Cynthia E. Dunbar

Retroviral transduction and engraftment ability of primate hematopoietic progenitor and stem cells transduced under serum-free versus serum-containing conditions.

Genetic marking as an approach to studying in vivo hematopoiesis: progress in the non-human primate model.

Plasticity and hematopoiesis: Circe's transforming potion?

Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene.

Absence of donor-derived keratinocyte stem cells in skin tissues cultured from patients after mobilized peripheral blood hematopoietic stem cell transplantation.

Polyclonal long-term repopulating stem cell clones in a primate model.

High-dose cyclophosphamide with autologous lymphocyte-depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia.

Retroviral transduction efficiency of G-CSF+SCF-mobilized peripheral blood CD34+ cells is superior to G-CSF or G-CSF+Flt3-L-mobilized cells in nonhuman primates.

Update on hematopoietic stem cell gene transfer using non-human primate models.

Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial.

Prolonged multilineage clonal hematopoiesis in a rhesus recipient of CD34 positive cells marked with a RD114 pseudotyped oncoretroviral vector.

Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells.

Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing.

Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells.

Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors.

Direct comparison of RD114-pseudotyped versus amphotropic-pseudotyped retroviral vectors for transduction of rhesus macaque long-term repopulating cells.

Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates.

Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system.

Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia.

In vivo gene marking of rhesus macaque long-term repopulating hematopoietic cells using a VSV-G pseudotyped versus amphotropic oncoretroviral vector.

The presence of the carboxy-terminal fragment of fibronectin allows maintenance of non-human primate long-term hematopoietic repopulating cells during extended ex vivo culture and transduction.

The impact of low-dose busulfan on clonal dynamics in nonhuman primates.

MRI detection of single particles for cellular imaging.

Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells.

Gene therapy for hematologic disease: Don't throw the baby out with the bathwater!

Genetic manipulation of hematopoietic stem cells.

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.

Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner.

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells.

Stem cell gene transfer: insights into integration and hematopoiesis from primate genetic marking studies.

Large granular lymphocytic proliferation-associated cyclic thrombocytopenia.

A new direction for gene therapy: intrathymic T cell-specific lentiviral gene transfer.

Hematopoietic stem cell gene therapy: dead or alive?

Resetting the immune system in immune thrombocytopenic purpura: immunoablative strategies.

Outcomes and risks of granulocyte colony-stimulating factor in patients with coronary artery disease.

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque.

Mobilization as a preparative regimen for hematopoietic stem cell transplantation.

AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates.

Anti-interleukin-2 receptor antibody (daclizumab) treatment of corticosteroid-refractory autoimmune thrombocytopenic purpura.

Combination therapy with rFVIIa and platelets for hemorrhage in patients with severe thrombocytopenia and alloimmunization.

In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques.

Genotoxicity of retroviral integration in hematopoietic cells.

Correction of the disease phenotype in canine leukocyte adhesion deficiency using ex vivo hematopoietic stem cell gene therapy.

Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates.

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.

Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.

Hematopoietic stem-cell behavior in nonhuman primates.

Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI.

No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells.

Transduction of rhesus macaque hematopoietic stem and progenitor cells with avian sarcoma and leukosis virus vectors.

Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing.

The yin and yang of stem cell gene therapy: insights into hematopoiesis, leukemogenesis, and gene therapy safety.

The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy.

HOXB4 and retroviral vectors: adding fuel to the fire.

Large animal models for stem and progenitor cell analysis.

Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population.

Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors.

Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer.

More frequent Blood transfusions.

'Ghostbusting' at blood.

Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche.

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells.

Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates.

Introducing "e-Blood".

In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.

Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate.

Keeping up with Blood: introducing our CME program.

Gene therapy activates EVI1, destabilizes chromosomes.

No evidence for clonal selection due to lentiviral integration sites in human induced pluripotent stem cells.

Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation.

Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers.

Contributions of gene marking to cell and gene therapies.

Patients, hematologists, and time.

CD9 up-regulation on CD34+ cells with ingenol 3,20-dibenzoate does not improve homing in NSG mice.

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.

Transient silencing of PTEN in human CD34(+) cells enhances their proliferative potential and ability to engraft immunodeficient mice.

Hematopoietic stem cell engineering at a crossroads.

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.

Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain.

Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B.

Eltrombopag and improved hematopoiesis in refractory aplastic anemia.

Thymidine kinase suicide gene-mediated ganciclovir ablation of autologous gene-modified rhesus hematopoiesis.

High efficiency restriction enzyme-free linear amplification-mediated polymerase chain reaction approach for tracking lentiviral integration sites does not abrogate retrieval bias.

Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by 5 fluorescent proteins using confocal and multiphoton microscopy.

Measurement of the absolute immature platelet number reflects marrow production and is not impacted by platelet transfusion.

BCL2A1a over-expression in murine hematopoietic stem and progenitor cells decreases apoptosis and results in hematopoietic transformation.

An educational infusion: more synergy between Blood and the American Society of Hematology.

Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells.

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs.

Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes.

No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model.

Hematopoietic stem cell gene therapy:assessing the relevance of preclinical models.

Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number.

Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug.

Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib.

Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study.

Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.

IFN-γ regulates survival and function of tumor-induced CD11b(+) Gr-1(high) myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.

Path to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model.