Modeling Posthemorrhagic Hydrocephalus of Prematurity in RatsShenandoah Robinson 1,2,3,4,5, Timothy Heck 3,4, Riddhi Patel 3,4, Balaji Vijayakumar 3,4, Hawley Helmbrecht 3,4, Yuma Kitase 3,4, Lauren L. Jantzie 1,2,3,4,5
1Division of Pediatric Neurosurgery, Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Neurology, Johns Hopkins University School of Medicine, 3Division of Neonatal-Perinatal Medicine, Johns Hopkins University School of Medicine, 4Neurosciences Intensive Care Nursery, Johns Hopkins Children's Center, 5Kennedy Krieger Institute
Posthemorrhagic hydrocephalus of prematurity (PHHP) can be modeled in neonatal rats by combining chorioamnionitis and intraventricular hemorrhage. The combination of these prenatal and postnatal events accurately recapitulates the clinical hallmarks of PHHP, including macrocephaly, ventriculomegaly, and elevated intracranial pressure, through the lifespan.
