JoVE Logo

Sign In

Fraunhofer IWS

1 ARTICLES PUBLISHED IN JoVE

image

JoVE Journal

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
Eva-Maria Materne *1, Ilka Maschmeyer *1,2, Alexandra K. Lorenz 1, Reyk Horland 1,2, Katharina M. S. Schimek 1, Mathias Busek 3, Frank Sonntag 3, Roland Lauster 1, Uwe Marx 1,2
1Medical Biotechnology, Technische Universität Berlin, 2TissUse GmbH, 3Fraunhofer IWS

Here, we present a protocol to coculture primary cells, tissue models and punch biopsies in a microfluidic multi-organ chip for up to 28 days. Human dermal microvascular endothelial cells, liver aggregates and skin biopsies were successfully combined in a common media circulation.

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved