Vetmeduni Vienna

1 ARTICLES PUBLISHED IN JoVE

Medicine

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System

Patrick M. Pilz¹, Miriam Lang¹, Ouafa Hamza¹, Petra L. Szabo¹, Milat Inci¹, Anne M. Kramer¹, Michael Koch², Johann Huber³, Bruno K. Podesser¹, Attila Kiss¹

¹Ludwig-Boltzmann-Institute for Cardiovascular Research at the Center for Biomedical Research, Medical University of Vienna, ²Concept & Ideation, Electrical Sector/EMEA/Power Distribution Division, Eaton Industries (Austria) GmbH, ³Vetfarm and Clinical Unit for Herd Health Management in Ruminants, Clinic for Ruminants, Vetmeduni Vienna

This article presents an efficient method to perform myocardial ischemia and subsequent chronic reperfusion in rats using a minimally invasive approach. In addition, left ventricular hemodynamic function of rats is assessed by echocardiography and isolated working heart methods.