Centre for Addiction and Mental Health (CAMH)
Dr. Thomas Prevot is a Project Scientist, and Project Lead of the Drug Development Program within the Neurobiology of Depression and Aging Department of CAMH. Dr. Prevot received his PhD in Behavioral Neuropsychopharmacology from the University of Bordeaux in France in 2015, and did his postdoctoral fellowship in CAMH from 2016 to 2019. He is also an alumni of the EUREKA Institute for Translational Medicine.
Dr. Prevot’s research focuses on the neurobiology of stress, aging, and their interactions, and on understanding how stress and aging impact quality of life and lead to psychiatric and neurodegenerative diseases. He is the program manager of a drug development program working with Dr. Etienne Sibille. As an ethologist and a behavioural pharmacologist, he has developed unique expertise in the field of translational research, including the characterization of novel targets for therapeutic avenues and medication development for future clinical testing. Dr. Prevot is actively involved in the translational research and medicine landscape at the University of Toronto, working across disciplines and being an advocate for bench-to-bedside discovery.
Dr. Prevot also has a keen interest at improving animal welfare in laboratory settings and developed handling techniques to reduce stress in mice.
Increased Neuronal DNA/RNA Oxidation in the Frontal Cortex of Mice Subjected to Unpredictable Chronic Mild Stress.
Chronic stress (Thousand Oaks, Calif.) Jan-Dec, 2017 | Pubmed ID: 29250610
Shifting priorities: highly conserved behavioral and brain network adaptations to chronic stress across species.
Translational psychiatry 01, 2018 | Pubmed ID: 29353879
The Relative Contributions of Cell-Dependent Cortical Microcircuit Aging to Cognition and Anxiety.
Biological psychiatry 02, 2019 | Pubmed ID: 30446205
Insight into Novel Treatment for Cognitive Dysfunctions across Disorders.
ACS chemical neuroscience May, 2019 | Pubmed ID: 30920790
Residual avoidance: A new, consistent and repeatable readout of chronic stress-induced conflict anxiety reversible by antidepressant treatment.
Neuropharmacology 07, 2019 | Pubmed ID: 31075295
Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles.
Molecular neuropsychiatry Apr, 2019 | Pubmed ID: 31192221
Median raphe serotonin neurons promote anxiety-like behavior via inputs to the dorsal hippocampus.
Neuropharmacology May, 2020 | Pubmed ID: 32035145
Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders.
Molecular psychiatry 01, 2021 | Pubmed ID: 32346158
Chronic Stress-induced Behaviors Correlate with Exacerbated Acute Stress-induced Cingulate Cortex and Ventral Hippocampus Activation.
Neuroscience 08, 2020 | Pubmed ID: 32473277
Synthesis of chiral GABA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression.
ARKIVOC : free online journal of organic chemistry , 2018 | Pubmed ID: 32774192
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.
Cerebral cortex (New York, N.Y. : 1991) Jan, 2021 | Pubmed ID: 33068001
Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation.
The international journal of neuropsychopharmacology Jul, 2021 | Pubmed ID: 33438026
Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density.
Neuropharmacology Jun, 2021 | Pubmed ID: 33864799
Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex.
The international journal of neuropsychopharmacology Oct, 2021 | Pubmed ID: 34346493
Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits.
Cell reports Jan, 2022 | Pubmed ID: 35021088
Symptomatic and neurotrophic effects of GABAA receptor positive allosteric modulation in a mouse model of chronic stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Aug, 2022 | Pubmed ID: 35701547
Positive Allosteric Modulation of α5-GABAA Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle.
The international journal of neuropsychopharmacology Aug, 2022 | Pubmed ID: 35732272
Neurotrophic effects of potentiating gaba-mediated dendritic inhibition.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Jan, 2023 | Pubmed ID: 35995974
Hippocampal α5-GABA Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area.
Biological psychiatry global open science Jan, 2023 | Pubmed ID: 36712569
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