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Max Planck Institute for Polymer Research

1 ARTICLES PUBLISHED IN JoVE

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Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy
Márton Gélleri 1, Hilmar Strickfaden 2
1Institute of Molecular Biology (IMB), 2Max Planck Institute for Polymer Research

The present protocol describes a method measuring absolute DNA densities within adherent cell nuclei using Voronoi tessellation of single-molecule localization microscopy data, known volume, genome size, and cell cycle stage.

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