Eric Gouaux

Insights into transport mechanism from LeuT engineered to transport tryptophan.

A vibrational spectroscopic investigation of interactions of agonists with GluR0, a prokaryotic glutamate receptor.

Mechanism of glutamate receptor desensitization.

Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors.

Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate.

Beta-barrel membrane protein folding and structure viewed through the lens of alpha-hemolysin.

Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.

Vibrio cholerae cytolysin is composed of an alpha-hemolysin-like core.

Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity.

Arresting and releasing Staphylococcal alpha-hemolysin at intermediate stages of pore formation by engineered disulfide bonds.

Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes.

Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.

Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.

Structural basis for partial agonist action at ionotropic glutamate receptors.

Structural basis for modulation and agonist specificity of HCN pacemaker channels.

Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus.

Structure and function of AMPA receptors.

High resolution crystallographic studies of alpha-hemolysin-phospholipid complexes define heptamer-lipid head group interactions: implication for understanding protein-lipid interactions.

Structure of a glutamate transporter homologue from Pyrococcus horikoshii.

AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization.

Crystal structure of the Vibrio cholerae cytolysin (VCC) pro-toxin and its assembly into a heptameric transmembrane pore.

Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters.

Membrane proteins--pumping along.

Mechanism of positive allosteric modulators acting on AMPA receptors.

Subunit arrangement and function in NMDA receptors.

Principles of selective ion transport in channels and pumps.

Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins.

Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor.

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH.

Review. The molecular logic of sodium-coupled neurotransmitter transporters.

A competitive inhibitor traps LeuT in an open-to-out conformation.

Unlocking the molecular secrets of sodium-coupled transporters.

Crystal structure and association behaviour of the GluR2 amino-terminal domain.

Structure and mechanism of a Na+-independent amino acid transporter.

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state.

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.

The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins.

Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density.

Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.

Amino terminal domains of the NMDA receptor are organized as local heterodimers.

Principles of activation and permeation in an anion-selective Cys-loop receptor.

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states.

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context.

Molecular mechanism of ATP binding and ion channel activation in P2X receptors.

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue.

Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes.

A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening.

Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels.

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters.

Novel dicarboxylate selectivity in an insect glutamate transporter homolog.

X-ray structure of dopamine transporter elucidates antidepressant mechanism.

Structural basis for action by diverse antidepressants on biogenic amine transporters.

X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na(+)-selective channel.

NMDA receptor structures reveal subunit arrangement and pore architecture.

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.

Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies.

X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.

Neurotransmitter and psychostimulant recognition by the dopamine transporter.

Glycine receptor mechanism elucidated by electron cryo-microscopy.

Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation.

X-ray structures and mechanism of the human serotonin transporter.

Mechanism of NMDA Receptor Inhibition and Activation.

Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.

X-ray structures define human P2X3 receptor gating cycle and antagonist action.

Structure and symmetry inform gating principles of ionotropic glutamate receptors.

[4] Membrane protein crystallization: Application of sparse matrices to the α-hemolysin heptamer.