Thomas C. Irving

Synchrotron X-ray imaging reveals a correlation of tumor copper speciation with Clioquinol's anticancer activity.

Myosin head configuration in relaxed insect flight muscle: x-ray modeled resting cross-bridges in a pre-powerstroke state are poised for actin binding.

Microfibrillar structure of type I collagen in situ.

Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae.

Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila.

Structure of flexible filamentous plant viruses.

X-ray scattering study of actin polymerization nuclei assembled by tandem W domains.

Cost-effective EMCCD-based detector for time-resolved biological SAXS applications.

High-flux hard X-ray microbeam using a single-bounce capillary with doubly focused undulator beam.

Alternative S2 hinge regions of the myosin rod affect myofibrillar structure and myosin kinetics.

Phosphorylation and the N-terminal extension of the regulatory light chain help orient and align the myosin heads in Drosophila flight muscle.

Myofilament length dependent activation.

X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle.

Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity.

Myosin head orientation: a structural determinant for the Frank-Starling relationship.

Regulatory light chain phosphorylation and N-terminal extension increase cross-bridge binding and power output in Drosophila at in vivo myofilament lattice spacing.

COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle.

Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction.

Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime.

Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.

Thick-to-thin filament surface distance modulates cross-bridge kinetics in Drosophila flight muscle.

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.

Head-head interactions of resting myosin crossbridges in intact frog skeletal muscles, revealed by synchrotron x-ray fiber diffraction.

The length-tension curve in muscle depends on lattice spacing.

Advances in turbulent mixing techniques to study microsecond protein folding reactions.

Sub-millisecond time-resolved SAXS using a continuous-flow mixer and X-ray microbeam.

High-speed detector for time-resolved diffraction studies.

Microsecond barrier-limited chain collapse observed by time-resolved FRET and SAXS.

Modulation of frustration in folding by sequence permutation.

Hugh E. Huxley: the compleat biophysicist.

Elastic proteins in the flight muscle of Manduca sexta.

Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.

Methods for analysis of size-exclusion chromatography-small-angle X-ray scattering and reconstruction of protein scattering.

Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.

X-ray diffraction from nonuniformly stretched helical molecules.

Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C.

Three-dimensional stochastic model of actin-myosin binding in the sarcomere lattice.

Atomistic modelling of scattering data in the Collaborative Computational Project for Small Angle Scattering (CCP-SAS).

Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice.

Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors.

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3).

Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified mice.

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.

Structural and functional impact of troponin C-mediated Ca sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle.

Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle.

Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle.

Thick-Filament Extensibility in Intact Skeletal Muscle.

Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.

Getting into the thick (and thin) of it.

Response to: Thick Filament Length Changes in Muscle Have Both Elastic and Structural Components.

Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity.

Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin.