Peter Vandenabeele

An outline of necrosome triggers.

An evolutionary perspective on the necroptotic pathway.

Initiation and execution mechanisms of necroptosis: an overview.

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.

Necroptosis: (Last) Message in a Bubble.

Necroptotic cell death in anti-cancer therapy.

RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680).

RIPK4 activity in keratinocytes is controlled by the SCF ubiquitin ligase to maintain cortical actin organization.

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.

Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis.

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes.

Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis.

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration.

Therapeutic Targeting of Connexin Channels: New Views and Challenges.

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis.

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps.

Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB.

The molecular machinery of regulated cell death.

Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells.

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock.

Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection.

TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice.

Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs.

Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex.

Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death.

Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins.

MLKL in cancer: more than a necroptosis regulator.

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL.

Patients with COVID-19: in the dark-NETs of neutrophils.

Plasma membrane permeabilization following cell death: many ways to dye!

Microbes exploit death-induced nutrient release by gut epithelial cells.

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.

RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury.

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis.

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state.

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death.

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies.

MLKL deficiency in BrafPten melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice.

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity.

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.

Spectrally Tunable Förster Resonance Energy Transfer-Based Biosensors Using Organic Dye Grafting.