Robrecht Raedt

Neurostimulation for refractory epilepsy.

Chronic levetiracetam treatment early in life decreases epileptiform events in young GAERS, but does not prevent the expression of spike and wave discharges during adulthood.

Cell therapy for neurological disorders: a comprehensive review.

Rapid kindling in preclinical anti-epileptic drug development: the effect of levetiracetam.

Neuromodulation with levetiracetam and vagus nerve stimulation in experimental animal models of epilepsy.

Differentiation assays of bone marrow-derived Multipotent Adult Progenitor Cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers.

High frequency deep brain stimulation in the hippocampus modifies seizure characteristics in kindled rats.

Radiation of the rat brain suppresses seizure-induced neurogenesis and transiently enhances excitability during kindling acquisition.

Cell therapy in models for temporal lobe epilepsy.

A pilot trial with modified Atkins' diet in adult patients with refractory epilepsy.

Electrical stimulation for the treatment of epilepsy.

Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat.

Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy.

Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus.

Predictive factors for outcome of invasive video-EEG monitoring and subsequent resective surgery in patients with refractory epilepsy.

Comparison of hippocampal Deep Brain Stimulation with high (130Hz) and low frequency (5Hz) on afterdischarges in kindled rats.

Hippocampal deep brain stimulation induces decreased rCBF in the hippocampal formation of the rat.

Quantitative analysis of adenosine using liquid chromatography/atmospheric pressure chemical ionization-tandem mass spectrometry (LC/APCI-MS/MS).

Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery.

Evolution in VNS therapy for refractory epilepsy, experience with Demipulse devices at Ghent University Hospital.

Vagus nerve stimulation and the postictal state.

Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures.

Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation.

A novel implantable vagus nerve stimulation system (ADNS-300) for combined stimulation and recording of the vagus nerve: pilot trial at Ghent University Hospital.

Magnetoencephalography in epilepsy patients carrying a vagus nerve stimulator.

Antiepileptic drugs modulate P-glycoproteins in the brain: a mice study with (11)C-desmethylloperamide.

Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model.

Repeated assessment of larynx compound muscle action potentials using a self-sizing cuff electrode around the vagus nerve in experimental rats.

Automatic detection of epileptic seizures on the intra-cranial electroencephalogram of rats using reservoir computing.

Real-time detection of epileptic seizures in animal models using reservoir computing.

Innovative treatments for epilepsy: radiosurgery and local delivery.

Ictal-onset localization through connectivity analysis of intracranial EEG signals in patients with refractory epilepsy.

Electrophysiological responses from vagus nerve stimulation in rats.

Non-pharmacological treatment options for refractory epilepsy: an overview of human treatment modalities and their potential utility in dogs.

The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats.

Regional brain perfusion changes during standard and microburst vagus nerve stimulation in dogs.

The P3 event-related potential is a biomarker for the efficacy of vagus nerve stimulation in patients with epilepsy.

Vagus nerve stimulation…25 years later! What do we know about the effects on cognition?

Evaluation of heart rate variability in dogs during standard and microburst vagus nerve stimulation: a pilot study.

Hippocampal deep brain stimulation reduces glucose utilization in the healthy rat brain.

The effect of vagus nerve stimulation on CSF monoamines and the PTZ seizure threshold in dogs.

Vagus nerve stimulation has antidepressant effects in the kainic acid model for temporal lobe epilepsy.

Event-related potentials reveal preserved attention allocation but impaired emotion regulation in patients with epilepsy and comorbid negative affect.

Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors.

Subthalamic nucleus stimulation and spontaneous language production in Parkinson's disease: A double laterality problem.

The antidepressant mechanism of action of vagus nerve stimulation: Evidence from preclinical studies.

Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain.

The antidepressant-like effect of vagus nerve stimulation is mediated through the locus coeruleus.

The systemic kainic acid rat model of temporal lobe epilepsy: Long-term EEG monitoring.

Modulation of Hippocampal Activity by Vagus Nerve Stimulation in Freely Moving Rats.

A Preclinical Study of Laryngeal Motor-Evoked Potentials as a Marker Vagus Nerve Activation.

Responsive neurostimulation in epilepsy.

Vagus Nerve Stimulator Placement in Dogs: Surgical Implantation Technique, Complications, Long-Term Follow-Up, and Practical Considerations.

Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures.

Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle.

Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice.

Repetitive transcranial magnetic stimulation for the treatment of refractory epilepsy.

EEG Derived Brain Activity Reflects Treatment Response from Vagus Nerve Stimulation in Patients with Epilepsy.

The effect of vagus nerve stimulation on response inhibition.

Clinical Vagus Nerve Stimulation Paradigms Induce Pronounced Brain and Body Hypothermia in Rats.

Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy.

Reduced distractor interference during vagus nerve stimulation.

Recent advances in devices for vagus nerve stimulation.

The validation of Short Interspersed Nuclear Elements (SINEs) as a RT-qPCR normalization strategy in a rodent model for temporal lobe epilepsy.

Hypothermia Masks Most of the Effects of Rapid Cycling VNS on Rat Hippocampal Electrophysiology.

Preparing for hard times: Scalp and intracranial physiological signatures of proactive cognitive control.

Alterations in the functional brain network in a rat model of epileptogenesis: A longitudinal resting state fMRI study.

Vagus Nerve Stimulation-Induced Laryngeal Motor Evoked Potentials: A Possible Biomarker of Effective Nerve Activation.

Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy.

2-[F]FELP, a novel LAT1-specific PET tracer, for the discrimination between glioblastoma, radiation necrosis and inflammation.

Kainic acid-induced status epilepticus decreases mGlu receptor and phase-specifically downregulates Homer1b/c expression.

Dynamic functional connectivity and graph theory metrics in a rat model of temporal lobe epilepsy reveal a preference for brain states with a lower functional connectivity, segregation and integration.

A Feasibility Study to Investigate Chemogenetic Modulation of the Locus Coeruleus by Means of Single Unit Activity.

Deep brain stimulation reduces evoked potentials with a dual time course in freely moving rats: Potential neurophysiological basis for intermittent as an alternative to continuous stimulation.

Transcutaneous Vagus Nerve Stimulation Does Not Affect Verbal Memory Performance in Healthy Volunteers.

Identification of vagus nerve stimulation parameters affecting rat hippocampal electrophysiology without temperature effects.

Acute symptomatic seizures following intracerebral hemorrhage in the rat collagenase model.

Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice.

Development of a Rat Model for Glioma-Related Epilepsy.

Spontaneous Right Ventricular Pseudoaneurysms and Increased Arrhythmogenicity in a Mouse Model of Marfan Syndrome.

Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain.

The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A Receptor.

Long-term chemogenetic suppression of seizures in a multifocal rat model of temporal lobe epilepsy.

Pre-ictal heart rate variability alterations in focal onset seizures and response to vagus nerve stimulation.

Hippocampal Sclerosis in Frontotemporal Dementia: When Vascular Pathology Meets Neurodegeneration.

Attenuation of Hippocampal Evoked Potentials by Activation of GtACR2, an Optogenetic Chloride Channel.

Optimized Parameters for Transducing the Locus Coeruleus Using Canine Adenovirus Type 2 (CAV2) Vector in Rats for Chemogenetic Modulation Research.

White Matter Integrity in a Rat Model of Epileptogenesis: Structural Connectomics and Fixel-Based Analysis.

Seizures and Interictal Epileptiform Activity in the Rat Collagenase Model for Intracerebral Hemorrhage.

Double Two-State Opsin Model With Autonomous Parameter Inference.

Investigating the Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Cortical Excitability in Healthy Males.

Comparison of In Vivo and Ex Vivo Magnetic Resonance Imaging in a Rat Model for Glioblastoma-Associated Epilepsy.

Level of hM4D(Gi) DREADD Expression Determines Inhibitory and Neurotoxic Effects in the Hippocampus.

Voxel-Based Analysis of [18F]-FDG Brain PET in Rats Using Data-Driven Normalization.

Chemogenetic Seizure Control with Clozapine and the Novel Ligand JHU37160 Outperforms the Effects of Levetiracetam in the Intrahippocampal Kainic Acid Mouse Model.

blue light illumination for optogenetic inhibition: effect on local temperature and excitability of the rat hippocampus.

Transcutaneous auricular vagus nerve stimulation cannot modulate the P3b event-related potential in healthy volunteers.

The potential of invasive and non-invasive vagus nerve stimulation to improve verbal memory performance in epilepsy patients.

Laryngeal Muscle-Evoked Potential Recording as an Indicator of Vagal Nerve Fiber Activation.