Zigang Li

A virus-like particle of the hepatitis B virus preS antigen elicits robust neutralizing antibodies and T cell responses in mice.

Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2.

Solution-processed photodetectors based on organic-inorganic hybrid perovskite and nanocrystalline graphite.

E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes.

An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide.

A Thioether-Stabilized d-Proline-l-Proline-Induced β-Hairpin Peptide of Defensin Segment Increases Its Anti-Candida albicans Ability.

A proline-derived transannular N-cap for nucleation of short α-helical peptides.

Constructing thioether-tethered cyclic peptides via on-resin intra-molecular thiol-ene reaction.

An in-tether sulfilimine chiral center induces helicity in short peptides.

Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus.

Crosslinked Aspartic Acids as Helix-Nucleating Templates.

An in-tether sulfilimine chiral center induces β-turn conformation in short peptides.

An in-tether sulfoxide chiral center influences the biophysical properties of the N-capped peptides.

Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids.

Switching substitution groups on the in-tether chiral centre influences backbone peptides' permeability and target binding affinity.

Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.

SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer.

Dual In-Tether Chiral Centers Modulate Peptide Helicity.

A precisely positioned chiral center in an i, i + 7 tether modulates the helicity of the backbone peptide.

Reversible and Versatile On-Tether Modification of Chiral-Center-Induced Helical Peptides.

Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: A Comparative Study.

An in-tether chiral center modulates the proapoptotic activity of the KLA peptide.

Development of a high quantum yield dye for tumour imaging.

High-Throughput Screening Strategies for the Development of Anti-Virulence Inhibitors Against Staphylococcus Aureus.

N terminal N-methylation modulates chiral centre induced helical (CIH) peptides' biophysical properties.

Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning.

Autophosphorylation Mechanism of the Ser/Thr Kinase Stk1 From .

Tuning peptide self-assembly by an in-tether chiral center.

Reversible stapling of unprotected peptides chemoselective methionine bis-alkylation/dealkylation.

Evaluation of topologically distinct constrained antimicrobial peptides with broad-spectrum antimicrobial activity.

Recent advances in peptidomimetics antagonists targeting estrogen receptor α-coactivator interaction in cancer therapy.

Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells .

Autophagy inducing cyclic peptides constructed by methionine alkylation.

Design and Synthetic Strategies for Helical Peptides.

A sulfonium tethered peptide ligand rapidly and selectively modifies protein cysteine in vicinity.

α-Helical Motif as Inhibitors of Toxic Amyloid-β Oligomer Generation via Highly Specific Recognition of Amyloid Surface.

Uncariitannin, a polyphenolic polymer from Uncaria gambier, attenuates Staphylococcus aureus virulence through an MgrA-mediated regulation of α-hemolysin.

Directional assembly of a stapled α-helical peptide.

Targeting the Amyloid-β Fibril Surface with a Constrained Helical Peptide Inhibitor.

A Sulfonium Triggered Thiol-yne Reaction for Cysteine Modification.

Intramolecular methionine alkylation constructs sulfonium tethered peptides for protein conjugation.

Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension.

Organosilicon modification to enhance the stability of black phosphorus nanosheets under ambient conditions.

Dual-acidity-labile polysaccharide-di-drugs conjugate for targeted cancer chemotherapy.

An overview of the safety, clinical application and antiviral research of the COVID-19 therapeutics.

Structural insights into the inhibition of bacterial RecA by naphthalene polysulfonated compounds.

Molecular design of stapled pentapeptides as building blocks of self-assembled coiled coil-like fibers.

SOD1 is a Possible Predictor of COVID-19 Progression as Revealed by Plasma Proteomics.

Facile Chemoselective Modification of Thioethers Generates Chiral Center-Induced Helical Peptides.

Potent Inhibition of HIF1α and p300 Interaction by a Constrained Peptide Derived from CITED2.

Helical Stabilization of Peptide Macrocycles by Stapled Architectures.

Novel Strategies in C-H Oxidations for Natural Product Diversification-A Remote Functionalization Application Summary.

Tetrahedral DNA nanostructure based biosensor for high-performance detection of circulating tumor DNA using all-carbon nanotube transistor.

Electrophilic Sulfonium-Promoted Peptide and Protein Amidation in Aqueous Media.

Design and Evaluation of a Novel Peptide-Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease.

Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30.

Sulfonium Triggered Alkyne-Azide Click Cycloaddition.

Chemo-Selective Cys-Pen Disulfide for Proximity-Induced Cysteine Cross-Linking.

Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells.

A novel inhibitor of -methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities.

Computational elucidation of the binding mechanisms of curcumin analogues as bacterial RecA inhibitors.

Whole-body PET tracking of a d-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors.

Flavin catalyzed desulfurization of peptides and proteins in aqueous media.

Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization.

Therapeutic potential for amyloid surface inhibitor: only amyloid-β oligomers formed by secondary nucleation disrupt lipid membrane integrity.

Sulfonium-Tethered Peptide.

Histidine-specific bioconjugation visible-light-promoted thioacetal activation.

Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction.

Biodistribution, degradability and clearance of 2D materials for their biomedical applications.

Universal DNA detection realized by peptide based carbon nanotube biosensors.

A Peptide-Based Ligand-Directed Chemistry Enables Protein Functionalization.