Adam V. Kwiatkowski

Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration.

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference.

Function and regulation of Ena/VASP proteins.

Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.

Catenins: playing both sides of the synapse.

Ena/VASP Is Required for neuritogenesis in the developing cortex.

Ena/VASP is required for endothelial barrier function in vivo.

Filopodia are required for cortical neurite initiation.

Cell autonomous defects in cortical development revealed by two-color chimera analysis.

Rapid assembly of functional presynaptic boutons triggered by adhesive contacts.

AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion.

In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans.

Control of actin dynamics by allosteric regulation of actin binding proteins.

Danio rerio αE-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αE-catenin.

αE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors.

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.

A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion.

αT-Catenin Is a Constitutive Actin-binding α-Catenin That Directly Couples the Cadherin·Catenin Complex to Actin Filaments.

Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and F-actin.