed ID: 16610796
Nature chemical biology Dec, 2006 | Pubmed ID: 17108989
ACS chemical biology Apr, 2006 | Pubmed ID: 17163665
Nucleosides, nucleotides & nucleic acids , 2007 | Pubmed ID: 17365794
Cell Apr, 2007 | Pubmed ID: 17382377
Specificity, duplex degradation and subcellular localization of antagomirs.
Nucleic acids research , 2007 | Pubmed ID: 17439965
Nature biotechnology Oct, 2007 | Pubmed ID: 17873866
Nucleic acids research , 2007 | Pubmed ID: 17881374
Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway.
Nature Oct, 2007 | Pubmed ID: 17898712
Journal of medicinal chemistry May, 2008 | Pubmed ID: 18399648
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.
Nature biotechnology May, 2008 | Pubmed ID: 18438401
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2008 | Pubmed ID: 18695239
Oligonucleotides Mar, 2009 | Pubmed ID: 19093781
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene.
Cell host & microbe Jan, 2009 | Pubmed ID: 19154990
Development of lipidoid-siRNA formulations for systemic delivery to the liver.
Molecular therapy : the journal of the American Society of Gene Therapy May, 2009 | Pubmed ID: 19259063
Chemical communications (Cambridge, England) Apr, 2009 | Pubmed ID: 19333476
Antimicrobial agents and chemotherapy Sep, 2009 | Pubmed ID: 19506055
Rational design of cationic lipids for siRNA delivery.
Nature biotechnology Feb, 2010 | Pubmed ID: 20081866
Analytical biochemistry Jun, 2010 | Pubmed ID: 20156415
Journal of controlled release : official journal of the Controlled Release Society Jun, 2010 | Pubmed ID: 20170694
Nucleic acids research Aug, 2010 | Pubmed ID: 20403811
Organic letters May, 2010 | Pubmed ID: 20420425
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.
Molecular therapy : the journal of the American Society of Gene Therapy Jul, 2010 | Pubmed ID: 20461061
Proceedings of the National Academy of Sciences of the United States of America Jun, 2010 | Pubmed ID: 20534471
Analytical biochemistry Oct, 2010 | Pubmed ID: 20599656
Nucleic acids research Nov, 2010 | Pubmed ID: 20610434
Organic letters Dec, 2010 | Pubmed ID: 21049912
Chemistry & biology Dec, 2010 | Pubmed ID: 21168770
Nucleic acids research Apr, 2011 | Pubmed ID: 21183463
The Journal of organic chemistry Mar, 2011 | Pubmed ID: 21299239
Nucleic acids research Jun, 2011 | Pubmed ID: 21345934
Angewandte Chemie (International ed. in English) Mar, 2011 | Pubmed ID: 21351337
Bioconjugate chemistry Aug, 2011 | Pubmed ID: 21755983
MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6.
Hepatology (Baltimore, Md.) Jan, 2012 | Pubmed ID: 21887698
Experimental neurology Jan, 2012 | Pubmed ID: 22119622
Mechanistic insights into LDL nanoparticle-mediated siRNA delivery.
Bioconjugate chemistry Jan, 2012 | Pubmed ID: 22142191
RNA (New York, N.Y.) Mar, 2012 | Pubmed ID: 22294662
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.
Nature nanotechnology , 2012 | Pubmed ID: 22659608
Angewandte Chemie (International ed. in English) Jul, 2012 | Pubmed ID: 22782619
ABOUT JoVE
Copyright © 2025 MyJoVE Corporation. All rights reserved