Philip D. Compton

Departments of Chemistry and Molecular Biosciences,
Chemistry of Life Processes Institute,
Proteomics Center of Excellence,
Robert H. Lurie Comprehensive Cancer Center,
Departments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Proteomics Center of Excellence, Robert H. Lurie Comprehensive Cancer Center

Northwestern University

BIOGRAPHY

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PUBLICATIONS

Methods for analyzing peptides and proteins on a chromatographic timescale by electron-transfer dissociation mass spectrometry.

Nature protocols , 2008 | Pubmed ID: 18927556

Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis.

Science signaling , 2010 | Pubmed ID: 20068230

On the scalability and requirements of whole protein mass spectrometry.

Analytical chemistry Sep, 2011 | Pubmed ID: 21744800

Mapping intact protein isoforms in discovery mode using top-down proteomics.

Nature Dec, 2011 | Pubmed ID: 22037311

Optimization of electron transfer dissociation via informed selection of reagents and operating parameters.

Analytical chemistry Feb, 2012 | Pubmed ID: 22182179

Evaluation of the compact high-field orbitrap for top-down proteomics of human cells.

Journal of proteome research Aug, 2012 | Pubmed ID: 22746247

Spinning up mass spectrometry for whole protein complexes.

Nature methods Nov, 2012 | Pubmed ID: 23132117

Top down proteomics of human membrane proteins from enriched mitochondrial fractions.

Analytical chemistry Feb, 2013 | Pubmed ID: 23305238

Front-end electron transfer dissociation: a new ionization source.

Analytical chemistry Sep, 2013 | Pubmed ID: 23909443

From protein complexes to subunit backbone fragments: a multi-stage approach to native mass spectrometry.

Analytical chemistry Dec, 2013 | Pubmed ID: 24237199

Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins.

Analytical chemistry Feb, 2014 | Pubmed ID: 24400813

Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins.

Proteomics May, 2014 | Pubmed ID: 24596178

Fragmentation of integral membrane proteins in the gas phase.

Analytical chemistry May, 2014 | Pubmed ID: 24689519

Deep and quantitative top-down proteomics in clinical and translational research.

Expert review of proteomics Dec, 2014 | Pubmed ID: 25347991

Native GELFrEE: a new separation technique for biomolecular assemblies.

Analytical chemistry Mar, 2015 | Pubmed ID: 25664979

Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry.

Journal of proteome research May, 2015 | Pubmed ID: 25836738

Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry.

Journal of proteomics May, 2015 | Pubmed ID: 25952688

Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.

Molecular & cellular proteomics : MCP Aug, 2015 | Pubmed ID: 26272979

Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts.

Molecular & cellular proteomics : MCP Jan, 2016 | Pubmed ID: 26503891

Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry.

International journal of mass spectrometry Nov, 2015 | Pubmed ID: 26692813

Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics.

EuPA open proteomics Sep, 2015 | Pubmed ID: 26753126

An informatic framework for decoding protein complexes by top-down mass spectrometry.

Nature methods Jan, 2016 | Pubmed ID: 26780093

INSTITUTIONS

Northwestern University

JOVE ARTICLES

CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis

Rafael D. Melani^*,1,2,

Henrique S. Seckler^*,1,

Owen S. Skinner¹,

Luis H. F. Do Vale^1,3,

Adam D. Catherman¹,

Pierre C. Havugimana¹,

Marcelo Valle de Sousa³,

Gilberto B. Domont²,

Neil L. Kelleher¹,

Philip D. Compton¹

¹Departments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Proteomics Center of Excellence, Robert H. Lurie Comprehensive Cancer Center, Northwestern University,

²Institute of Chemistry, Proteomics Unit, Federal University of Rio de Janeiro,

³Department of Cell Biology, Brazilian Center for Protein Research, Laboratory of Biochemistry and Protein Chemistry, University of Brasilia

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