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Department of Cell Biology and Physiology
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Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation.
The Journal of biological chemistry Jun, 2003 | Pubmed ID: 12663673
Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection.
The Journal of biological chemistry Nov, 2003 | Pubmed ID: 12933795
The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species.
Molecular and cellular neurosciences Jan, 2005 | Pubmed ID: 15607951
Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations.
The Journal of biological chemistry Mar, 2005 | Pubmed ID: 15632159
A transmembrane form of the prion protein is localized in the Golgi apparatus of neurons.
The Journal of biological chemistry Apr, 2005 | Pubmed ID: 15671025
Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2005 | Pubmed ID: 15800202
A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.
The Journal of biological chemistry Mar, 2010 | Pubmed ID: 19940127
"Late" macroendosomes and acidic endosomes in vertebrate motor nerve terminals.
The Journal of comparative neurology Dec, 2012 | Pubmed ID: 22740045
Washington University School of Medicine
Richard S. Stewart1,
Ilona M. Kiss1,
Robert S. Wilkinson1
1Department of Cell Biology and Physiology, Washington University School of Medicine
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