Department of Clinical Infection Microbiology & Immunology,
Institute of Infection & Global Health,
Department of Clinical Infection Microbiology & Immunology, Institute of Infection & Global Health
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Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection.
Infection and immunity Mar, 2002 | Pubmed ID: 11854243
Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type.
Infection and immunity Jun, 2002 | Pubmed ID: 12010976
Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin.
Infection and immunity Apr, 2003 | Pubmed ID: 12654795
The MicAB two-component signaling system is involved in virulence of Streptococcus pneumoniae.
Infection and immunity Nov, 2003 | Pubmed ID: 14573696
Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils.
Infection and immunity Feb, 2004 | Pubmed ID: 14742512
The innate immune response to pneumococcal lung infection: the untold story.
Trends in immunology Mar, 2004 | Pubmed ID: 15036042
Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae.
Infection and immunity Apr, 2004 | Pubmed ID: 15039376
CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection.
Infection and immunity May, 2004 | Pubmed ID: 15102777
Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts.
Microbes and infection / Institut Pasteur May, 2005 | Pubmed ID: 15893495
Susceptibility and resistance to pneumococcal disease in mice.
Briefings in functional genomics & proteomics Nov, 2005 | Pubmed ID: 16420749
Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis.
Infection and immunity Jul, 2006 | Pubmed ID: 16790774
Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis.
Molecular microbiology Sep, 2006 | Pubmed ID: 16925554
The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2006 | Pubmed ID: 16951345
MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands.
Nucleic acids research Jul, 2007 | Pubmed ID: 17537813
The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae.
FEMS microbiology letters Jan, 2008 | Pubmed ID: 18053067
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease.
Nature reviews. Microbiology Apr, 2008 | Pubmed ID: 18340341
Increased TNF expression in CD43++ murine blood monocytes.
Immunology letters Jun, 2008 | Pubmed ID: 18468696
Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.
The Journal of infectious diseases May, 2009 | Pubmed ID: 19392624
Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae.
Journal of leukocyte biology Apr, 2010 | Pubmed ID: 20028774
The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.
Immunobiology Apr, 2010 | Pubmed ID: 20071053
Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14.
Infection and immunity Apr, 2010 | Pubmed ID: 20123716
Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2010 | Pubmed ID: 20483738
A subtype of a Pseudomonas aeruginosa cystic fibrosis epidemic strain exhibits enhanced virulence in a murine model of acute respiratory infection.
The Journal of infectious diseases Sep, 2010 | Pubmed ID: 20704484
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
PLoS pathogens , 2010 | Pubmed ID: 21085613
The integrins Mac-1 and alpha4beta1 perform crucial roles in neutrophil and T cell recruitment to lungs during Streptococcus pneumoniae infection.
Journal of immunology (Baltimore, Md. : 1950) May, 2011 | Pubmed ID: 21460207
Streptococcus pyogenes antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation.
Molecular microbiology Aug, 2011 | Pubmed ID: 21736640
Sex-based differences in susceptibility to respiratory and systemic pneumococcal disease in mice.
The Journal of infectious diseases Dec, 2011 | Pubmed ID: 22021621
Absence of the lectin activation pathway of complement does not increase susceptibility to Pseudomonas aeruginosa infections.
Immunobiology Feb, 2012 | Pubmed ID: 22070931
Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Mar, 2012 | Pubmed ID: 22238165
Capsule type of Streptococcus pneumoniae determines growth phenotype.
PLoS pathogens , 2012 | Pubmed ID: 22412375
P4-mediated antibody therapy in an acute model of invasive pneumococcal disease.
The Journal of infectious diseases May, 2012 | Pubmed ID: 22457294
T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice.
PLoS pathogens , 2012 | Pubmed ID: 22563306
Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug, 2012 | Pubmed ID: 22593545
Gene expression in fungi.
IMA fungus Jun, 2011 | Pubmed ID: 22679585
The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.
PLoS pathogens , 2012 | Pubmed ID: 22792067
Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B.
The Journal of allergy and clinical immunology Dec, 2012 | Pubmed ID: 23260752
Controlled Human Infection and Re-Challenge with Streptococcus Pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults.
American journal of respiratory and critical care medicine Jan, 2013 | Pubmed ID: 23370916
Jenna F. Gritzfeld1,
Angie D. Wright1,2,3,
Andrea M. Collins1,2,4,
Shaun H. Pennington1,
Adam K.A. Wright5,
Aras Kadioglu6,
Daniela M. Ferreira1,
Stephen B. Gordon1
1Respiratory Infection Group, Liverpool School of Tropical Medicine,
2Royal Liverpool and Broadgreen, University Hospital Trust,
3, Comprehensive Local Research Network,
4NIHR Biomedical Research Centre in Microbial Diseases, Royal Liverpool and Broadgreen University Hospitals NHS Trust,
5Institute of Lung Health, Respiratory Biomedical Unit, University Hospitals of Leicester NHS Trust & University of Leicester,
6Department of Clinical Infection Microbiology & Immunology, Institute of Infection & Global Health, University of Liverpool
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