Alberto Anel

Apo2L/TRAIL and immune regulation.

Protein kinase C-theta is required for NK cell activation and in vivo control of tumor progression.

Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors.

All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity.

Liposome-bound TRAIL induces superior DR5 clustering and enhanced DISC recruitment in histiocytic lymphoma U937 cells.

MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells.

Human NK cells activated by EBV(+) lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells.

IFNα signaling through PKC-θ is essential for antitumor NK cell function.

Second meeting of the Spanish Immunotherapy Group GEIT (Grupo Español de Inmunoterapia), January 16, 2015, in Zaragoza, Spain.

potential of recombinant granulysin against human tumors.

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Activated Allogeneic NK Cells Preferentially Kill Poor Prognosis B-Cell Chronic Lymphocytic Leukemia Cells.

Mitochondrial Complex I activity signals antioxidant response through ERK5.

Lipid Nanoparticles Decorated with TNF-Related Aptosis-Inducing Ligand (TRAIL) Are More Cytotoxic than Soluble Recombinant TRAIL in Sarcoma.

Expansion of allogeneic NK cells with efficient antibody-dependent cell cytotoxicity against multiple tumors.

Role of Exosomes in the Regulation of T-cell Mediated Immune Responses and in Autoimmune Disease.

Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy.

Immunogenic Cell Death and Immunotherapy of Multiple Myeloma.

Mutations in the Subunit of Mitochondrial Complex I Are Sufficient to Confer Increased Tumorigenic and Metastatic Potential to Cancer Cells.

Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin.

Response: Commentary: Immunogenic Cell Death and Immunotherapy of Multiple Myeloma.

Novel Forms of Immunomodulation for Cancer Therapy.

Editorial: The Natural Killer Cell Interactome in the Tumor Microenvironment: Basic Concepts and Clinical Application.

Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology.

Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance.

Immunologic evaluation and genetic defects of apoptosis in patients with autoimmune lymphoproliferative syndrome (ALPS).

Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients.

In vivo potential of recombinant granulysin against human melanoma.

Future prospects for mitosis-targeted antitumor therapies.

Antibody-Based Immunotoxins for Colorectal Cancer Therapy.

Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1).

Harnessing the Potential of NK Cell-Based Immunotherapies against Multiple Myeloma.

The metabolism of cells regulates their sensitivity to NK cells depending on p53 status.

Cytokine Profile and Anti-Inflammatory Activity of a Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells (PRS CK STORM).

Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells).

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment.

Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity.

PT-112 Induces Mitochondrial Stress and Immunogenic Cell Death, Targeting Tumor Cells with Mitochondrial Deficiencies.

Ecto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosis.

DR5 Up-Regulation Induced by Dichloroacetate Sensitizes Tumor Cells to Lipid Nanoparticles Decorated with TRAIL.

Study of the Bcl-2 Interactome by BiFC Reveals Differences in the Activation Mechanism of Bax and Bak.