A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

In recent years, the incidence of thyroid cancer has been increasing. Thyroid nodule detection is critical for both the detection and treatment of thyroid ...

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

The manuscript describes the transoral endoscopic thyroidectomy vestibular approach (TOETVA) for thyroid lobectomy. The patient is placed in the supine ...

West China Hospital of Sichuan University

Sichuan University West China Hospital

&#x672C;&#x7814;&#x7A76;&#x7684;&#x76EE;&#x7684;&#x662F;&#x8BC4;&#x4F30;&#x662F;&#x5426; 2-fluoro[fluorine-18]-2-deoxy-D&#xFF1A;-&#x8461;&#x8404;&#x7CD6; (F 18 &#x4E34;&#x5E8A;&#x4EF7;&#x503C;) &#x6B63;&#x7535;&#x5B50;&#x53D1;&#x5C04;&#x65AD;&#x5C42;&#x626B;&#x63CF; (PET) &#x53EF;&#x4EE5;&#x533A;&#x5206;&#x6076;&#x6027;&#x4E0E;&#x826F;&#x6027;&#x9AA8;&#x75C5;&#x53D8;&#x548C;&#x662F;&#x5426;&#x83B7;&#x5F97;&#x5EF6;&#x8FDF; F-18 PET &#x56FE;&#x50CF;&#x53EF;&#x4EE5;&#x6539;&#x8FDB;&#x6280;&#x672F;&#x7684;&#x51C6;&#x786E;&#x6027;&#x3002;

&#x53CC;&#x65F6;&#x95F4;&#x70B9; PET/CT &#x4E0E; F-18 &#x4E34;&#x5E8A;&#x4EF7;&#x503C;&#x4E3A;&#x5206;&#x5316;&#x7684;&#x6076;&#x6027;&#x548C;&#x826F;&#x6027;&#x9AA8;&#x7684;&#x75C5;&#x53D8;&#x3002;

The purpose of the present study was to evaluate whether 2-fluoro[fluorine-18]-2-deoxy-D: -glucose (F-18 FDG) positron emission tomography (PET) could differentiate malignant and benign bone lesions and whether obtaining delayed F-18 FDG PET images could improve the accuracy of the technique.

Dual-time point PET/CT with F-18 FDG for the differentiation of malignant and benign bone lesions.

Le but de la pr&#xE9;sente &#xE9;tude &#xE9;tait d&#x26;#39;&#xE9;valuer si le 2-fluoro [fluor-18]-2-d&#xE9;soxy-D:-glucose (F-18 FDG) par &#xE9;mission de positons (TEP) pourrait diff&#xE9;rencier les l&#xE9;sions osseuses malignes et b&#xE9;nignes, et si l&#x26;#39;obtention retard&#xE9;e F-18 FDG PET images pourrait am&#xE9;liorer la pr&#xE9;cision de la technique.

Dual-time point PET / CT avec F-18 FDG pour la diff&#xE9;renciation des l&#xE9;sions osseuses malignes et b&#xE9;nignes

Der Zweck der vorliegenden Studie war, ob 2-fluoro[fluorine-18]-2-deoxy-D zu bewerten:-Glukose (F-18 FDG)-Positronen-Emissions-Tomographie (PET) k&ouml;nnten differenzieren maligne und benigne Knochenl&auml;sionen und ob F-18-FDG-PET-Bilder Erlangung verz&ouml;gert konnte die Genauigkeit der Technik zu verbessern.

Dual-Time Punkt PET/CT mit F-18 FDG f&uuml;r die Differenzierung von malignen und benignen Knochenl&auml;sionen.

Dysfunctional signaling of the PI3K/AKT/mTOR pathway in cancer and its crucial role in cell growth and survival have made it a much desired target for cancer therapeutics. A series of dimorpholine substituted thienopyrimidine derivatives had been prepared and evaluated in vitro and in vivo. Among them, compound 14o was identified as a dual Class I PI3K and mTOR kinase inhibitor, which had an approximately 8-fold improvement in mTOR inhibition relative to the class I PI3K inhibitor 1 (pictilisib, GDC-0941). Western blot analysis confirmed the 14o mechanistic modulation of the cellular PI3K/AKT/mTOR pathway through inhibiting phosphorylation of both AKT and S6 in human cancer cell lines. In addition, 14o demonstrated significant efficacy in SKOV-3 and U87MG tumor xenograft models without causing significant weight loss and toxicity.

Design, Synthesis, and Biological Evaluation of Dimorpholine Substituted Thienopyrimidines as Potential Class I PI3K/mTOR Dual Inhibitors.

We focus on providing the first comprehensive national dataset on the incidence, injury aetiology and mortality of TSCI in China.

Trends of epidemiological characteristics of traumatic spinal cord injury in China, 2009-2018.

The increasing burden of non-alcoholic fatty liver disease (NAFLD) worldwide imposes an emerging public health issue. We perform the current study to estimate the global prevalence, incidence, disease progression, and clinical outcomes of NAFLD.

Estimating global prevalence, incidence, and outcomes of non-alcoholic fatty liver disease from 2000 to 2021: systematic review and meta-analysis.

Objective: Observational studies have shown the association between iron status and osteoarthritis (OA). However, due to difficulties of determining sequential temporality, their causal association is still elusive. Based on the summary data of genome-wide association studies (GWASs) of a large-scale population, this study explored the genetic causal association between iron status and OA. Methods: First, we took a series of quality control steps to select eligible instrumental SNPs which were strongly associated with exposure. The genetic causal association between iron status and OA was analyzed using the two-sample Mendelian randomization (MR). Inverse-variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods were used for analysis. The results were mainly based on IVW (random effects), followed by sensitivity analysis. IVW and MR-Egger were used for heterogeneity testing. MR-Egger was also used for pleiotropy testing. Leave-one-SNP-out analysis was used to identify single nucleotide polymorphisms (SNPs) with potential impact. Maximum likelihood, penalized weighted median, and IVW (fixed effects) were performed to further validate the reliability of results. Results: IVW results showed that transferrin saturation had a positive causal association with knee osteoarthritis (KOA), hip osteoarthritis (HOA) and KOA or HOA (p < 0.05, OR > 1), and there was a negative causal association between transferrin and HOA and KOA or HOA (p < 0.05, OR < 1). The results of heterogeneity test showed that our IVW analysis results were basically free of heterogeneity (p > 0.05). The results of the pleiotropy test showed that there was no pleiotropy in our IVW analysis (p > 0.05). The analysis results of maximum likelihood, penalized weighted median and IVW (fixed effects) were consistent with our IVW results. No genetic causal association was found between serum iron and ferritin and OA. Conclusions: This study provides evidence of the causal association between iron status and OA, which provides novel insights to the genetic research of OA.

Ye Tian

Department of Ultrasonography

West China Hospital of Sichuan University

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Ye Tian

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Ultrasonography

West China Hospital of Sichuan University

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Department of Ultrasonography